DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chc and cltcb

DIOPT Version :9

Sequence 1:	NP_001096993.1	Gene:	Chc / 32537	FlyBaseID:	FBgn0000319	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	XP_005157480.1	Gene:	cltcb / 503600	ZFINID:	ZDB-GENE-050227-12	Length:	1685	Species:	Danio rerio

Alignment Length:	1679	Identity:	1333/1679 - (79%)
Similarity:	1502/1679 - (89%)	Gaps:	17/1679 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.|||||||||||.|:|||..:..|||||||||||||:||||.:.||||||||:|...|.|||
Zfish     1 MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMSDPNTPIRRP 65

  Fly    66 ISADSAIMNPASKVIALK-AQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFH 129
            |||||||||||||||||| |.|||||||||||||||||||.|||.|||||||||:||||:.:|:|
Zfish    66 ISADSAIMNPASKVIALKDAAKTLQIFNIEMKSKMKAHTMTEDVSFWKWISLNTIALVTDNAVYH 130

  Fly   130 WSMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAI 194
            |||||||.|.|:|||||||.||||||||.:|.|:||||:||||..:||.||||||||:|||||.|
Zfish   131 WSMEGDSQPIKVFDRHSSLAGCQIINYRTDAKQKWLLLIGISAQQNRVVGAMQLYSVDRKVSQPI 195

  Fly   195 EGHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQND 259
            |||||.||.||::.|.|.:||||||||...||||||||||.||.|||.|.|||||||||||||||
Zfish   196 EGHAAGFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQAFPKKAVDVFFPPEAQND 260

  Fly   260 FPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKGQV 324
            ||||||:|:|:|.::||||||||||||:||.|||||||||.:||||||||||:.|||||||||||
Zfish   261 FPVAMQISSKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATSGIIGVNRKGQV 325

  Fly   325 LSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPK 389
            |||.|:||.|||||..|||||||||||||||||||||:||.||||.||..|.|:|||||||.|||
Zfish   326 LSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNNLFAGGNYSEAAKVAANAPK 390

  Fly   390 AILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLK 454
            .|||||.||:|||.|....|.|: |||||||||||||:||||||||||||||.||:|||.|||||
Zfish   391 GILRTPDTIRRFQSVPAQPGQTS-PLLQYFGILLDQGQLNKFESLELCRPVLQQGRKQLLEKWLK 454

  Fly   455 EEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLL 519
            |:|||||||||||||:.|.|||||:||||||||||||||||||||||||||||||.||||::|||
Zfish   455 EDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLL 519

  Fly   520 RSVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTR 584
            |:|||.:||||..|:.|||.:|||||||.||||:|||::::||||:|||||||:|||.||.||||
Zfish   520 RNVMRISPEQGLQFSQMLVQDEEPLADITQIVDVFMEYNLIQQCTSFLLDALKNNRPTEGPLQTR 584

  Fly   585 LLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNA 649
            |||||||.|||||||||||.|||||||||:|||||||||||||||||||||||||||||||:||.
Zfish   585 LLEMNLMHAPQVADAILGNQMFTHYDRAHVAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHLLNP 649

  Fly   650 EWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFY 714
            ||||:|||:||||||:|||:|||:||:|||||||||:|:||||||:.::|.:|||.|||::||||
Zfish   650 EWLVNFFGSLSVEDSMECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLTELFESFKSFEGLFY 714

  Fly   715 FLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVC 779
            ||.||||||||||||||||||||||.|||||||||||||||:|||||||||||||||||||||||
Zfish   715 FLGSIVNFSQDPEVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVC 779

  Fly   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQFSTD 844
            |||||||||||||||||||||||||||||||||||||:|||||||||||:||||||||:||||||
Zfish   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTD 844

  Fly   845 ELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRVVGRY 909
            |||.||||||||||||||||:|:||||.|||||||||||||||||||||:|:||.||||||||:|
Zfish   845 ELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKY 909

  Fly   910 CEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQLIDQ 974
            ||||||||||||||||.||:|||.||||||||||.:||||.|:|.||||.||.|.|||:|.||||
Zfish   910 CEKRDPHLACVAYERGQCDQELIHVCNENSLFKSLSRYLVRRKDPELWASVLLEVNPYRRPLIDQ 974

  Fly   975 VVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIKADRT 1039
            ||||||||||||:::|||||||||||||||||||||||:||:||||:||||||||||||||||||
Zfish   975 VVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRT 1039

  Fly  1040 RVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCN 1104
            |||:|||||:||||||||||||||:|:|||||||:||||||||:||||:.:.||:||.|||||||
Zfish  1040 RVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCN 1104

  Fly  1105 EPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESY 1169
            ||||||||||||||:|||||||||||||||||||::|...|::..:|:|||::||||||||||||
Zfish  1105 EPAVWSQLAKAQLQKGLVKEAIDSYIKADDPSAYMEVGQAAAQSGNWEDLVKFLQMARKKARESY 1169

  Fly  1170 IESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVY 1234
            :|:|||:|.|:|.|||:|||||:|||:|.||::|:||:.:.||:||||||||||||.|||.|||:
Zfish  1170 VETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYEAAKLLYNNVSNFGRLASTLVH 1234

  Fly  1235 LKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDE 1299
            |.|:|.|||.|||||||||||||||||||.:||||||||||||||||||||:||||||:||||:|
Zfish  1235 LGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEE 1299

  Fly  1300 LIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELVF 1364
            ||.:||:||||||||||||||||||||||||.|||||||||||||||||||||||.||||.||||
Zfish  1300 LITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWGELVF 1364

  Fly  1365 LYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLVLAP 1429
            |||||||||||::.||.||.:||:|..||||||||||:||||:|::|||:||||||||:|:||:|
Zfish  1365 LYDKYEEYDNAIITMMNHPADAWKESQFKDIITKVANVELYYRAVQFYLEFKPLLLNDLLIVLSP 1429

  Fly  1430 RMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNI 1494
            |:||||||::|||...||||||||||||:.|||::|||||.|.|.|||:|.||.|||.:||||||
Zfish  1430 RLDHTRAVNFFSKVKQLPLVKPYLRSVQNHNNKSVNEALNNLFITEEDFQALRTSIDAYDNFDNI 1494

  Fly  1495 ALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFL 1559
            :|||.||||||.|||||||||:|||||||||||||||||||||||:||:||...::|||||.|||
Zfish  1495 SLAQSLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDKLYKDAMQYASESKDTELAEELLQWFL 1559

  Fly  1560 ERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTT-------KVDKLELN 1617
            |.|..:||||||:.|||||||||:||.||:|.::||:|||.|||:|||.:       |||||:.:
Zfish  1560 EDDKKECFAACLFTCYDLLRPDVVLETAWRHNLMDFSMPYFIQVMREYLSKVDAIKEKVDKLDAS 1624

  Fly  1618 EAQREKEDDSTEHKNIIQMEPQLMITAGPAMGIPPQ--YAQNYPPGAATVTAAG 1669
            |:.|::|:..||.:.|:...||||:||||.:.:|||  |...||      ||.|
Zfish  1625 ESLRKEEEQLTEAQPIVYGTPQLMLTAGPNVAVPPQQPYGYGYP------TATG 1672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_001096993.1	Clathrin_propel	19..56	CDD:279702	27/36 (75%)
		Clathrin_propel	148..187	CDD:279702	28/38 (74%)
		Clathrin_propel	198..234	CDD:279702	24/35 (69%)
		Clathrin_propel	256..288	CDD:279702	25/31 (81%)
		Clathrin_propel	296..330	CDD:279702	28/33 (85%)
		Clathrin-link	331..353	CDD:286367	18/21 (86%)
		Clathrin_H_link	364..422	CDD:290550	39/57 (68%)
		CLH	542..672	CDD:128594	110/129 (85%)
		Clathrin	546..679	CDD:279031	111/132 (84%)
		CLH	687..825	CDD:128594	123/137 (90%)
		Clathrin	697..827	CDD:279031	118/129 (91%)
		CLH	834..969	CDD:128594	114/134 (85%)
		Clathrin	844..971	CDD:279031	106/126 (84%)
		CLH	980..1118	CDD:128594	119/137 (87%)
		Clathrin	984..1120	CDD:279031	117/135 (87%)
		CLH	1129..1266	CDD:128594	97/136 (71%)
		Clathrin	1134..1268	CDD:279031	93/133 (70%)
		CLH	1275..1417	CDD:128594	118/141 (84%)
		Clathrin	1279..1417	CDD:279031	114/137 (83%)
		CLH	1428..1579	CDD:128594	113/150 (75%)
		Clathrin	1429..1562	CDD:279031	102/132 (77%)
cltcb	XP_005157480.1	Clathrin_propel	19..55	CDD:279702	26/35 (74%)
		Clathrin_propel	149..188	CDD:279702	28/38 (74%)
		Clathrin_propel	199..235	CDD:279702	24/35 (69%)
		Clathrin_propel	257..289	CDD:279702	25/31 (81%)
		Clathrin_propel	297..331	CDD:279702	28/33 (85%)
		Clathrin-link	332..354	CDD:286367	18/21 (86%)
		Clathrin_H_link	365..422	CDD:290550	39/57 (68%)
		CLH	542..675	CDD:128594	112/132 (85%)
		Clathrin	546..679	CDD:279031	111/132 (84%)
		CLH	687..825	CDD:128594	123/137 (90%)
		Clathrin	697..827	CDD:279031	118/129 (91%)
		CLH	834..969	CDD:128594	114/134 (85%)
		Clathrin	844..961	CDD:279031	99/116 (85%)
		CLH	980..1119	CDD:128594	120/138 (87%)
		Clathrin	984..1120	CDD:279031	117/135 (87%)
		TPR repeat	1105..1132	CDD:276809	25/26 (96%)
		CLH	1129..1266	CDD:128594	97/136 (71%)
		Clathrin	1134..1268	CDD:279031	93/133 (70%)
		TPR repeat	1135..1163	CDD:276809	14/27 (52%)
		CLH	1275..1417	CDD:128594	118/141 (84%)
		Clathrin	1279..1417	CDD:279031	114/137 (83%)
		CLH	1428..1579	CDD:128594	113/150 (75%)
		Clathrin	1428..1565	CDD:279031	103/136 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595802
Domainoid	1	1.000	264	1.000	Domainoid score	I1869
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3572
Inparanoid	1	1.050	2601	1.000	Inparanoid score	I26
OMA	1	1.010	-	-		QHG53703
OrthoDB	1	1.010	-	-		D17940at2759
OrthoFinder	1	1.000	-	-		FOG0002324
OrthoInspector	1	1.000	-	-		otm26476
orthoMCL	1	0.900	-	-		OOG6_101144
Panther	1	1.100	-	-	LDO	PTHR10292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R209
SonicParanoid	1	1.000	-	-		X1532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940