DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chc and cltc

DIOPT Version :9

Sequence 1:	NP_001096993.1	Gene:	Chc / 32537	FlyBaseID:	FBgn0000319	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	XP_012812293.1	Gene:	cltc / 496448	XenbaseID:	XB-GENE-984047	Length:	1676	Species:	Xenopus tropicalis

Alignment Length:	1678	Identity:	1344/1678 - (80%)
Similarity:	1511/1678 - (90%)	Gaps:	5/1678 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.|||||||||||.|:|||..:..|||||||||||||:||||.:.|||||||||||.||.|||
Frog     1 MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDANNPIRRP 65

  Fly    66 ISADSAIMNPASKVIALK-AQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFH 129
            ||||:||||||||||||| |.|||||||||||||||||||.:||.|||||||||:||||:.:|:|
Frog    66 ISADNAIMNPASKVIALKDAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYH 130

  Fly   130 WSMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAI 194
            |||||:|.|.|:|||||||.||||||||.:|.|:||||.||||..:||.||||||||:|||||.|
Frog   131 WSMEGESQPVKVFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPI 195

  Fly   195 EGHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQND 259
            ||||||||.||::.|.|.:||||||||...||||||||||.||.|||||.|||||||||||||||
Frog   196 EGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQND 260

  Fly   260 FPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKGQV 324
            ||||||:|.|:|.::||||||||||||:||.|||||||||.:||||||||||:.|||||||||||
Frog   261 FPVAMQISDKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQV 325

  Fly   325 LSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPK 389
            |||.|:||.|||||..|||||||||||||||||||||:||.||||.||..|.|:|||||||.|||
Frog   326 LSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPK 390

  Fly   390 AILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLK 454
            .|||||:||:|||.|....|.|: |||||||||||||:||||||||||||||.||:|||.|||||
Frog   391 GILRTPETIRRFQSVPAQPGQTS-PLLQYFGILLDQGQLNKFESLELCRPVLQQGRKQLLEKWLK 454

  Fly   455 EEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLL 519
            |:|||||||||||||:.|.|||||:|||||||||||||||||||.||||||||||.||||::|||
Frog   455 EDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLL 519

  Fly   520 RSVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTR 584
            |:|||.||:||..||.|||.:|||||||.||||:|||::::||||||||||||:|||.||.||||
Frog   520 RNVMRINPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPTEGPLQTR 584

  Fly   585 LLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNA 649
            |||||||.|||||||||||.||||||||||||||||||||||||||:||||||||||||||:||.
Frog   585 LLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNP 649

  Fly   650 EWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFY 714
            ||||::||:||||||||||:|||:||:|||||||||:|:||||||:..:||:|||.|||::||||
Frog   650 EWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTLSLIELFESFKSFEGLFY 714

  Fly   715 FLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVC 779
            ||.|||||||||:||||||||||||.|||||||||||||||:|||||||||||||||||||||||
Frog   715 FLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVC 779

  Fly   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQFSTD 844
            |||||||||||||||||||||||||||||||||||||:|||||||||||:||||||||:||||||
Frog   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTD 844

  Fly   845 ELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRVVGRY 909
            |||.||||||||||||||||||:||||.|||||||||||||||||||||:|:||.||||||||:|
Frog   845 ELVAEVEKRNRLKLLLPWLESRIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKY 909

  Fly   910 CEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQLIDQ 974
            ||||||||||||||||.||.|||.||||||||||.:||||.|:|.||||.||.|||||:|.||||
Frog   910 CEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWASVLLESNPYRRPLIDQ 974

  Fly   975 VVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIKADRT 1039
            ||||||||||||:::|||||||||||||||||||||||:||:||||:||||||||||||||||||
Frog   975 VVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRT 1039

  Fly  1040 RVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCN 1104
            |||:|||||:||||||||||||||:|:|||||||:||||||||:||||:.:.||:||.|||||||
Frog  1040 RVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCN 1104

  Fly  1105 EPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESY 1169
            ||||||||||||||:|:|||||||||||||||:|::||..|:...:|::||:|||||||||||||
Frog  1105 EPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANASGNWEELVKYLQMARKKARESY 1169

  Fly  1170 IESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVY 1234
            :|:|||:|.|:|.|||:|||||:|||:|.||::|:||:.:.|||||||||||||||.|||.|||:
Frog  1170 VETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVH 1234

  Fly  1235 LKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDE 1299
            |.|:|.|||.|||||||||||||||||||.:||||||||||||||||||||:||||||:||||:|
Frog  1235 LGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEE 1299

  Fly  1300 LIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELVF 1364
            ||.:||:||||||||||||||||||||||||.|||||||||||||||||||||||.||||:||||
Frog  1300 LITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVF 1364

  Fly  1365 LYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLVLAP 1429
            |||||||||||::.||.|.|:||:||.||||||||||:||||:||:|||:||||||||:|:||:|
Frog  1365 LYDKYEEYDNAIITMMNHATDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSP 1429

  Fly  1430 RMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNI 1494
            |:||||||:||||...||||||||||||:.|||::|||||.|.|.|||||.||.|||.:||||||
Frog  1430 RLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNEALNNLFITEEDYQALRTSIDAYDNFDNI 1494

  Fly  1495 ALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFL 1559
            :|||:||||||.|||||||||:||||||||||||||||:||||||:||:||...::|||||.|||
Frog  1495 SLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDRLYKDAMQYASESKDTELAEELLQWFL 1559

  Fly  1560 ERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLELNEAQREKE 1624
            ..|..:||||||:.|||||||||:||.||:|.|:||||||.|||:|||.||||||:.:|:.|::|
Frog  1560 VEDKKECFAACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMREYLTKVDKLDASESLRKEE 1624

  Fly  1625 DDSTEHKNIIQMEPQLMITAGPAMGIPPQYAQNYPPGAATVTAAGGRNMGYPY 1677
            :.:||.:.|:..:||||:||||::.:|||.|..|   ..|..|.|....|:.|
Frog  1625 EQATETQPIVYGQPQLMLTAGPSVPVPPQAAYGY---GYTAPAYGQPQPGFGY 1674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_001096993.1	Clathrin_propel	19..56	CDD:279702	27/36 (75%)
		Clathrin_propel	148..187	CDD:279702	28/38 (74%)
		Clathrin_propel	198..234	CDD:279702	25/35 (71%)
		Clathrin_propel	256..288	CDD:279702	25/31 (81%)
		Clathrin_propel	296..330	CDD:279702	28/33 (85%)
		Clathrin-link	331..353	CDD:286367	18/21 (86%)
		Clathrin_H_link	364..422	CDD:290550	39/57 (68%)
		CLH	542..672	CDD:128594	111/129 (86%)
		Clathrin	546..679	CDD:279031	112/132 (85%)
		CLH	687..825	CDD:128594	123/137 (90%)
		Clathrin	697..827	CDD:279031	118/129 (91%)
		CLH	834..969	CDD:128594	116/134 (87%)
		Clathrin	844..971	CDD:279031	108/126 (86%)
		CLH	980..1118	CDD:128594	119/137 (87%)
		Clathrin	984..1120	CDD:279031	117/135 (87%)
		CLH	1129..1266	CDD:128594	98/136 (72%)
		Clathrin	1134..1268	CDD:279031	94/133 (71%)
		CLH	1275..1417	CDD:128594	120/141 (85%)
		Clathrin	1279..1417	CDD:279031	116/137 (85%)
		CLH	1428..1579	CDD:128594	113/150 (75%)
		Clathrin	1429..1562	CDD:279031	102/132 (77%)
cltc	XP_012812293.1	Clathrin_propel	19..56	CDD:279702	27/36 (75%)
		Clathrin_propel	149..188	CDD:279702	28/38 (74%)
		Clathrin_propel	199..235	CDD:279702	25/35 (71%)
		Clathrin_propel	257..289	CDD:279702	25/31 (81%)
		Clathrin_propel	297..331	CDD:279702	28/33 (85%)
		Clathrin-link	332..355	CDD:370397	19/22 (86%)
		Clathrin_H_link	357..422	CDD:372748	46/65 (71%)
		CLH	542..675	CDD:128594	113/132 (86%)
		CLH	687..825	CDD:128594	123/137 (90%)
		CLH	834..969	CDD:128594	116/134 (87%)
		CLH	980..1119	CDD:128594	120/138 (87%)
		TPR repeat	1106..1132	CDD:276809	23/25 (92%)
		CLH	1129..1266	CDD:128594	98/136 (72%)
		CLH	1275..1417	CDD:128594	120/141 (85%)
		Clathrin	1428..1562	CDD:366214	102/133 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1934
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3572
Inparanoid	1	1.050	2596	1.000	Inparanoid score	I29
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17940at2759
OrthoFinder	1	1.000	-	-		FOG0002324
OrthoInspector	1	1.000	-	-		otm47707
Panther	1	1.100	-	-	LDO	PTHR10292
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1532
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160