DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chc and cltca

DIOPT Version :9

Sequence 1:	NP_001096993.1	Gene:	Chc / 32537	FlyBaseID:	FBgn0000319	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	XP_009303632.1	Gene:	cltca / 323579	ZFINID:	ZDB-GENE-030131-2299	Length:	1685	Species:	Danio rerio

Alignment Length:	1686	Identity:	1335/1686 - (79%)
Similarity:	1508/1686 - (89%)	Gaps:	14/1686 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.|||||||||||.|:|||..:..||||||||||||||||||.:.||||||||.|...|.|||
Zfish     1 MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICVREKVGEQAQVVIIDMADPNTPIRRP 65

  Fly    66 ISADSAIMNPASKVIALK-AQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFH 129
            |||||||||||||||||| |.|||||||||||||||||||.:||.|||||||||:||||:.:|:|
Zfish    66 ISADSAIMNPASKVIALKDAAKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYH 130

  Fly   130 WSMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAI 194
            |||||||.|.|:|||||||.||||||||.:|.|:||||:||||..:||.||||||||:|||||.|
Zfish   131 WSMEGDSQPVKVFDRHSSLAGCQIINYRTDAKQKWLLLIGISAQQNRVVGAMQLYSVDRKVSQPI 195

  Fly   195 EGHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQND 259
            |||||.|..||::.|.|.:||||||||...||||||||||.||.|||.|.|||||||||||||||
Zfish   196 EGHAAGFGQFKMEGNTEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQQFPKKAVDVFFPPEAQND 260

  Fly   260 FPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKGQV 324
            ||||||:|:|:|.:|||||||||||||:||.|||||||||.:||||||||:|:.|||||||||||
Zfish   261 FPVAMQISSKHDVVYLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHDATAGIIGVNRKGQV 325

  Fly   325 LSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPK 389
            |||.|:||.||.||..|||||||||||||||||||||:||.||||.||..|.:||||||||.|||
Zfish   326 LSVCVEEENIIQYITNVLQNPDLALRMAVRNNLAGAEELFGRKFNNLFAGGNFAEAAKVAANAPK 390

  Fly   390 AILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLK 454
            .|||||.||:|||.|....|.|: |||||||||||||:||||||||||||||.||:|||.|||||
Zfish   391 GILRTPDTIRRFQSVPAQPGQTS-PLLQYFGILLDQGQLNKFESLELCRPVLQQGRKQLLEKWLK 454

  Fly   455 EEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLL 519
            |:|||||||||||||:.|.|||||:||||||||||||||||||||.|||||||||.||||::|||
Zfish   455 EDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQFPKIVLYAKKVGYTPDWIFLL 519

  Fly   520 RSVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTR 584
            |:|||.:|:||..||.|||.:|||||||.||||:|||:::|||||:|||||||:|||:||.||||
Zfish   520 RNVMRISPDQGLQFAQMLVQDEEPLADITQIVDVFMEYNLVQQCTSFLLDALKNNRPSEGPLQTR 584

  Fly   585 LLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNA 649
            |||||||.|||||||||||.|||:|||||||||||||||||||||||||||||||||||||:||.
Zfish   585 LLEMNLMHAPQVADAILGNQMFTNYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHLLNP 649

  Fly   650 EWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFY 714
            ||||::||:||||||||||:|||:||:|||||||||:|:||||||:.::|.:|||.|||::||||
Zfish   650 EWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLTELFESFKSFEGLFY 714

  Fly   715 FLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLK----EAKLTDQLPL 775
            ||.||||||||||||||||||||||.|||||||||||||||||||||||||    ||||||||||
Zfish   715 FLGSIVNFSQDPEVHFKYIQAACKTGQIKEVERICRESNCYNPERVKNFLKDLNQEAKLTDQLPL 779

  Fly   776 IIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQ 840
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||:||||||||:||
Zfish   780 IIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQ 844

  Fly   841 FSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRV 905
            |||||||.||||||||||||||||||:||||.|||||||||||||||||||||:|:||.||||||
Zfish   845 FSTDELVAEVEKRNRLKLLLPWLESRIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRV 909

  Fly   906 VGRYCEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQ 970
            ||:|||||||||||||||||.||:|||.||||||||||.:||||.|||.||||.||.|:||::|.
Zfish   910 VGKYCEKRDPHLACVAYERGTCDQELINVCNENSLFKSLSRYLVRRRDPELWASVLLETNPFRRP 974

  Fly   971 LIDQVVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIK 1035
            ||||||||||||||||:::|||||||||||||||||||||||:||:||||:||||||||||||||
Zfish   975 LIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIK 1039

  Fly  1036 ADRTRVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFA 1100
            |||||||:|||||:|||||||||||||::|:||||||||||||||||:||||:.:.||:||.|||
Zfish  1040 ADRTRVMEYINRLDNYDAPDIANIAISSELFEEAFAIFKKFDVNTSAVQVLIEHIGNLDRAYEFA 1104

  Fly  1101 ERCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKA 1165
            ||||||||||||||||||:|||||:|||||||||||||::||..|.:..:|:|||::||||||||
Zfish  1105 ERCNEPAVWSQLAKAQLQKGLVKESIDSYIKADDPSAYMEVVQAADQSGNWEDLVKFLQMARKKA 1169

  Fly  1166 RESYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAI 1230
            ||||:|:|||:|.|:|.|||:|||||:|||:|.||::|:||:.:.||:||||||||||||.|||.
Zfish  1170 RESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYEAAKLLYNNVSNFGRLAS 1234

  Fly  1231 TLVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRG 1295
            |||:|.|:|.|||.|||||||||||||||||||.:||||||||||||||||||||:||||||:||
Zfish  1235 TLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRG 1299

  Fly  1296 YFDELIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWS 1360
            ||:|||.:||:||||||||||||||||||||||||.|||||||||||||||||||||||.||||:
Zfish  1300 YFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWA 1364

  Fly  1361 ELVFLYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLL 1425
            |||||||||||:|||::.||:|||:||:||.||||||||||:|||||||:|||:|:||||||:|:
Zfish  1365 ELVFLYDKYEEFDNAIITMMSHPTDAWKEGQFKDIITKVANVELYYKAIQFYLEFRPLLLNDLLI 1429

  Fly  1426 VLAPRMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDN 1490
            ||:||:||:|||::|||...||||||||||||:.|||::|||||.|.|.|||||.||.|||.:||
Zfish  1430 VLSPRLDHSRAVNFFSKVKQLPLVKPYLRSVQNHNNKSVNEALNNLFISEEDYQALRTSIDAYDN 1494

  Fly  1491 FDNIALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELL 1555
            ||||:|||:||||||.|||||||||:|||||||||||||||||||||||:||:||...::|||||
Zfish  1495 FDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDKLYKDAMQYASESKDTELAEELL 1559

  Fly  1556 GWFLERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLELNEAQ 1620
            .|||:.:..:||||||:.|||||||||:||.:|::.|:||||||.|||:|||.:||||||.:|:.
Zfish  1560 QWFLDENKKECFAACLFTCYDLLRPDVVLETSWRNNIMDFAMPYFIQVMREYLSKVDKLETSESL 1624

  Fly  1621 REKEDDSTEHKNIIQMEPQLMITAGPAMGIPPQY--------AQNYPPGAATVTAAGGRNM 1673
            |::|:.:||.:.|:...||||:||||::.:|||.        |..|||.|.......|..|
Zfish  1625 RKEEEQATETQPIVYGTPQLMLTAGPSVPVPPQQGYGYGYTAAPGYPPQAPQAQPGFGYGM 1685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_001096993.1	Clathrin_propel	19..56	CDD:279702	28/36 (78%)
		Clathrin_propel	148..187	CDD:279702	28/38 (74%)
		Clathrin_propel	198..234	CDD:279702	23/35 (66%)
		Clathrin_propel	256..288	CDD:279702	26/31 (84%)
		Clathrin_propel	296..330	CDD:279702	27/33 (82%)
		Clathrin-link	331..353	CDD:286367	17/21 (81%)
		Clathrin_H_link	364..422	CDD:290550	39/57 (68%)
		CLH	542..672	CDD:128594	111/129 (86%)
		Clathrin	546..679	CDD:279031	112/132 (85%)
		CLH	687..825	CDD:128594	124/141 (88%)
		Clathrin	697..827	CDD:279031	119/133 (89%)
		CLH	834..969	CDD:128594	115/134 (86%)
		Clathrin	844..971	CDD:279031	107/126 (85%)
		CLH	980..1118	CDD:128594	119/137 (87%)
		Clathrin	984..1120	CDD:279031	117/135 (87%)
		CLH	1129..1266	CDD:128594	98/136 (72%)
		Clathrin	1134..1268	CDD:279031	94/133 (71%)
		CLH	1275..1417	CDD:128594	121/141 (86%)
		Clathrin	1279..1417	CDD:279031	117/137 (85%)
		CLH	1428..1579	CDD:128594	111/150 (74%)
		Clathrin	1429..1562	CDD:279031	101/132 (77%)
cltca	XP_009303632.1	Clathrin_propel	19..55	CDD:279702	27/35 (77%)
		Clathrin_propel	149..188	CDD:279702	28/38 (74%)
		Clathrin_propel	199..235	CDD:279702	23/35 (66%)
		Clathrin_propel	257..289	CDD:279702	26/31 (84%)
		Clathrin_propel	297..331	CDD:279702	27/33 (82%)
		Clathrin-link	332..354	CDD:286367	17/21 (81%)
		Clathrin_H_link	365..422	CDD:290550	39/57 (68%)
		CLH	542..675	CDD:128594	113/132 (86%)
		Clathrin	546..679	CDD:279031	112/132 (85%)
		CLH	687..829	CDD:128594	124/141 (88%)
		Clathrin	697..831	CDD:279031	119/133 (89%)
		CLH	838..973	CDD:128594	115/134 (86%)
		Clathrin	848..965	CDD:279031	101/116 (87%)
		CLH	984..1123	CDD:128594	120/138 (87%)
		Clathrin	988..1124	CDD:279031	117/135 (87%)
		CLH	1133..1270	CDD:128594	98/136 (72%)
		Clathrin	1138..1272	CDD:279031	94/133 (71%)
		CLH	1279..1421	CDD:128594	121/141 (86%)
		Clathrin	1283..1421	CDD:279031	117/137 (85%)
		CLH	1432..1583	CDD:128594	111/150 (74%)
		Clathrin	1432..1569	CDD:279031	101/136 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595801
Domainoid	1	1.000	264	1.000	Domainoid score	I1869
eggNOG	1	0.900	-	-		E1_KOG0985
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3572
Inparanoid	1	1.050	2601	1.000	Inparanoid score	I26
OMA	1	1.010	-	-		QHG53703
OrthoDB	1	1.010	-	-		D17940at2759
OrthoFinder	1	1.000	-	-		FOG0002324
OrthoInspector	1	1.000	-	-		otm26476
orthoMCL	1	0.900	-	-		OOG6_101144
Panther	1	1.100	-	-	O	PTHR10292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R209
SonicParanoid	1	1.000	-	-		X1532
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800