DRSC/TRiP Functional Genomics Resources

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Protein Alignment Chc and Clhc1

DIOPT Version :9

Sequence 1:NP_001096993.1 Gene:Chc / 32537 FlyBaseID:FBgn0000319 Length:1678 Species:Drosophila melanogaster
Sequence 2:XP_017454630.1 Gene:Clhc1 / 289865 RGDID:1307937 Length:595 Species:Rattus norvegicus


Alignment Length:489 Identity:106/489 - (21%)
Similarity:194/489 - (39%) Gaps:131/489 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 LVTETSVFHWSMEGD-----SMPQKMFDRHSSLNG--CQIINYRCNASQQWLLLVGISALPSRVA 178
            ::|||.....:.||.     ::.:.:||:.|:.:.  .|:|:|             ::|..|   
  Rat    31 IITETKRVGCNEEGPPDEYYTIYRNVFDKCSTTDRKIFQVIDY-------------VNAYKS--- 79

  Fly   179 GAMQLYSVERKVSQAIE----GHAASF---ATFKIDANKEPTTLFCFAVRT-ATGGKLHIIEVGA 235
               .|.|::::....||    |...:|   ...|:.| .|||.|.....|| ....|:.||:..:
  Rat    80 ---VLTSIKKEYDAFIETVKKGRRNAFYLHGKLKVLA-AEPTALVYHQRRTIQLEAKMRIIDNNS 140

  Fly   236 PPNGNQPFAKKAVDVFFPPEAQ-----NDFPVAMQVSAK-----------YDTIYLITKYGYIHL 284
                      ||:.:......|     .:..|.:..|:|           .|::.|.....  |.
  Rat   141 ----------KAIQLQIDQMKQLRMEYENTEVKLCASSKQLWKPIPGMTLQDSVNLDALNN--HK 193

  Fly   285 YDMETATCIYMNRISAD--TIFVTAPHEA---SGGIIGVNRKG----------------QVLSVT 328
            .::|. .|   .::..|  |::|:|..:|   ...|:.:.|:.                ||:|.|
  Rat   194 QNLED-KC---RKLKQDMSTMYVSAQKKADLDEEMIVLLKRRDIAENLNKDLRFRHQRLQVISHT 254

  Fly   329 VD----EEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLF----------------VRKFNKLFT 373
            ::    :...||: ..||:.  :....|:..:....::||                :.:|::|.:
  Rat   255 LNSWMKQNMRIPF-KDVLER--IQQTKAIYGHAKVVDELFEDDPNKTKEAIVMLYYIERFHELIS 316

  Fly   374 AGQYAEAAKVAALAPKAILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGK-----LNKFES 433
            .|:|.:||..||.:||.||:...|:.:|:.:....|... |||.:|..:.:..:     :|...:
  Rat   317 LGEYEKAACFAANSPKRILQNAGTMNKFKAIGKVRGKPL-PLLLFFEAIFNTSQAFKRAINVDLT 380

  Fly   434 LELCRPVLLQGKKQLCEKWLKEEKLECSEELGDLV----------KASDLTLALSIYLRANVPNK 488
            ||..:..|.:.:..|...|:.:.||..||::||.:          |:..|.||..:|....:..|
  Rat   381 LEGIKCGLSEERLDLVTHWVTQAKLTFSEKVGDAICAYGEQHPYHKSKCLALAQIVYNECGLHKK 445

  Fly   489 VIQCFAETGQFQKI---VLYAKKVNYTPDYVFLL 519
            .|.|....|||.:.   :..:|.:| |.|.:.|:
  Rat   446 AILCLCRQGQFHEAMEHIQQSKDIN-TDDLIQLI 478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ChcNP_001096993.1 Clathrin_propel 19..56 CDD:279702
Clathrin_propel 148..187 CDD:279702 7/40 (18%)
Clathrin_propel 198..234 CDD:279702 12/39 (31%)
Clathrin_propel 256..288 CDD:279702 7/47 (15%)
Clathrin_propel 296..330 CDD:279702 11/54 (20%)
Clathrin-link 331..353 CDD:286367 4/21 (19%)
Clathrin_H_link 364..422 CDD:290550 20/73 (27%)
CLH 542..672 CDD:128594
Clathrin 546..679 CDD:279031
CLH 687..825 CDD:128594
Clathrin 697..827 CDD:279031
CLH 834..969 CDD:128594
Clathrin 844..971 CDD:279031
CLH 980..1118 CDD:128594
Clathrin 984..1120 CDD:279031
CLH 1129..1266 CDD:128594
Clathrin 1134..1268 CDD:279031
CLH 1275..1417 CDD:128594
Clathrin 1279..1417 CDD:279031
CLH 1428..1579 CDD:128594
Clathrin 1429..1562 CDD:279031
Clhc1XP_017454630.1 TSNAXIP1_N 30..144 CDD:406226 32/142 (23%)
Clathrin_H_link 307..361 CDD:404683 18/54 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166353654
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0985
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.830

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