DRSC/TRiP Functional Genomics Resources

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Protein Alignment Chc and CLHC1

DIOPT Version :9

Sequence 1:NP_001096993.1 Gene:Chc / 32537 FlyBaseID:FBgn0000319 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_689598.2 Gene:CLHC1 / 130162 HGNCID:26453 Length:586 Species:Homo sapiens


Alignment Length:610 Identity:115/610 - (18%)
Similarity:210/610 - (34%) Gaps:198/610 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 LVTETSVFHWSMEGDS-----MPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGA 180
            ::|||.....|.||.:     :.:.:||:        :|.:             |:|..|.:...
Human    31 IITETERLGCSEEGPADEYYIIYRNVFDK--------VIEH-------------ITAYKSILTSI 74

  Fly   181 MQLYSV-------ERKVSQAIEGHAASFATFKIDANKEPTTLFCFAVRT-ATGGKLHIIEVGAPP 237
            .:.|..       :|:.:..:.|.....|.       |||.|..:..|| ....|:.|||..:  
Human    75 KKEYDAFIETIKKDRRTTFCLHGKLKGLAA-------EPTALVYYRKRTIQLEAKMRIIESNS-- 130

  Fly   238 NGNQPFAKKAVDVFFPPEAQNDFPVAMQVSAKYDT--------------------------IYLI 276
                            .:.|:......|..|:|||                          :..:
Human   131 ----------------SKIQSQIDHIKQCRAEYDTKEVKYCTFSKDPSKPIPGMTLQESMNLDAL 179

  Fly   277 TKYGYIHLYD--METATCIYMNRISA--------DTIFVTAPHEASGGIIGVNRK---------- 321
            ||| ..||.|  .|....:.:..:.|        :.|.:....:.:..:   |:|          
Human   180 TKY-MKHLEDKYAEIKQAMLIKYVPAQRKADLDEEMIVLLKRRDVAENL---NKKLQFCHQRLQI 240

  Fly   322 -GQVLSVTVDEEQIIPYINTV--------LQNPDLALRMAVRNNLAGAEDL-----FVRKFNKLF 372
             .|.||..|..:...|:.:.|        ||.....:...:.::...|::.     ::.:||:|.
Human   241 ISQALSSWVKSDMSSPFQDFVEQIQKTKYLQGDQGIVEELMEDDPRRAKEAEIMLHYIERFNELI 305

  Fly   373 TAGQYAEAAKVAALAPKAILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQG----KLNKFES 433
            :.|:|.:||..||.:|:.|||...|:..|:.|....|...|.||.:..:.:...    .::...:
Human   306 SLGEYEKAACYAANSPRRILRNIGTMNTFKAVGKIRGKPLPLLLFFEALFITSHAFPCPVDAALT 370

  Fly   434 LELCRPVLLQGKKQLCEKWLKEEKLECSEELGDLV----------KASDLTLALSIYLRANVPNK 488
            ||..:..|.:.:..|...|:.:|:|..|||.||::          ||..|.||..:|....:..|
Human   371 LEGIKCGLSEKRLDLVTNWVTQERLTFSEEAGDVICDYGEQDTYNKAKCLALAQIVYSECGLHKK 435

  Fly   489 VIQCFAETGQFQKIVLYAKKV-NYTPDYVFLLRSVMRSNPEQGAGFASMLVAEEEPLADINQIVD 552
            .|.|..:.||..:::.|.::: ::|.|                                  .::.
Human   436 AILCLCKQGQTHRVMEYIQQLKDFTTD----------------------------------DLLQ 466

  Fly   553 IFMEHSMVQ--QCTAFLLDALKHNRPAEGALQTRLLEMNLMSAP-----------------QVAD 598
            :.|....|:  ||   |...|...:|   :|...|..::|.||.                 ...:
Human   467 LLMSCPQVELIQC---LTKELNEKQP---SLSFGLAILHLFSADMKKVGIKLLQEINKGGIDAVE 525

  Fly   599 AILGNAMFTHYDR-AHIAQLCEKAG 622
            :::.|..|...:: ..:|.:|.:.|
Human   526 SLMINDSFCSIEKWQEVANICSQNG 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ChcNP_001096993.1 Clathrin_propel 19..56 CDD:279702
Clathrin_propel 148..187 CDD:279702 5/45 (11%)
Clathrin_propel 198..234 CDD:279702 11/36 (31%)
Clathrin_propel 256..288 CDD:279702 12/59 (20%)
Clathrin_propel 296..330 CDD:279702 7/52 (13%)
Clathrin-link 331..353 CDD:286367 4/29 (14%)
Clathrin_H_link 364..422 CDD:290550 20/57 (35%)
CLH 542..672 CDD:128594 17/101 (17%)
Clathrin 546..679 CDD:279031 17/97 (18%)
CLH 687..825 CDD:128594
Clathrin 697..827 CDD:279031
CLH 834..969 CDD:128594
Clathrin 844..971 CDD:279031
CLH 980..1118 CDD:128594
Clathrin 984..1120 CDD:279031
CLH 1129..1266 CDD:128594
Clathrin 1134..1268 CDD:279031
CLH 1275..1417 CDD:128594
Clathrin 1279..1417 CDD:279031
CLH 1428..1579 CDD:128594
Clathrin 1429..1562 CDD:279031
CLHC1NP_689598.2 TSNAXIP1_N 30..136 CDD:292367 27/150 (18%)
Clathrin_H_link 297..354 CDD:290550 20/56 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159603
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0985
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.830

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