DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chc and CLTC

DIOPT Version :9

Sequence 1:	NP_001096993.1	Gene:	Chc / 32537	FlyBaseID:	FBgn0000319	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_001275582.1	Gene:	CLTC / 1213	HGNCID:	2092	Length:	1679	Species:	Homo sapiens

Alignment Length:	1668	Identity:	1333/1668 - (79%)
Similarity:	1506/1668 - (90%)	Gaps:	9/1668 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.|||||||||||.|:|||..:..|||||||||||||:||||.:.||||||||||.:||.|||
Human     1 MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRP 65

  Fly    66 ISADSAIMNPASKVIALK----AQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETS 126
            ||||||||||||||||||    :.|||||||||||||||||||.:||.|||||||||:||||:.:
Human    66 ISADSAIMNPASKVIALKGIKESGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNA 130

  Fly   127 VFHWSMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVS 191
            |:||||||:|.|.|||||||||.||||||||.:|.|:||||.||||..:||.||||||||:||||
Human   131 VYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVS 195

  Fly   192 QAIEGHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEA 256
            |.|||||||||.||::.|.|.:||||||||...||||||||||.||.|||||.||||||||||||
Human   196 QPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEA 260

  Fly   257 QNDFPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRK 321
            |||||||||:|.|:|.::||||||||||||:||.|||||||||.:||||||||||:.||||||||
Human   261 QNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRK 325

  Fly   322 GQVLSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAAL 386
            ||||||.|:||.|||||..|||||||||||||||||||||:||.||||.||..|.|:|||||||.
Human   326 GQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAAN 390

  Fly   387 APKAILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEK 451
            |||.|||||.||:|||.|....|.|: |||||||||||||:|||:||||||||||.||:|||.||
Human   391 APKGILRTPDTIRRFQSVPAQPGQTS-PLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK 454

  Fly   452 WLKEEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYV 516
            ||||:|||||||||||||:.|.|||||:|||||||||||||||||||.||||||||||.||||::
Human   455 WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWI 519

  Fly   517 FLLRSVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGAL 581
            ||||:|||.:|:||..||.|||.:|||||||.||||:|||::::||||||||||||:|||:||.|
Human   520 FLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPL 584

  Fly   582 QTRLLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHM 646
            ||||||||||.|||||||||||.||||||||||||||||||||||||||:||||||||||||||:
Human   585 QTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHL 649

  Fly   647 LNAEWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDG 711
            ||.||||::||:||||||||||:|||:||:|||||||||:|:||||||:.::||:|||.|||::|
Human   650 LNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEG 714

  Fly   712 LFYFLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLI 776
            |||||.|||||||||:||||||||||||.|||||||||||||||:||||||||||||||||||||
Human   715 LFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLI 779

  Fly   777 IVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQF 841
            ||||||||||||||||||||||||||||||||||||||||:|||||||||||:||||||||:|||
Human   780 IVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQF 844

  Fly   842 STDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRVV 906
            ||||||.||||||||||||||||:|:||||.|||||||||||||||||||||:|:||.|||||||
Human   845 STDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVV 909

  Fly   907 GRYCEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQL 971
            |:|||||||||||||||||.||.|||.||||||||||.:||||.|:|.|||..||.|||||:|.|
Human   910 GKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPL 974

  Fly   972 IDQVVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIKA 1036
            |||||||||||||||:::|||||||||||||||||||||||:||:||||:|||||||||||||||
Human   975 IDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKA 1039

  Fly  1037 DRTRVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAE 1101
            ||||||:|||||:||||||||||||||:|:|||||||:||||||||:||||:.:.||:||.||||
Human  1040 DRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAE 1104

  Fly  1102 RCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKAR 1166
            |||||||||||||||||:|:|||||||||||||||:|::||..|:...:|::||:||||||||||
Human  1105 RCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKAR 1169

  Fly  1167 ESYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAIT 1231
            |||:|:|||:|.|:|.|||:|||||:|||:|.||::|:||:.:.|||||||||||||||.|||.|
Human  1170 ESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLAST 1234

  Fly  1232 LVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGY 1296
            ||:|.|:|.|||.|||||||||||||||||||.:||||||||||||||||||||:||||||:|||
Human  1235 LVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGY 1299

  Fly  1297 FDELIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSE 1361
            |:|||.:||:||||||||||||||||||||||||.|||||||||||||||||||||||.||||:|
Human  1300 FEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAE 1364

  Fly  1362 LVFLYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLV 1426
            ||||||||||||||::.||.|||:||:||.||||||||||:||||:||:|||:||||||||:|:|
Human  1365 LVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMV 1429

  Fly  1427 LAPRMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNF 1491
            |:||:||||||:||||...||||||||||||:.|||::||:||.|.|.|||||.||.|||.:|||
Human  1430 LSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNF 1494

  Fly  1492 DNIALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLG 1556
            |||:|||:||||||.|||||||||:||||||||||||||||.||||||:||:||...::|||||.
Human  1495 DNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQ 1559

  Fly  1557 WFLERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLELNEAQR 1621
            |||:.:..:||.|||:.|||||||||:||.||:|.|:||||||.|||::||.||||||:.:|:.|
Human  1560 WFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLR 1624

  Fly  1622 EKEDDSTEHKNIIQMEPQLMITAGPAMGIPPQ----YAQNYPP 1660
            ::|:.:||.:.|:..:||||:||||::.:|||    |....||
Human  1625 KEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPP 1667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_001096993.1	Clathrin_propel	19..56	CDD:279702	27/36 (75%)
		Clathrin_propel	148..187	CDD:279702	28/38 (74%)
		Clathrin_propel	198..234	CDD:279702	25/35 (71%)
		Clathrin_propel	256..288	CDD:279702	25/31 (81%)
		Clathrin_propel	296..330	CDD:279702	28/33 (85%)
		Clathrin-link	331..353	CDD:286367	18/21 (86%)
		Clathrin_H_link	364..422	CDD:290550	39/57 (68%)
		CLH	542..672	CDD:128594	111/129 (86%)
		Clathrin	546..679	CDD:279031	112/132 (85%)
		CLH	687..825	CDD:128594	123/137 (90%)
		Clathrin	697..827	CDD:279031	118/129 (91%)
		CLH	834..969	CDD:128594	114/134 (85%)
		Clathrin	844..971	CDD:279031	106/126 (84%)
		CLH	980..1118	CDD:128594	119/137 (87%)
		Clathrin	984..1120	CDD:279031	117/135 (87%)
		CLH	1129..1266	CDD:128594	98/136 (72%)
		Clathrin	1134..1268	CDD:279031	94/133 (71%)
		CLH	1275..1417	CDD:128594	121/141 (86%)
		Clathrin	1279..1417	CDD:279031	117/137 (85%)
		CLH	1428..1579	CDD:128594	110/150 (73%)
		Clathrin	1429..1562	CDD:279031	101/132 (77%)
CLTC	NP_001275582.1	Clathrin_propel	19..56	CDD:279702	27/36 (75%)
		WD40-like repeat 1	24..67		32/42 (76%)
		WD40-like repeat 3	112..153		31/40 (78%)
		Clathrin_propel	152..191	CDD:279702	28/38 (74%)
		WD40-like repeat 4	154..199		33/44 (75%)
		WD40-like repeat 5	200..261		47/60 (78%)
		Clathrin_propel	202..238	CDD:279702	25/35 (71%)
		Clathrin_propel	260..292	CDD:279702	25/31 (81%)
		WD40-like repeat 6	262..305		34/42 (81%)
		Clathrin_propel	300..334	CDD:279702	28/33 (85%)
		WD40-like repeat 7	306..334		24/27 (89%)
		Clathrin-link	335..358	CDD:312688	19/22 (86%)
		Clathrin_H_link	360..425	CDD:316363	46/65 (71%)
		Binding site for the uncoating ATPase, involved in lattice disassembly. /evidence=ECO:0000255	453..469		14/15 (93%)
		Involved in spindle localization and interaction with TACC3. /evidence=ECO:0000269\|PubMed:23918938	461..511		44/49 (90%)
		Flexible linker	484..527		37/42 (88%)
		Heavy chain arm	528..1679		914/1140 (80%)
		Distal segment	528..638		89/109 (82%)
		CLH	545..678	CDD:128594	113/132 (86%)
		Proximal segment	643..1679		819/1025 (80%)
		CLH	690..828	CDD:128594	123/137 (90%)
		CLH	837..972	CDD:128594	114/134 (85%)
		CLH	983..1122	CDD:128594	120/138 (87%)
		TPR repeat	1109..1135	CDD:276809	23/25 (92%)
		CLH	1132..1269	CDD:128594	98/136 (72%)
		Involved in binding clathrin light chain. /evidence=ECO:0000250	1217..1526		255/308 (83%)
		CLH	1278..1420	CDD:128594	121/141 (86%)
		Clathrin	1431..1565	CDD:306985	101/133 (76%)
		Trimerization. /evidence=ECO:0000250	1554..1679		65/114 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159602
Domainoid	1	1.000	267	1.000	Domainoid score	I1886
eggNOG	1	0.900	-	-		E1_KOG0985
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3572
Inparanoid	1	1.050	2706	1.000	Inparanoid score	I26
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53703
OrthoDB	1	1.010	-	-		D17940at2759
OrthoFinder	1	1.000	-	-		FOG0002324
OrthoInspector	1	1.000	-	-		otm40522
orthoMCL	1	0.900	-	-		OOG6_101144
Panther	1	1.100	-	-	LDO	PTHR10292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R209
SonicParanoid	1	1.000	-	-		X1532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800