DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chc and cltcl1

DIOPT Version :9

Sequence 1:	NP_001096993.1	Gene:	Chc / 32537	FlyBaseID:	FBgn0000319	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	XP_004910633.2	Gene:	cltcl1 / 100492311	XenbaseID:	XB-GENE-22064760	Length:	1681	Species:	Xenopus tropicalis

Alignment Length:	1667	Identity:	1315/1667 - (78%)
Similarity:	1493/1667 - (89%)	Gaps:	5/1667 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.||||||||:||.|:|||..:..|||||||||||||:||||.:.||||||||.:..:|.|||
Frog     1 MAQILPIRFQEHMQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMAEPNSPLRRP 65

  Fly    66 ISADSAIMNPASKVIALK-AQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFH 129
            |||:|||||||||||||| |.|||||||||||||||||||:|:|:||||||:||:||||||:|:|
Frog    66 ISAESAIMNPASKVIALKDAGKTLQIFNIEMKSKMKAHTMSEEVIFWKWISVNTVALVTETAVYH 130

  Fly   130 WSMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAI 194
            |||||||.||||||||:||.||||||||.:..|:||||:||||..:||.||||||||:|||||.|
Frog   131 WSMEGDSQPQKMFDRHASLAGCQIINYRTDEQQKWLLLIGISAQQNRVVGAMQLYSVDRKVSQPI 195

  Fly   195 EGHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQND 259
            |||||:||.|||:.|.:|:||||||||...||||||||||.|.||||||||||||||||||||.|
Frog   196 EGHAAAFAEFKIERNSKPSTLFCFAVRGQAGGKLHIIEVGQPANGNQPFAKKAVDVFFPPEAQTD 260

  Fly   260 FPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKGQV 324
            ||||||:.:|:..|||||||||||:||:|:..|||||||||||||||||:|.:.||||||:||||
Frog   261 FPVAMQIGSKHGVIYLITKYGYIHMYDLESGACIYMNRISADTIFVTAPYEPTSGIIGVNKKGQV 325

  Fly   325 LSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPK 389
            |||.|:||.|:.|..:|||||||.||||||:||.|||:||.||||.:|..|.|:|||||||.|||
Frog   326 LSVCVEEENIVNYATSVLQNPDLGLRMAVRSNLPGAEELFARKFNTMFAQGNYSEAAKVAASAPK 390

  Fly   390 AILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLK 454
            .||||.:||::.|.|....|..: |||||||||||||:|||.||||||||||.||:|||.|||||
Frog   391 GILRTAETIRKIQAVPAQPGQAS-PLLQYFGILLDQGQLNKLESLELCRPVLQQGRKQLLEKWLK 454

  Fly   455 EEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLL 519
            |:|||||||||||||..|.|||||:||||||||||||||||||||||||||||||.||||::|||
Frog   455 EDKLECSEELGDLVKTVDPTLALSVYLRANVPNKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLL 519

  Fly   520 RSVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTR 584
            |||||.:|:||..||.|||.:|||||:||||||:|||:|::||||:|||||||:|||:||.||||
Frog   520 RSVMRISPDQGLQFAQMLVQDEEPLANINQIVDVFMENSLIQQCTSFLLDALKNNRPSEGHLQTR 584

  Fly   585 LLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNA 649
            ||||||:.|||||||||||.|||||||||||||||||||||||||||||||||||||||||:|||
Frog   585 LLEMNLIHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHLLNA 649

  Fly   650 EWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFY 714
            ||||:|||:||||||:|||:|||:||:|||||:.||:|:||||||..::|::|||.||||:||||
Frog   650 EWLVNFFGSLSVEDSVECLRAMLSANIRQNLQLSVQVASKYHEQLGTQSLVELFESFKSYEGLFY 714

  Fly   715 FLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVC 779
            ||.|||||||||:||||||||||||.|||||||||||||||||||||||||||||||||||||||
Frog   715 FLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVC 779

  Fly   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQFSTD 844
            |||||||||||||||||||||||||||||||||:|.|||||||||||||:|||||:||.||||||
Frog   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRIPAVVGGLLDVDCSEDVIKNLIMVVHGQFSTD 844

  Fly   845 ELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRVVGRY 909
            |||.||||||||||||||||||:||||.|||||||||||||||||||||:|:||.||||.|||:|
Frog   845 ELVAEVEKRNRLKLLLPWLESRIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSCVVGKY 909

  Fly   910 CEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQLIDQ 974
            ||||||||||||||||.||.|||.||||||||||||||||.|:||||||.||.|:||::||||||
Frog   910 CEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVRRKDAELWANVLEENNPFRRQLIDQ 974

  Fly   975 VVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIKADRT 1039
            ||||||||||||:::||||||||||:||||||||||||:||:||||:||||||||||||||||||
Frog   975 VVQTALSETQDPEEVSVTVKAFMTAELPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRT 1039

  Fly  1040 RVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCN 1104
            |||:|||||:||||||||||||||||:|||||||:|||||||||||||:.:.||:||.|||||||
Frog  1040 RVMEYINRLDNYDAPDIANIAISNQLFEEAFAIFRKFDVNTSAIQVLIEHIGNLDRAYEFAERCN 1104

  Fly  1105 EPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESY 1169
            |.||||||.:||||:.||||||||||||||||:|::||..||:..:|:|||::|||||||||||:
Frog  1105 ESAVWSQLGRAQLQKDLVKEAIDSYIKADDPSSYMEVVQAASRNSNWEDLVKFLQMARKKARESF 1169

  Fly  1170 IESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVY 1234
            :|:|||:|.|:|.||::||||:||||:|.||::|:||:.:||||||||||||||||||||.|||:
Frog  1170 VETELIFALAKTNRLSELEEFVSGPNNAHIQQVGDRCYEEGMYDAAKLLYNNVSNFARLASTLVH 1234

  Fly  1235 LKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDE 1299
            |.|:|.|||||||||||||||||||||||..|||||||||||||:||||||:||:|||:||||:|
Frog  1235 LGEYQAAVDSARKANSTRTWKEVCFACVDGTEFRLAQMCGLHIVIHADELEELISYYQDRGYFEE 1299

  Fly  1300 LIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELVF 1364
            ||||||:||||||||||||||||||||||||.|||||||||||||||||||||||.||||.||||
Frog  1300 LIALLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWGELVF 1364

  Fly  1365 LYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLVLAP 1429
            |||||||||||::.||.|||.||:||.||||:|||||:||||||::||:::||||:||:|:||:|
Frog  1365 LYDKYEEYDNAIITMMNHPTSAWKEGQFKDIVTKVANVELYYKALQFYMEYKPLLINDLLIVLSP 1429

  Fly  1430 RMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNI 1494
            |:||||.|:||.|...||||||||||||:.|||::|||||.||.:||||||||.|||.:||||||
Frog  1430 RLDHTRTVNYFFKVNQLPLVKPYLRSVQNHNNKSVNEALNNLLTEEEDYQGLRASIDAYDNFDNI 1494

  Fly  1495 ALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFL 1559
            :|||:||||||.||||||||||||||||||||||||||:||||||.|||||...::||.||.|||
Frog  1495 SLAQRLEKHELIEFRRIAAYLYKGNNRWKQSVELCKKDRLYKDAMLYAAESKDTELAENLLQWFL 1559

  Fly  1560 ERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLELNEAQREKE 1624
            |....:||||.|:.|||||..|::|||||:|.|:||||||.|||:|||.||||||...|:.|::.
Frog  1560 EEGKQECFAATLFTCYDLLHADIVLELAWRHHIMDFAMPYFIQVMREYLTKVDKLHAAESLRKEA 1624

  Fly  1625 DDSTEHKNIIQMEPQLMITAGPAMGIPPQYAQNYPPGAATVT 1666
            :..||...|: ...|||:||||:..:|||  .|:|.|.|..|
Frog  1625 EQVTEPTPIV-FGQQLMLTAGPSGVVPPQ--PNFPYGYAAPT 1663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_001096993.1	Clathrin_propel	19..56	CDD:279702	27/36 (75%)
		Clathrin_propel	148..187	CDD:279702	27/38 (71%)
		Clathrin_propel	198..234	CDD:279702	25/35 (71%)
		Clathrin_propel	256..288	CDD:279702	23/31 (74%)
		Clathrin_propel	296..330	CDD:279702	27/33 (82%)
		Clathrin-link	331..353	CDD:286367	14/21 (67%)
		Clathrin_H_link	364..422	CDD:290550	34/57 (60%)
		CLH	542..672	CDD:128594	112/129 (87%)
		Clathrin	546..679	CDD:279031	113/132 (86%)
		CLH	687..825	CDD:128594	123/137 (90%)
		Clathrin	697..827	CDD:279031	118/129 (91%)
		CLH	834..969	CDD:128594	115/134 (86%)
		Clathrin	844..971	CDD:279031	108/126 (86%)
		CLH	980..1118	CDD:128594	117/137 (85%)
		Clathrin	984..1120	CDD:279031	115/135 (85%)
		CLH	1129..1266	CDD:128594	100/136 (74%)
		Clathrin	1134..1268	CDD:279031	96/133 (72%)
		CLH	1275..1417	CDD:128594	118/141 (84%)
		Clathrin	1279..1417	CDD:279031	114/137 (83%)
		CLH	1428..1579	CDD:128594	112/150 (75%)
		Clathrin	1429..1562	CDD:279031	103/132 (78%)
cltcl1	XP_004910633.2	Clathrin_propel	19..55	CDD:396117	26/35 (74%)
		Clathrin_propel	149..188	CDD:396117	27/38 (71%)
		Clathrin_propel	199..235	CDD:396117	25/35 (71%)
		Clathrin_propel	257..289	CDD:396117	23/31 (74%)
		Clathrin_propel	297..331	CDD:396117	27/33 (82%)
		Clathrin-link	332..355	CDD:401271	15/22 (68%)
		Clathrin_H_link	357..422	CDD:404683	40/65 (62%)
		CLH	542..675	CDD:128594	114/132 (86%)
		CLH	687..825	CDD:128594	123/137 (90%)
		CLH	834..969	CDD:128594	115/134 (86%)
		Clathrin	980..1120	CDD:395512	119/139 (86%)
		CLH	1129..1263	CDD:128594	98/133 (74%)
		CLH	1275..1417	CDD:128594	118/141 (84%)
		Clathrin	1424..1562	CDD:395512	106/137 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	265	1.000	Domainoid score	I1869
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2596	1.000	Inparanoid score	I29
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17940at2759
OrthoFinder	1	1.000	-	-		FOG0002324
OrthoInspector	1	1.000	-	-		otm47707
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060