DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sd and Tead4

DIOPT Version :9

Sequence 1:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_006237486.1	Gene:	Tead4 / 683522	RGDID:	1585671	Length:	513	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	262/465 - (56%)
Similarity:	306/465 - (65%)	Gaps:	82/465 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VGPGTIPSPWTPVNA--------------GPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSA 87
            :.|||.|:...|..|              .|....||:.:.||....|.:|             .
  Rat    65 LNPGTGPTGAPPSRALEGKAGIITSNEWSSPDSPEGSSISGGSQALDKPID-------------N 116

  Fly    88 DAEGVWSPDIEQSFQEALSIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHI 152
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
  Rat   117 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHI 181

  Fly   153 QVLARRKLREIQAKIKVQ-----------------------------------------FWQ--- 173
            |||||||.||||||:|.|                                         |||
  Rat   182 QVLARRKAREIQAKLKDQAAKNKALQSMAAMSSAQIVSATTFHSKMALARGPGYPAISGFWQGAL 246

  Fly   174 PGLQPSTSQDIKPFP------QPPYPAGKTSTAVSGDETGIPPSQLPWEGRAIATHKFRLLEFTA 232
            || ||..|.|:|||.      |||.|.....:.|....:...|...||:||:||:.|..:|||:|
  Rat   247 PG-QPGPSHDVKPFSQNTYAVQPPLPLPGFESPVGPTPSPSAPPAPPWQGRSIASSKLWMLEFSA 310

  Fly   233 FMEIQRD-EIYHRHLFVQLG-GKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLV 295
            |:|.|:| :.|.:||||.:. ..||:|||.|||||||||:||||||.||||:|:|:||.|||:||
  Rat   311 FLERQQDPDTYSKHLFVHISQSSPSYSDPYLETVDIRQIYDKFPEKKGGLKELFERGPSNAFFLV 375

  Fly   296 KCWADLNTDLTTGSETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVY 360
            |.||||||::  ..:...||||:|||||.||:::.|||.|||||||||||||:|::|.||..|:|
  Rat   376 KFWADLNTNI--DDQGSAFYGVSSQYESLENMIITCSTKVCSFGKQVVEKVETEFARYENGHYLY 438

  Fly   361 RIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGT 425
            ||.|||:||||||||.|||:|||:|||||||||||||||:..|:||||||||||||||:|...|.
  Rat   439 RIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGA 503

  Fly   426 THHIYRLIKE 435
            .||||||:||
  Rat   504 QHHIYRLVKE 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sd	NP_001368984.1	TEA	88..155	CDD:128703	65/66 (98%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	142/209 (68%)
Tead4	XP_006237486.1	TEA	117..184	CDD:128703	65/66 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351308
Domainoid	1	1.000	294	1.000	Domainoid score	I1440
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1589
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm46026
orthoMCL	1	0.900	-	-		OOG6_103264
Panther	1	1.100	-	-	LDO	PTHR11834
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770