DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sd and Tead1

DIOPT Version :9

Sequence 1:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_038938666.1	Gene:	Tead1 / 361630	RGDID:	1549742	Length:	546	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	231/478 - (48%)
Similarity:	275/478 - (57%)	Gaps:	131/478 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GPGTIPSPWTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQ 102
            |||:        ..|..||.|...|.||                ...|||.|. ...|::
  Rat   120 GPGS--------RRGRAGAAGRGSTAGS----------------TGWSSAGAV-AQRPEV----- 154

  Fly   103 EALSIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKI 167
                    |..|     ..|:  ||||||||||||||||||||||||||||||||:|:|||||.|
  Rat   155 --------CRAR-----SGGR--GRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREIQAAI 204

  Fly   168 KVQ-------------------------------------------------------------- 170
            ||.
  Rat   205 KVSSHIQVLARRKSRDFHSKLKVTSMDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPT 269

  Fly   171 ------FWQPGL----QPSTSQDIKPFPQPPYPAGKTSTAVSGDETGIPPSQLP------WEGRA 219
                  || ||:    ||.:|||:|||.|..||   ...||:....|..|:..|      |:||:
  Rat   270 FPGGPGFW-PGMIQTGQPGSSQDVKPFVQQAYP---IQPAVTAPIPGFEPASAPAPSVPAWQGRS 330

  Fly   220 IATHKFRLLEFTAFMEIQRD-EIYHRHLFVQLG-GKPSFSDPLLETVDIRQIFDKFPEKSGGLKD 282
            |.|.|.||:||:||:|.||| :.|::||||.:| ...|:||||||:||||||:||||||.||||:
  Rat   331 IGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKE 395

  Fly   283 LYEKGPQNAFYLVKCWADLNTDLTTGSETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVE 347
            |:.|||||||:|||.|||||.::.  .:.|.||||:|||||:||:.:.|||.|||||||||||||
  Rat   396 LFGKGPQNAFFLVKFWADLNCNIQ--DDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVE 458

  Fly   348 SEYSRLENNRYVYRIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCI 412
            :||:|.||.|:||||.||||||||||||.|||:|||:|||||||||||||.|:..|:|||||||:
  Rat   459 TEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCM 523

  Fly   413 AYVFEVAAQNSGTTHHIYRLIKE 435
            |.||||:....|..||||||:|:
  Rat   524 ACVFEVSNSEHGAQHHIYRLVKD 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sd	NP_001368984.1	TEA	88..155	CDD:128703	33/66 (50%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	144/209 (69%)
Tead1	XP_038938666.1	TEA	<162..192	CDD:413395	28/31 (90%)
Tead1	XP_038938666.1	YBD	335..543	CDD:407601	144/209 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351310
Domainoid	1	1.000	294	1.000	Domainoid score	I1440
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2418
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1589
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm46026
orthoMCL	1	0.900	-	-		OOG6_103264
Panther	1	1.100	-	-	O	PTHR11834
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810