DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sd and Tead2

DIOPT Version :9

Sequence 1:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001100982.1	Gene:	Tead2 / 308582	RGDID:	1593252	Length:	445	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	237/451 - (52%)
Similarity:	287/451 - (63%)	Gaps:	82/451 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 WTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPP 110
            ||....|.....|.::..|          ||        .|.||||||||||||||||||:||||
  Rat    16 WTGSEEGSEEGTGGSEGVG----------GD--------GSPDAEGVWSPDIEQSFQEALAIYPP 62

  Fly   111 CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIK------- 168
            |||||||||||||||||||||||||||||||||||||||||||||||||.||||:|:|
  Rat    63 CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDK 127

  Fly   169 ---------------------------------VQFWQPGLQPSTS-QDIKPFPQPPYPAGKT-- 197
                                             .|||.....|:.: .|:|||.|.|:....|
  Rat   128 AFQTMATMSSAQLISAPSLQAKLGPSGPQATELFQFWSGSSGPTWNVPDVKPFSQAPFSMSLTPP 192

  Fly   198 STAVSGDETGIPP--SQLP--------WEGRAIATHKFRLLEFTAFMEIQRDEI--YHRHLFVQL 250
            :|.:.|.|.  ||  |.||        |:.||:.|.:.:|:||:||:| ..|.:  :.|||||.:
  Rat   193 ATDLPGYEP--PPALSPLPPPAPSPPAWQARALGTARLQLVEFSAFVE-PPDAVDSFQRHLFVHI 254

  Fly   251 GGK-PSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCWADLN-----TDLTTGS 309
            ..: ||...|.||:||:|||:||||||.|||::||::||.:||:|||.|||||     .:.....
  Rat   255 SQQCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGNSG 319

  Fly   310 ETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVYRIQRSPMCEYMINF 374
            ..|.||||:|||||.|.:.|.||:.|||||||||||||:|.::||..|:|||:.|||||||::||
  Rat   320 GAGGFYGVSSQYESRELMTLTCSSKVCSFGKQVVEKVETERAQLEGGRFVYRLLRSPMCEYLVNF 384

  Fly   375 IQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGTTHHIYRLIKE 435
            :.||:.|||||||||||||||||||:..|:|||.|||.||||||:....|..||||||:::
  Rat   385 LHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sd	NP_001368984.1	TEA	88..155	CDD:128703	65/66 (98%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	127/215 (59%)
Tead2	NP_001100982.1	TEA	40..107	CDD:128703	65/66 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	1.000	Domainoid score	I1440
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1589
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm46026
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11834
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.940