DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sd and Tead3

DIOPT Version :9

Sequence 1:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001091686.1	Gene:	Tead3 / 294299	RGDID:	1311583	Length:	437	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	253/462 - (54%)
Similarity:	297/462 - (64%)	Gaps:	102/462 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 WTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPP 110
            || .|..|    |.|..:||....|.||             .||||||||||||||||||:||||
  Rat     6 WT-ANNSP----GEAREDGSEGLDKGLD-------------NDAEGVWSPDIEQSFQEALAIYPP 52

  Fly   111 CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKV------ 169
            |||||||||||||||||||||||||||||||||||||||||||||||:|:||.|..||.
  Rat    53 CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQV 117

  Fly   170 -----------------------------------------QFWQP----GLQPSTSQDIKPFPQ 189
                                                     :||..    |.||..|||||||.|
  Rat   118 SKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSRFWSSPPLLGQQPGPSQDIKPFAQ 182

  Fly   190 PPYPAGKTSTAVSGDETGIPP--------SQLP-----------WEGRAIATHKFRLLEFTAFME 235
            |.||.          :..:||        :.||           |:.|.||:.:.||||::||||
  Rat   183 PAYPI----------QPPLPPTLNSYESLAPLPPAAATAASVPAWQDRTIASSRLRLLEYSAFME 237

  Fly   236 IQRD-EIYHRHLFVQLG-GKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLVKCW 298
            :||| :.|.:||||.:| ..|:||||.||.||:|||:||||||.||||:||||||.|||:|||.|
  Rat   238 VQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFW 302

  Fly   299 ADLNTDLTTGSETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVYRIQ 363
            ||||:.:..|  .|.||||:|||.|.:::.:..||.|||||||||||||:||:||||.|:||||.
  Rat   303 ADLNSTIQEG--PGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIH 365

  Fly   364 RSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGTTHH 428
            ||||||||||||.|||:|||:|||||||||||||||:.:|::|||||.||:||||:....|..||
  Rat   366 RSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHH 430

  Fly   429 IYRLIKE 435
            :|:|:|:
  Rat   431 VYKLVKD 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sd	NP_001368984.1	TEA	88..155	CDD:128703	65/66 (98%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	141/209 (67%)
Tead3	NP_001091686.1	TEA	30..97	CDD:128703	65/66 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351309
Domainoid	1	1.000	294	1.000	Domainoid score	I1440
eggNOG	1	0.900	-	-		E1_KOG3841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1589
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm46026
orthoMCL	1	0.900	-	-		OOG6_103264
Panther	1	1.100	-	-	O	PTHR11834
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770