DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sd and tead4

DIOPT Version :9

Sequence 1:	NP_001368984.1	Gene:	sd / 32536	FlyBaseID:	FBgn0003345	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_017950998.1	Gene:	tead4 / 100144667	XenbaseID:	XB-GENE-956369	Length:	437	Species:	Xenopus tropicalis

Alignment Length:	465	Identity:	258/465 - (55%)
Similarity:	303/465 - (65%)	Gaps:	102/465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PSPWTPVNAGPPGALGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSI 107
            |:.|:  .||.|     |::.|.:.||.          ||.|.: ||||||||||||||||||:|
Frog     3 PNGWS--EAGSP-----AESTGDLGDSM----------EKSLDN-DAEGVWSPDIEQSFQEALAI 49

  Fly   108 YPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKIKV--- 169
            ||||||||||||||||||||||||||||||||||||||||||||||||||||.||||:|:|.
Frog    50 YPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKAMNM 114

  Fly   170 --------------------------------------------------QFWQPGLQPSTSQDI 184
                                                              |||..|.||..:||:
Frog   115 DQVAKDKALQSMAAMSSAQLISATAIQNKLGVSSISQAPFPPTPGTPDFFQFWPGGGQPRPTQDV 179

  Fly   185 KPFPQPPYPAGKTSTAVSGDETGIPPSQLP-----------------WEGRAIATHKFRLLEFTA 232
            |||.|||||.          ::..||..:|                 |:||:|.|.|.||:||.|
Frog   180 KPFSQPPYPL----------QSAAPPPAVPGYNASPASLSPVPSGPAWQGRSIGTPKLRLVEFLA 234

  Fly   233 FMEIQRD-EIYHRHLFVQLG-GKPSFSDPLLETVDIRQIFDKFPEKSGGLKDLYEKGPQNAFYLV 295
            |||.|.: :.|::||:|.:. ..||:||.|||:||:|||:||||||.||||:||||||.|||:||
Frog   235 FMEQQGEPDAYNKHLYVHISQSNPSYSDALLESVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLV 299

  Fly   296 KCWADLNTDLTTGSETGDFYGVTSQYESNENVVLVCSTIVCSFGKQVVEKVESEYSRLENNRYVY 360
            |.||||||.:.  .|.|.||||:|||||.||:.:.||:.|||||||||||||:||:|.||.|::|
Frog   300 KFWADLNTSIQ--DEPGVFYGVSSQYESPENMTITCSSKVCSFGKQVVEKVETEYARFENGRFLY 362

  Fly   361 RIQRSPMCEYMINFIQKLKNLPERYMMNSVLENFTILQVMRARETQETLLCIAYVFEVAAQNSGT 425
            ||.|||||||:||||.|||.|||:|||||||||||||||:..|:|||.||||||||||:....|.
Frog   363 RIHRSPMCEYLINFIHKLKQLPEKYMMNSVLENFTILQVVTNRDTQELLLCIAYVFEVSTSEHGA 427

  Fly   426 THHIYRLIKE 435
            .||||||:|:
Frog   428 QHHIYRLVKD 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sd	NP_001368984.1	TEA	88..155	CDD:128703	65/66 (98%)
sd	NP_001368984.1	YBD	224..432	CDD:407601	142/209 (68%)
tead4	XP_017950998.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1426
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	466	1.000	Inparanoid score	I1502
OMA	1	1.010	-	-		QHG52403
OrthoDB	1	1.010	-	-		D355519at33208
OrthoFinder	1	1.000	-	-		FOG0001013
OrthoInspector	1	1.000	-	-		otm49111
Panther	1	1.100	-	-	O	PTHR11834
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080