DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8509 and PTPA

DIOPT Version :9

Sequence 1:	NP_573079.1	Gene:	CG8509 / 32535	FlyBaseID:	FBgn0030696	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	XP_011517136.1	Gene:	PTPA / 5524	HGNCID:	9308	Length:	463	Species:	Homo sapiens

Alignment Length:	406	Identity:	115/406 - (28%)
Similarity:	195/406 - (48%)	Gaps:	85/406 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PVKQVRSLEDLDRWVRSQAYYDIIAYISNTSKAIQGHRLTQTFPVTEQMRRLSEIFDGLDHLIVE 91
            |.|::.::.|:.:|.|||||.|.|.:|...::.::|.:||..:.|:|.:.:|..:.:.||..|.|
Human    76 PKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEAIEKLVALLNTLDRWIDE 140

  Fly    92 HTPKIEDSYLALPFGQVRSKAYRTWMREMYQHVFSKLDE-----AINVNCKH----INELGQYLR 147
            ..|..:.|    .||   :||||||        ::||||     ...|...|    :.|:..||:
Human   141 TPPVDQPS----RFG---NKAYRTW--------YAKLDEEAENLVATVVPTHLAAAVPEVAVYLK 190

  Fly   148 RSFGNGNTLDFGPANELMFLFFLCGLFRAGILLAKDTVAAALMLFNRYVNVVRRLISTYGLTIAK 212
            .|.||...:|:|..:|..|..|||.|.:.|:|...|.:|....:||||:.|:|:|..||.:
Human   191 ESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTYRM---- 251

  Fly   213 DPACT-----IEDYYFLPYLWGAAQLSVDSPF-SPMQCEQGKIMDNYRQDFMMLEIIDHLQKTRS 271
            :||.:     ::|:.|||::||::|| :|.|: .|......|.::...:|:|.||.|..:.:.::
Human   252 EPAGSQGVWGLDDFQFLPFIWGSSQL-IDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKT 315

  Fly   272 GPLSRVALQLWSILSIPTWPQVYRGLERNYIDHVLSSFGTVEQAIFCELMSFEAVVPIMPLQRAH 336
            ||.:..:.|||:|.::|:|.:|.:||.|.|...|...:                  |:.|    .
Human   316 GPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAEVSGGW------------------PVCP----S 358

  Fly   337 LGTHLIVDEKENEDELEQKYGENR----W------------SLSP-PVSRYVSMEPESFLGFQAS 384
            |..||::.           :|:::    |            :|.| |::...|..|...:|.|.|
Human   359 LLPHLVLG-----------WGQSKRCGTWGSCFLLPHCFALNLRPAPLTLGASESPIWGMGSQRS 412

  Fly   385 KTHNKSKESEDERLWM 400
            .:|...::.:...:.|
Human   413 TSHPSPEKLQSSSVLM 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8509	NP_573079.1	PTPA	27..324	CDD:281137	98/311 (32%)
PTPA	XP_011517136.1	PTPA	76..355	CDD:281137	98/316 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158283
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5057
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1048
OMA	1	1.010	-	-		QHG54183
OrthoDB	1	1.010	-	-		D1165705at2759
OrthoFinder	1	1.000	-	-		FOG0002736
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.770