DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15602 and VPS27

DIOPT Version :9

Sequence 1:	NP_001285298.1	Gene:	CG15602 / 32533	FlyBaseID:	FBgn0030694	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_014403.3	Gene:	VPS27 / 855739	SGDID:	S000005289	Length:	622	Species:	Saccharomyces cerevisiae

Alignment Length:	329	Identity:	71/329 - (21%)
Similarity:	135/329 - (41%)	Gaps:	85/329 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SCFGCGRKYGLFCKEYGCPNCGYSFCSKCLKRPMPVP----RHAGKVHNVCLICYDKLSKLQASA 62
            :|..|.:|:.|..:::.|.:||..||.:.....:|:|    ....:|.:.|...||    |:...
Yeast   175 ACMICSKKFSLLNRKHHCRSCGGVFCQEHSSNSIPLPDLGIYEPVRVCDSCFEDYD----LKRHD 235

  Fly    63 DAEKVIDCDALPGILVTKMNLAPPSKSSDGADALFNDSLPVEELPQALVP--------SSSSSP- 118
            |::|            :|.:.....|..|     ::.....|||.:..:.        |:||.|
Yeast   236 DSKK------------SKKHRHKRKKDRD-----YSTPEDEEELIRKAIELSLKESRNSASSEPI 283

  Fly   119 ----HSKDH--KDHIDENLDSELTKRMQDYKRVDATDDEIRTRLANLTGM-------PHTKSYDK 170
                .||:.  :..|:|..|.:|...:|:..| :|.:.::|:.....:..       |..:....
Yeast   284 VPVVESKNEVKRQEIEEEEDPDLKAAIQESLR-EAEEAKLRSERQKASRQMQPQQPSPQPQPIHS 347

  Fly   171 KDLLLSTDQRNDQ--------EKMRDL-LAQFVDEAQLDQNISRQRDDSISDIERRLR-ALRD-- 223
            .||   :|:..|.        |||:.. |.:.:::::| ||::::    :...:.||. ||.|
Yeast   348 VDL---SDEEKDSIYMFASLVEKMKSRPLNEILEDSKL-QNLAQR----VFASKARLNYALNDKA 404

  Fly   224 ----TPVDSDACPSRSQMESIADNEEDDETLLQNILKKYVAESRLPE-PSESEISPIN--TESPG 281
                |.::.:.  ..|::.:|.|...:.:....|:.::|.    ||: ||:    |.|  ||:..
Yeast   405 QKYNTLIEMNG--KISEIMNIYDRLLEQQLQSINLSQQYT----LPQVPSD----PYNYLTENVQ 459

  Fly   282 NTEE 285
            |..|
Yeast   460 NPAE 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15602	NP_001285298.1	PHD_SF	2..52	CDD:304600	13/53 (25%)
VPS27	NP_014403.3	VHS_Vps27	7..149	CDD:340776
		FYVE_like_SF	169..226	CDD:333710	12/50 (24%)
		GAT_Vps27	349..432	CDD:410590	20/92 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1818
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900