DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15602 and zfyve19

DIOPT Version :9

Sequence 1:	NP_001285298.1	Gene:	CG15602 / 32533	FlyBaseID:	FBgn0030694	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_001002412.1	Gene:	zfyve19 / 436685	ZFINID:	ZDB-GENE-040718-109	Length:	431	Species:	Danio rerio

Alignment Length:	458	Identity:	112/458 - (24%)
Similarity:	165/458 - (36%)	Gaps:	152/458 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CFGCGRKYGLFCKEYGCPNCGYSFCSKCLKRPMPVPRHAGKVHNVCLICYDKLSKLQASADAEKV 67
            |:.|..|:.||.||.||.:||.||||.||.....||::......||..||..|:......||.:
Zfish     5 CYCCASKFTLFKKELGCKSCGRSFCSGCLTFNAVVPKYGNGQQKVCKQCYGNLTSSDKQTDAGR- 68

  Fly    68 IDCDALPGILVTKMNLAPPSKSSDGADALFNDSLPVEELPQALVPSSSSSPHSKDH--------- 123
                           .:||..        :...:...|..||....||.:..:||:
Zfish    69 ---------------WSPPEN--------YKKRVAAFEAKQAQQKPSSRAAGAKDNAVSLISTRG 110

  Fly   124 ---KDHI-------------------DENLDSELTKRMQDYKRVDATDDEIRTRLANLTGMPHTK 166
               :|.|                   ::.|:|.|.......:.| |:..|:..|||.|.|.| ..
Zfish   111 LSKEDQIIAERLNKLKEETKPKSIPSEKELESRLAALKAPLQPV-ASTAEMEERLAVLQGRP-AP 173

  Fly   167 SYDKKDLLLSTDQRNDQEKMRDLLAQFVDEA---------------------------------- 197
            |...:.:....|.|...|:..||:.|..:||
Zfish   174 SQAPRPVHQPPDSRTQTEQTNDLITQMTEEAAIDNQNSSSDVDAGGMLNDLNKQASVNENVDDAD 238

  Fly   198 ----QLDQNISRQRDDSISDIE-------------RRLRALRDTPVDSDACPSRSQMESIADNEE 245
                ||::..||...:::.|:.             |||..|:....||   ..:|..::...:||
Zfish   239 ASGRQLEEQKSRVLQEAMEDLRRDKHSQQMTLEMARRLARLQGQHPDS---VRQSDFQTPDSDEE 300

  Fly   246 DDETLLQNILKKYVAESRLPEPSESEI-----SPINTE--------------------------- 278
            .:|..:..::||...|:.|.|.|...|     .|:|.|
Zfish   301 TEEEAVNRVIKKLSEEAALDEASGYNIPPELSGPVNREKSKKPPSMQKSKSRPPAAAAPIRRLDD 365

  Fly   279 ----SPGNTEELPWCNICNEDADFRCHGCGGELFCTLCYKECHD--DDEEYRAHVKEKYSAPPKL 337
                ...:.||||||.|||:||..|||.|..:|:|..|:::.||  |.:::|.   ..||||.|.
Zfish   366 DDDDDDDDDEELPWCCICNQDASIRCHTCDRDLYCARCFRDGHDKYDRQDHRT---SSYSAPKKS 427

  Fly   338 KEN 340
            |:|
Zfish   428 KKN 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15602	NP_001285298.1	PHD_SF	2..52	CDD:304600	21/48 (44%)
zfyve19	NP_001002412.1	FYVE_ZFY19	4..54	CDD:277288	21/48 (44%)
zfyve19	NP_001002412.1	PRK13890	101..>177	CDD:237547	15/77 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9032
eggNOG	1	0.900	-	-		E1_KOG1818
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12435
Inparanoid	1	1.050	112	1.000	Inparanoid score	I4841
OMA	1	1.010	-	-		QHG47533
OrthoDB	1	1.010	-	-		D1355078at2759
OrthoFinder	1	1.000	-	-		FOG0006837
OrthoInspector	1	1.000	-	-		oto41177
orthoMCL	1	0.900	-	-		OOG6_108323
Panther	1	1.100	-	-	LDO	PTHR46603
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5059
SonicParanoid	1	1.000	-	-		X5729
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870