DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8974 and RNF185

DIOPT Version :9

Sequence 1:	NP_573076.1	Gene:	CG8974 / 32532	FlyBaseID:	FBgn0030693	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_689480.2	Gene:	RNF185 / 91445	HGNCID:	26783	Length:	192	Species:	Homo sapiens

Alignment Length:	223	Identity:	118/223 - (52%)
Similarity:	137/223 - (61%)	Gaps:	37/223 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PLGTSIPTNSTASELKKSNTSYSFTGDYLSGGNKADLKGGYPFGGTDTDTKANEKDKEKEHTADD 120
            |..::.|.||:|                  ||......|....||                  .|
Human     6 PSASASPENSSA------------------GGPSGSSNGAGESGG------------------QD 34

  Fly   121 SLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQ 185
            |.:|||||||||||||:|:||||||||||||||.|||||::||||||.:.:|||||||||.||.|
Human    35 STFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQ 99

  Fly   186 EDPRNKVPPRPAGQRTEPDPVPGFPGFGFGD-GFHMSFGIGAFPFGFITSTLNFGEPRPPAANRG 249
            :|||.|.||||.|||.||:...||.|||||| ||.|||||||||||...:..|..:.|||.|..|
Human   100 QDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG 164

  Fly   250 TRQYEDEQTLSKLFSYLAVVWILWLFYA 277
            |.||.|||.||:||.::|:|.:.||..|
Human   165 TPQYVDEQFLSRLFLFVALVIMFWLLIA 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8974	NP_573076.1	RING	124..169	CDD:238093	39/44 (89%)
RNF185	NP_689480.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		8/41 (20%)
		Required for ubiquitin ligase activity and protection against ER stress-induced cell death. /evidence=ECO:0000269\|PubMed:27485036	29..80		40/68 (59%)
		RING-HC_RNF185	38..80	CDD:319658	36/41 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..123		21/32 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152550
Domainoid	1	1.000	138	1.000	Domainoid score	I4857
eggNOG	1	0.900	-	-		E1_COG5574
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34298
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3357
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000717
OrthoInspector	1	1.000	-	-		otm42177
orthoMCL	1	0.900	-	-		OOG6_102074
Panther	1	1.100	-	-	LDO	PTHR12313
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	1	1.000	-	-		X682
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.780