DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8974 and rnf185

DIOPT Version :9

Sequence 1:	NP_573076.1	Gene:	CG8974 / 32532	FlyBaseID:	FBgn0030693	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_998202.1	Gene:	rnf185 / 406310	ZFINID:	ZDB-GENE-040426-1977	Length:	194	Species:	Danio rerio

Alignment Length:	214	Identity:	118/214 - (55%)
Similarity:	141/214 - (65%)	Gaps:	23/214 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 STASELKKSNTSYSFTGDYLSGGNKADLKGGYPFGGTDTDTKANEKDKEKEHTADDSLYECNICL 129
            |.|:....|::|.|..|  .:.|..|...||   ||                 |.||.:||||||
Zfish     3 SAAASESSSSSSSSSAG--AANGQSAGESGG---GG-----------------AQDSTFECNICL 45

  Fly   130 DTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPP 194
            ||:||||:|:||||||||||||||.|||||::||||||.:.:|||||||||.||.|:|||.|.||
Zfish    46 DTSKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPP 110

  Fly   195 RPAGQRTEPDPVPGFPGFGFGD-GFHMSFGIGAFPFGFITSTLNFGEPRPPAANRGTRQYEDEQT 258
            ||.|||.||:...||.|||||| ||.|||||||||||...:..|..:.|||.|..||.|:.|||.
Zfish   111 RPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAAPGTPQHTDEQF 175

  Fly   259 LSKLFSYLAVVWILWLFYA 277
            ||:||.::|::.:.||..|
Zfish   176 LSRLFLFVALLIMFWLLIA 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8974	NP_573076.1	RING	124..169	CDD:238093	38/44 (86%)
rnf185	NP_998202.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		10/33 (30%)
		Required for ubiquitin ligase activity and protection against ER stress-induced cell death. /evidence=ECO:0000250\|UniProtKB:Q96GF1	31..82		41/70 (59%)
		RING	40..85	CDD:238093	38/44 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..126		22/33 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587025
Domainoid	1	1.000	135	1.000	Domainoid score	I4932
eggNOG	1	0.900	-	-		E1_COG5574
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34298
Inparanoid	1	1.050	236	1.000	Inparanoid score	I3360
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000717
OrthoInspector	1	1.000	-	-		otm26352
orthoMCL	1	0.900	-	-		OOG6_102074
Panther	1	1.100	-	-	LDO	PTHR12313
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	1	1.000	-	-		X682
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.780