DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8974 and Rnf185

DIOPT Version :9

Sequence 1:	NP_573076.1	Gene:	CG8974 / 32532	FlyBaseID:	FBgn0030693	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_663330.2	Gene:	Rnf185 / 193670	MGIID:	1922078	Length:	228	Species:	Mus musculus

Alignment Length:	212	Identity:	116/212 - (54%)
Similarity:	138/212 - (65%)	Gaps:	19/212 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ASELKKSNTSYSFTGDYLSGGNKADLKGGYPFGGTDTDTKANEKDKEKEHTADDSLYECNICLDT 131
            |:...|..::.:.|.:..:||......|....||                  .||.:||||||||
Mouse    35 AAMASKGPSASASTENSNAGGPSGSSNGTGESGG------------------QDSTFECNICLDT 81

  Fly   132 AKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRP 196
            |||||:|:||||||||||||||.|||||::||||||.:.:|||||||||.||.|:|||.|.||||
Mouse    82 AKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRP 146

  Fly   197 AGQRTEPDPVPGFPGFGFGD-GFHMSFGIGAFPFGFITSTLNFGEPRPPAANRGTRQYEDEQTLS 260
            .|||.||:...||.|||||| ||.|||||||||||...:..|..:.|||.|..||.||.|||.||
Mouse   147 QGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLS 211

  Fly   261 KLFSYLAVVWILWLFYA 277
            :||.::|:|.:.||..|
Mouse   212 RLFLFVALVIMFWLLIA 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8974	NP_573076.1	RING	124..169	CDD:238093	39/44 (89%)
Rnf185	NP_663330.2	RING	74..119	CDD:238093	39/44 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842610
Domainoid	1	1.000	138	1.000	Domainoid score	I4825
eggNOG	1	0.900	-	-		E1_COG5574
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34298
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3348
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000717
OrthoInspector	1	1.000	-	-		otm44230
orthoMCL	1	0.900	-	-		OOG6_102074
Panther	1	1.100	-	-	LDO	PTHR12313
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	1	1.000	-	-		X682
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.780