DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8974 and rnf-5

DIOPT Version :9

Sequence 1:	NP_573076.1	Gene:	CG8974 / 32532	FlyBaseID:	FBgn0030693	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_497830.1	Gene:	rnf-5 / 175532	WormBaseID:	WBGene00004381	Length:	235	Species:	Caenorhabditis elegans

Alignment Length:	234	Identity:	94/234 - (40%)
Similarity:	118/234 - (50%)	Gaps:	62/234 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 TDTKANEKDKEKEHTADDSL-YECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCK 166
            ::|||..::.......|:|. :|||||||.|||||||:||||||||||.|||.||||.::|||||
Worm     3 SETKAPSEEPTSSSNKDESARFECNICLDAAKDAVVSLCGHLFCWPCLSQWLDTRPNNQVCPVCK 67

  Fly   167 AAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPDPVPGFPGFGF-GDG---------FHMS 221
            :|:|.:||:|:|||.. ...|||.||||||.|||:||.| ..|.||.: |||         .|.|
Worm    68 SAIDGNKVVPIYGRGG-DSSDPRKKVPPRPKGQRSEPPP-QSFAGFNWGGDGGMMGGGGPNVHFS 130

  Fly   222 FGIGA-----------------FPFGFITSTLNFGEPRPPAA----------NRGT--------- 250
            ||||.                 ||..|:.|....|.....||          |.||
Worm   131 FGIGTVNGLFPLMFMLPFIQGIFPLSFVASFFGNGNQGAAAAGGGNGGGNDGNDGTHAHTHGHTH 195

  Fly   251 -------------RQYEDEQTLSKLFSYLAVVWILWLFY 276
                         |..::|:.||.:|.|:....:.||.:
Worm   196 GPRGHGESAAPGSRMAQEEEYLSNIFKYIGFFMLFWLLF 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8974	NP_573076.1	RING	124..169	CDD:238093	36/44 (82%)
rnf-5	NP_497830.1	RING	25..70	CDD:238093	36/44 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162504
Domainoid	1	1.000	96	1.000	Domainoid score	I4598
eggNOG	1	0.900	-	-		E1_COG5574
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34298
Inparanoid	1	1.050	161	1.000	Inparanoid score	I2853
Isobase	1	0.950	-	0	Normalized mean entropy	S2074
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000717
OrthoInspector	1	1.000	-	-		otm14661
orthoMCL	1	0.900	-	-		OOG6_102074
Panther	1	1.100	-	-	LDO	PTHR12313
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	1	1.000	-	-		X682
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.730