Protein Alignment Rhp and BRO1

DIOPT Version :9

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_015241.1
• Gene: BRO1 / 856021
• SGDID: S000006005
• Length: 844
• Species: Saccharomyces cerevisiae
• Alignment Length: 652
• Identity: 140/652 - (21%)
• Similarity: 242/652 - (37%)
• Gaps: 184/652 - (28%)

  Fly   122 MIPLGLKETKEINFMEPFSDFILE---------HYSEEPSMYIDAIADMTDTRQASKTPSRDALG 177
            :..|.||:|:::::.:..|.::.:         .|.|:.:..:|.:.:..:...|..:.|...|
Yeast     5 LFDLKLKDTEKLDWKKGLSSYLKKSYGSSQWRTFYDEKATSELDHLRNNANGELAPSSLSEQNL- 68

  Fly   178 VALLFRYYNTLYYVERRFFPPDRNLGVYFEWYD-----SLTGVPSCQRTIAFEKACTLFNLGGIY 237
                 :||:.|.::..|.......|.:.|.|||     :..|:...|.|:||||:|||||:..|:
Yeast    69 -----KYYSFLEHLYFRLGSKGSRLKMDFTWYDAEYSSAQKGLKYTQHTLAFEKSCTLFNIAVIF 128

  Fly   238 TQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAPSMDLKPQVLDVLVSLMLSQARECLF 302
            ||| ||.:...:....:|  :..:|...|.::.:.|.|:||:||:.:....|.::..::|:|...
Yeast   129 TQI-ARENINEDYKNSIA--NLTKAFSCFEYLSENFLNSPSVDLQSENTRFLANICHAEAQELFV 190

  Fly   303 EKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPECWAGLVPVKAELYKAF 367
            .|| |..:..|........|:.....:..:.::..|.|. :|...|....|...|..|...||:.
Yeast   191 LKL-LNDQISSKQYTLISKLSRATCNLFQKCHDFMKEID-DDVAIYGEPKWKTTVTCKLHFYKSL 253

  Fly   368 AHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERITTADYGASDEASTSIANKLAHLKEALA 432
            :.:|....::              :|:.:|                               ||:|
Yeast   254 SAYYHGLHLE--------------EENRVG-------------------------------EAIA 273

  Fly   433 SIEEAQRLQRMCRFLKNKASLTEVM-----KEVHSKSQEELEKFRLQASAKNIEDGDLL-ERSVE 491
            .::.:  :|::...|..|..|.|.:     ||...|.|:||           |:|.|.: ..||.
Yeast   274 FLDFS--MQQLISSLPFKTWLVEFIDFDGFKETLEKKQKEL-----------IKDNDFIYHESVP 325

  Fly   492 A-----SSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAPRCVRLQKGSSLYHSVPSND 551
            |     |.|...::..|  |..|:.:|:.:            ..|.:|      .|||..:
Yeast   326 AVVQVDSIKALDAIKSP--TWEKILEPYMQ------------DVANKC------DSLYRGI---- 366

  Fly   552 NKCPLDNDDDEEHDGGYNLYKEE----------------FENFGFHVRGDAPVIIAHVE------ 594
              .|||..:.|      ::|.||                .|...|....:.|.:::.:|
Yeast   367 --IPLDVYEKE------SIYSEEKATLLRKQVEETETANLEYSSFIEFTNLPRLLSDLEKQFSDG 423

  Fly   595 -INSLADLGGIKEGD-------FIVEIAGVDVKWYSHQQVVQLIQSCGSTLELRVITPMDR--NY 649
             |.|..|..|....|       ||......|::    :|:.:::......||:....|.|:  |.
Yeast   424 NIFSNTDTQGQLMRDQIQTWCKFIQTNEFRDIE----EQMNKIVFKRKQILEILSALPNDQKENV 484

  Fly   650 LKPLSSKGSLSTLSAASSSGISSGFPSPTSIAAKPKLHLKTSSSSRPAGSVSSSSWNPF----RR 710
            .|..||      |.|||:        |...:.|..|.|:...:.....|.:    |..|    |.
Yeast   485 TKLKSS------LVAASN--------SDEKLFACVKPHIVEINLLNDNGKI----WKKFDEFNRN 531

  Fly   711 TP 712
            ||
Yeast   532 TP 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	92/416 (22%)
		PDZ_signaling	570..642	CDD:238492	18/101 (18%)
BRO1	NP_015241.1	BRO1_ScBro1_like	5..347	CDD:185765	91/412 (22%)
		V_ScBro1_like	368..702	CDD:185750	42/194 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770