Protein Alignment Rhp and RIM20

DIOPT Version :10

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_014918.1
• Gene: RIM20 / 854449
• SGDID: S000005801
• Length: 661
• Species: Saccharomyces cerevisiae
• Alignment Length: 604
• Identity: 117/604 - (19%)
• Similarity: 213/604 - (35%)
• Gaps: 189/604 - (31%)

  Fly   122 MIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRYYN 186
            ::.:.||.|.|::|....|..|.....:..|.:...|..:.|.|..:..|.....|::.|..||.
Yeast     4 LLAIPLKRTLEVDFATELSKLIDTTSFQTASFFQSDILKVVDARNNAIAPDISIDGLSALKEYYV 68

  Fly   187 TLYYVERRFFPPDRNLGVYFEWYDSLT--GVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTTE 249
            .|..:|::|    .|..:.|.|:.:|:  ...:.|.::.:||...::|:|.:|:.:....:....
Yeast    69 ILLQLEKKF----PNNQIEFTWFQTLSQKSRGTSQYSLQWEKLTIIYNIGCMYSLLALNSNNDAA 129

  Fly   250 RGLDLAVDSFLRAAGVFRHIYDTFTN---APSMDLKPQVLDVLVSLMLSQAREC----------- 300
            ..|..:...|..|||.|:|:.|...|   .|.:|  ...|:.|.||||:||:||
Yeast   130 ESLKTSCLYFQNAAGCFKHVLDHQKNLETIPVVD--DATLNALTSLMLAQAQECFWFKAVQDKHK 192

  Fly   301 --LFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPECWAGLVPVKAEL 363
              |..||..||  :...|:|..|.            :..|.|:::         |...:..|...
Yeast   193 DSLIAKLSQQI--VDFYCEAINDA------------QRGKLIRSD---------WINHLKAKKAY 234

  Fly   364 YKAFAHFYKARSIDATDEL---------------KASKSSQKNQESFIGNS-QEVERITTADYGA 412
            :.|..::..|.|.:...:.               :::.|||...::.:.:| :|.:|.....|
Yeast   235 FSAVTYYRIALSFNEKKQFGNVVKALQMGLQFINESTLSSQAKFKTVVESSLKEAQRDNEFIY-- 297

  Fly   413 SDEASTSIANKLAHLKEA-----------LASIEEAQRL-----------------QRMCRFLKN 449
                ...:.::|..:|.|           |.||::.:.|                 :|...:::.
Yeast   298 ----LQEVPSELPSIKPALMVKPSSSATLLPSIKKDETLFKDLIPIEVMEYCTAYNERQDEYVEQ 358

  Fly   450 K-----ASLTEVMKEVHSKSQ--------EELEKFRLQASAKNIEDGDLLERSVEAS-SKFTLSL 500
            :     |||.:::||..:..|        .|.|....|||..|:.   :..::|:.. ......|
Yeast   359 RVTNPLASLNKLLKESLTTFQIPQGLTKVSEAELSHYQASLNNLL---INNKNVQVQLDNIEQIL 420

  Fly   501 TGPDFTSHKVKDPFKRLGPIAIFSARRHWTAPRCVR---------------LQKGSS-------L 543
            ....||.::::          :.....:||.|....               |.:||:       |
Yeast   421 NEEAFTDNQLR----------LKHGTLNWTLPESSTTNTAYYEKLKKLRGYLDEGSAIDKQTNEL 475

  Fly   544 YHSVPSN---------DNKCPLDN-------------DDDEEHDGGYNL-------YKE----EF 575
            :.|:..|         ::..||.|             |........|.:       ||:    :|
Yeast   476 FQSIDKNLIGSEIRLPESNDPLTNKIKMIIQERNDYIDRTRRKSSEYRILPKIITSYKKNGTVDF 540

  Fly   576 ENFGFHVRGDAPVIIAHVE 594
            |          |:.|.|::
Yeast   541 E----------PIFIGHLK 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	96/467 (21%)
		PDZ_canonical	578..642	CDD:483948	3/17 (18%)
RIM20	NP_014918.1	BRO1_ScRim20-like	3..343	CDD:185764	79/373 (21%)
		V_Alix_like	338..645	CDD:185746	38/235 (16%)