DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rhp and RHPN2

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_149094.3	Gene:	RHPN2 / 85415	HGNCID:	19974	Length:	686	Species:	Homo sapiens

Alignment Length:	682	Identity:	261/682 - (38%)
Similarity:	382/682 - (56%)	Gaps:	66/682 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FVRGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRDTVALELSFVNSNLQ 95
            |.:|.:|.|.|.||||||:|..||::|.|.:|:|.|||||.|..:|.|:|:.|.||||||||:||
Human    21 FRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNSKVREQVRLELSFVNSDLQ 85

  Fly    96 LLKEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIAD 160
            :|||:|..||.||.:||:......:|:|||||||||:::|.....|||||||||:..:|.|.|||
Human    86 MLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKETKDVDFAVVLKDFILEHYSEDGYLYEDEIAD 150

  Fly   161 MTDTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSLTGVPSCQRTIAFE 225
            :.|.|||.:|||||..||.||..|:..|.:||.|||||.|.:|:.|.|||||||||..|:.:..|
Human   151 LMDLRQACRTPSRDEAGVELLMTYFIQLGFVESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLE 215

  Fly   226 KACTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAPSMDLKPQVLDVLV 290
            ||..|||.|.:|||||.|.||.|:.||:.|:|:|.|||||..::.||||:.||.|:.|.:|.|||
Human   216 KASVLFNTGALYTQIGTRCDRQTQAGLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLV 280

  Fly   291 SLMLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPECWAG 355
            .:||:||:|.:|||:.|  ..:.::......:|.|||::...|.::|..:........:|..||.
Human   281 KMMLAQAQESVFEKISL--PGIRNEFFMLVKVAQEAAKVGEVYQQLHAAMSQAPVKENIPYSWAS 343

  Fly   356 LVPVKAELYKAFAHFYKARSIDATDELKASKSSQKNQESFIGNSQE--VERITTADYGASDEAST 418
            |..|||..|.|.||::.|  |...|......:...:||..:....:  .|.:|......:|:...
Human   344 LACVKAHHYAALAHYFTA--ILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLKNDQQRR 406

  Fly   419 SIANKLAHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVHSKSQEELEKFRLQASAKNIEDG 483
            .:..  :||:.|:|..||:.|...:|:.|::    .||:::|...:|   |:.|| ..|::.|:.
Human   407 QLGK--SHLRRAMAHHEESVREASLCKKLRS----IEVLQKVLCAAQ---ERSRL-TYAQHQEED 461

  Fly   484 DLLE----RSVEASSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAPRCVRLQKGSSLY 544
            |||.    .||.|.::..:.:..|.|:...|.|.|::|||:::|||.:.||.||.:|...
Human   462 DLLNLIDAPSVVAKTEQEVDIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTA----- 521

  Fly   545 HSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINSLADLGGIKEGDF 609
                             ||.|            .||.:||:|||.:..::....|.:.|.:|||:
Human   522 -----------------EEGD------------LGFTLRGNAPVQVHFLDPYCSASVAGAREGDY 557

  Fly   610 IVEIAGVDVKWYSHQQVVQLIQSCG-STLELRVITPMDRNYLKPLSSKGSLSTLSAASSSGISSG 673
            ||.|..||.||.:..:|::|::|.| ..:|::|::.:|        |..|:...||..|.|:...
Human   558 IVSIQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLD--------STSSMHNKSATYSVGMQKT 614

  Fly   674 FPSPTSIAAKPKLHLKTSSSSRPAGSVSSSSW 705
            :   :.|........||..:.:.:..:|..||
Human   615 Y---SMICLAIDDDDKTDKTKKISKKLSFLSW 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	47/83 (57%)
		BRO1_Rhophilin	122..514	CDD:185767	159/397 (40%)
		PDZ_signaling	570..642	CDD:238492	24/72 (33%)
RHPN2	NP_149094.3	HR1_Rhophilin-2	27..108	CDD:212024	46/80 (58%)
		Interaction with Rho	46..66		10/19 (53%)
		BRO1_Rhophilin_2	112..496	CDD:185772	159/397 (40%)
		PDZ_signaling	514..591	CDD:238492	30/110 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144350
Domainoid	1	1.000	284	1.000	Domainoid score	I1633
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12407
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1853
Isobase	1	0.950	-	0	Normalized mean entropy	S4559
OMA	1	1.010	-	-		QHG49710
OrthoDB	1	1.010	-	-		D286986at33208
OrthoFinder	1	1.000	-	-		FOG0003216
OrthoInspector	1	1.000	-	-		otm42233
orthoMCL	1	0.900	-	-		OOG6_105514
Panther	1	1.100	-	-	O	PTHR23031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5869
SonicParanoid	1	1.000	-	-		X1868
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	17	16.790