DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rhp and ptpn23b

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001038393.1	Gene:	ptpn23b / 560417	ZFINID:	ZDB-GENE-060503-179	Length:	1229	Species:	Danio rerio

Alignment Length:	511	Identity:	122/511 - (23%)
Similarity:	211/511 - (41%)	Gaps:	98/511 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 MPMIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRY 184
            ||||.|.|||..:..|......:|..:|.|.|..|.:|:..:...||:.....||..|...|.:|
Zfish     7 MPMIWLELKEAGDFEFSPTVRQYIEINYGENPENYSEALKRLEQLRQSVVNIPRDFEGCNTLRKY 71

  Fly   185 YNTLYYVERRF-FPPDRNLGVYFEWYDSLTGVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTT 248
            ...|::::.|. ....:...:...|.|..||.......|.:|.||.|:|||.:::.:||..:|.:
Zfish    72 CGQLHFLQSRVPMATGQEAALPVTWTDIFTGRNITHEDINYEHACVLYNLGALHSLLGAVDNRLS 136

  Fly   249 ERGLDLAVDSFLRAAGVFRHIYDTFTNAPSMDLKPQVLDVLVSLMLSQARECLFEKLQLQIEAMS 313
            |.|:.::...|..:||.|.::.|.::::.|.|:..|.|.:.:||||:||:|||.||..|
Zfish   137 EEGMKVSCTHFQCSAGAFAYLRDHYSHSYSSDMSSQALSINISLMLAQAQECLLEKTLL------ 195

  Fly   314 HDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPEC--------WAGLVPVKAELYKAFAHF 370
             |.:....:|...||:...|.:..:.::.:       ||        |..|:.:|...:.|..|.
Zfish   196 -DNRKSHLIAKICAQVCDYYKDCLRVLENS-------ECVPGRIQKEWRKLINMKISYFSAITHL 252

  Fly   371 YKARSID----------------------------ATDELKASKSSQKNQESFIGNSQEVERITT 407
            :..:..:                            :.|:|..:....|.|...|   ||..:.|.
Zfish   253 HMGKQSEEQQKYGEAVSVCLCAFSALFDLVAYFQFSLDKLNEAIKQSKGQPETI---QEALKFTM 314

  Fly   408 ----ADYGASDEASTSIANKLAHLKEALASIEEAQRLQRMCRFLKNKASLTE------------- 455
                ..|.::.:.:..|.::.....:.|.:::.|..::.:      ..|||:
Zfish   315 DVIGGKYNSAKKDNDFIYHESVPSLDTLGAVKGASLVKPL------PVSLTDQSVTGPDLFSKLV 373

  Fly   456 --VMKEVHSKSQEELEKFRLQASAKNIED-GDLLERSVEASSKFTLSLTGPDFTSHKVKDPFKRL 517
              ...|..|...||..|. |:.....||| ..:||:.:|:.|..:|         :|: |.||.|
Zfish   374 PMATHEASSLYSEEKAKL-LRDIVSKIEDKNQILEKFMESLSSDSL---------YKI-DMFKSL 427

  Fly   518 GPIAI-----FSARRHWTAPRCVR-LQKGSSLYHSVPSNDNKCPLDNDDDEEHDGG 567
             |.|:     |.:.|..|....|: :|..|::|..|.|:.::.....::||..:.|
Zfish   428 -PDALLEKCAFLSVRPDTVKNLVQAMQALSNVYTDVGSSLDEVRSALEEDEAGEKG 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	103/448 (23%)
		PDZ_signaling	570..642	CDD:238492
ptpn23b	NP_001038393.1	BRO1_HD-PTP_like	2..369	CDD:185762	89/384 (23%)
		V_HD-PTP_like	374..708	CDD:185747	33/121 (27%)
		ALIX_LYPXL_bnd	426..711	CDD:290660	15/58 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910