DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rhp and Rhpn2

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_082173.3	Gene:	Rhpn2 / 52428	MGIID:	1289234	Length:	686	Species:	Mus musculus

Alignment Length:	681	Identity:	260/681 - (38%)
Similarity:	379/681 - (55%)	Gaps:	102/681 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ENEDDEKLNELSFCFVRGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRD 81
            |.|.|:       .|.:|.:|.|.|.||||||:|..||::|.|.:|:|.|||||.|..:|:|:|:
Mouse    14 EKEGDD-------YFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNQKVRE 71

  Fly    82 TVALELSFVNSNLQLLKEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEH 146
            .|.||||||||:||:|||:|..||.||.:||.......:|:||||||||||::|...|.||||||
Mouse    72 QVRLELSFVNSDLQMLKEELEGLNISVGVYQGTEEAFTIPLIPLGLKETKEVDFSIVFKDFILEH 136

  Fly   147 YSEEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDS 211
            |||:..:|.|.|||:.|.|||.:|||||..||.||..|:..|.:||.|||||.|::|:.|.||||
Mouse   137 YSEDSYLYEDDIADLMDLRQACRTPSRDEAGVELLMSYFIQLGFVESRFFPPTRHMGLLFTWYDS 201

  Fly   212 LTGVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNA 276
            .||||..|:|:..|||..|||:|.:|||||.|.:|.|:.||:.|||:|.|||||..::.:|||:.
Mouse   202 FTGVPVSQQTLLLEKASVLFNIGALYTQIGTRCNRQTQAGLESAVDAFQRAAGVLNYLKETFTHT 266

  Fly   277 PSMDLKPQVLDVLVSLMLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQ 341
            ||.|:.|.:|.|||.:||:||:|.:|||:.|  ..:.::......:|.|||:::..|.::|..:.
Mouse   267 PSYDMSPAMLSVLVKMMLAQAQESVFEKVCL--PGIQNEFFVLVKVAQEAAKVAEAYRQLHAAMS 329

  Fly   342 ANDTHTYLPECWAGLVPVKAELYKAFAHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERIT 406
            .......:|..||.:..|||..|.|.||:: |.::....:||.. :.:.:||..:  ||..:|:
Mouse   330 QEPVKENIPYSWASVAYVKAYHYGALAHYF-AATLLIDHQLKPG-ADEDHQEKCL--SQLYDRM- 389

  Fly   407 TADYGASDEASTSIAN-KLA---------HLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVH 461
                   .|..|.:|. |.|         ||..|:...||:.|...:|:.|::...|.:|:...|
Mouse   390 -------PEGMTPLATLKNAGQRVLLGKGHLHRAIGFHEESLREANLCKKLRDIQVLRDVLSAAH 447

  Fly   462 SKSQEELEKFRLQASAKNIEDGDLL------------ERSVEASSKFTLSLTGPDFTSHKVKDPF 514
            .::|.:..:.|        ||.|||            ||.|:        :|.|||:...|.|.|
Mouse   448 QRTQLKHTQHR--------EDDDLLNLIDAPDVLPKTEREVK--------ITFPDFSKVTVTDFF 496

  Fly   515 KRLGPIAIFSARRHWTAPRCVRLQKGSSLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFG 579
            ::|||:::|||.:.|:.||        .::.:|...|                          .|
Mouse   497 QKLGPLSVFSASKRWSPPR--------GIHFTVEEGD--------------------------LG 527

  Fly   580 FHVRGDAPVIIAHVEINSLADLGGIKEGDFIVEIAGVDVKWYSHQQVVQLIQSC-GSTLELRVIT 643
            |.:||:.||.:..::.:..|.|.|.||||:||.|.|||.||.:..:|::|::|. |..:|::|::
Mouse   528 FTLRGNTPVQVHFLDPHCSASLAGAKEGDYIVSIQGVDCKWLTVSEVMKLLKSFGGEEVEMKVVS 592

  Fly   644 PMDRNYLKPLSSKGSLSTLSAASSSGISSGF 674
            .:|        |..|:....|..|.|:...:
Mouse   593 LLD--------STSSMHNKCATYSVGMQKTY 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	47/83 (57%)
		BRO1_Rhophilin	122..514	CDD:185767	163/413 (39%)
		PDZ_signaling	570..642	CDD:238492	26/72 (36%)
Rhpn2	NP_082173.3	HR1_Rhophilin-2	27..108	CDD:212024	46/80 (58%)
		Interaction with Rho. /evidence=ECO:0000250	46..66		10/19 (53%)
		BRO1_Rhophilin_2	112..496	CDD:185772	163/413 (39%)
		PDZ_signaling	522..591	CDD:238492	27/94 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834488
Domainoid	1	1.000	287	1.000	Domainoid score	I1586
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12407
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1791
Isobase	1	0.950	-	0	Normalized mean entropy	S4559
OMA	1	1.010	-	-		QHG49710
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003216
OrthoInspector	1	1.000	-	-		otm44287
orthoMCL	1	0.900	-	-		OOG6_105514
Panther	1	1.100	-	-	O	PTHR23031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5869
SonicParanoid	1	1.000	-	-		X1868
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.780