Protein Alignment Rhp and pdcd6ip

DIOPT Version :10

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: XP_012809018.2
• Gene: pdcd6ip / 496474
• XenbaseID: XB-GENE-1194420
• Length: 875
• Species: Xenopus tropicalis
• Alignment Length: 661
• Identity: 147/661 - (22%)
• Similarity: 251/661 - (37%)
• Gaps: 195/661 - (29%)

  Fly   123 IPLGLKETKEINFMEPFSDFILEHY--SEEPSMYIDAIADMTDTRQAS--KTPSRDALGVALLFR 183
            |.:.||:|.|::.::|.|.:|...|  .|:.:.|..|:.::...|:::  :...:....:..:.|
 Frog     5 ISVPLKKTSEVDLVKPLSKYIHNTYPSGEDQTEYCRAVEELNKLRKSAVGRPLDKHETSLETVMR 69

  Fly   184 YYNTLYYVERRFFPPDRNLGVYFEWYD-----SLTG------VPSCQRTIAFEKACTLFNLGGIY 237
            ||:.|..||.:|...:..|.:.|.|.|     |:.|      :||    :.:||.|.|||:|.:.
 Frog    70 YYDQLCSVEPKFPFTESQLCLTFTWKDAFDKGSIFGGSVKLALPS----LGYEKTCVLFNIGALA 130

  Fly   238 TQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNA----PSMDLKPQVLDVLVSLMLSQAR 298
            :||.:..:...:..|..|...:..|:|.|.||.||..::    |::|:.|..:..|..:||:||:
 Frog   131 SQIASEQNLDNDEALKAASKFYQLASGAFSHIKDTVLSSLNRDPTVDISPDTVGTLSLIMLAQAQ 195

  Fly   299 ECLFEKLQLQIEAMSHDCQAFRD------LAGEAAQISHEYNEMHKNIQANDT---HTYLPECWA 354
            |..|.|             |.||      :|..|.|.:..|.:..|..|..||   :.|..|.:.
 Frog   196 EVFFLK-------------ATRDKMKDALIAKLANQAADYYGDAFKQCQYKDTLSKYFYFQEVFP 247

  Fly   355 GLVPVKAELYKAFAHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERITTADYGASDEASTS 419
             ::..|..:.:|.|.::  :|:.|           |.|:.|               |
 Frog   248 -ILAAKHCIMQAHAAYH--QSVLA-----------KQQKKF---------------G-------- 275

  Fly   420 IANKLAHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVHSKSQEELEKFRLQASAKNIED-G 483
                           ||..|||.          .::::|.|.|:..|.:          |::| .
 Frog   276 ---------------EEIGRLQH----------ASDLVKTVSSRYDEYV----------NVKDLA 305

  Fly   484 DLLERSVEASSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAPRCVRL-QKGSSLYHS- 546
            |.:.|::.|:.|      ..||..|......|.|.||...|..:  ..|..|.| ||.:.|:..
 Frog   306 DKINRALTAAKK------DNDFIYHDRVPDLKDLDPIGKASLVK--PTPINVPLSQKYTDLFEKM 362

  Fly   547 VPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGDAPV----IIAHVEI-NSLADLGG--- 603
            ||....:|..          .||..:.|..|.......||..    ::|.:.: .::.|:.|
 Frog   363 VPLAIQQCLT----------VYNQRRAELINATIAQMRDATTFANGVLASLNLPAAIEDVSGDSV 417

  Fly   604 ----IKEGDFIVEIAGVDVKWYSHQQVVQLIQSCGSTLE---------LRVI------------- 642
                :.:...|:|..|:       |.:.|||:.....|:         ::.:
 Frog   418 PQSILNKSKTIIEQGGI-------QTIDQLIRDLPELLQRNKEILDESVKFLDEEEATDNDLKAK 475

  Fly   643 -------TPMDRNYLKPLSSKGS--LSTLSAA--SSSGISSGFP---SPTSIAAKPKLHLKTS-S 692
                   ||....| |||.|:|:  .|.|..|  :.:.:...:.   ...:|..||:..|..: .
 Frog   476 FKDRWQRTPSTELY-KPLRSEGNNFRSVLDKAIGADAVVKERYQCHREAIAILCKPEAELNAAIP 539

  Fly   693 SSRPAGSVSSS 703
            |:.||.::..|
 Frog   540 SANPAKTMQGS 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	97/419 (23%)
		PDZ_canonical	578..642	CDD:483948	13/84 (15%)
pdcd6ip	XP_012809018.2	BRO1_Alix	2..349	CDD:185763	103/440 (23%)
		V_Alix	364..702	CDD:185748	38/205 (19%)