DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rhp and rhpn1

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001008116.1	Gene:	rhpn1 / 493478	XenbaseID:	XB-GENE-970431	Length:	706	Species:	Xenopus tropicalis

Alignment Length:	717	Identity:	275/717 - (38%)
Similarity:	396/717 - (55%)	Gaps:	93/717 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRDTVALELSFVNSNLQLL 97
            :|.||.|.|.|||||:||.::|::||||:|:|||||||::||:|.|:|:|||||||:||||||||
Frog    23 KGCDPFAQTQRSKLQHRRARINQQINKEMRMRAGAENLFRATTNHKVRETVALELSYVNSNLQLL 87

  Fly    98 KEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIADMT 162
            ||:|.||||||||||:||....:||||||||||||::..:...|||:.||.::.::|...|.:..
Frog    88 KEELEELNSSVEIYQNESDAINVPMIPLGLKETKELDLTDALKDFIVHHYGDDGTLYDKEIREFM 152

  Fly   163 DTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSLTGVPSCQRTIAFEKA 227
            |.|||.:||||...|:.||..|||.||:::.|||||::.|||:|.|||||||||||||.:||||.
Frog   153 DLRQAMRTPSRSDAGIELLMEYYNQLYFLDNRFFPPNKPLGVFFHWYDSLTGVPSCQRALAFEKG 217

  Fly   228 CTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAPSMDLKPQVLDVLVSL 292
            ..|||:|.:|||||||.||.:..|:|.|:|:|.:|||.|.::.:.|:||||:|:....|.:||.|
Frog   218 SVLFNMGALYTQIGARQDRLSVEGVDTAIDAFQKAAGCFSYLKENFSNAPSLDMSTASLSMLVRL 282

  Fly   293 MLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPECWAGLV 357
            |::|.:||:|||..||........|.  ..|.|||::...|..:::.:.......|:|..|:.:|
Frog   283 MVAQVQECIFEKFVLQNPRSDFFTQL--QAAQEAARVEEVYTLVYRTMTQPPVKDYIPFSWSTMV 345

  Fly   358 PVKAELYKAFAHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERITTADYGAS------DEA 416
            .||||.::|.:|:|.|.::  .|...||::..|.||.......     .||..|.|      |..
Frog   346 HVKAEHFRALSHYYAACAL--CDYSTASEAEVKTQEKAFSQFH-----VTAPEGPSVGFVLQDPE 403

  Fly   417 STSIANKLAHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVHSKSQEELEKFRLQASAKNIE 481
            ......| ||||:|:...|||.|:..:.:.|:....|.||:...|.:|   |.|:      .:|:
Frog   404 ERRKLGK-AHLKKAIMKHEEAMRIHVLSKILRKMDILQEVLTLTHKQS---LSKY------SDID 458

  Fly   482 DGDLLERSVEASSKFTLSLTGPD-----FTSHKVKDPFKRLGPIAIFSARRHWTAPRCVRLQKGS 541
            ..:....:.||.....::...|:     |:..|..|.|.||||:::|||:..|..|:.|.|:||
Frog   459 HEEDFFETGEAPDIQPITCQRPEIKTPVFSKVKATDIFHRLGPLSVFSAKHKWRPPQKVHLEKG- 522

  Fly   542 SLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINSLADLGGIKE 606
                              ||               .|||.:||||||::|.:.....|...|:.|
Frog   523 ------------------DD---------------GFGFTLRGDAPVLVAGIVPGGCAAEAGVME 554

  Fly   607 GDFIVEIAGVDVKWYSHQQVVQLIQSCGST-LELRVITPMDRNYLKPLSSKGSLSTLS-AASSSG 669
            ..:||.::|.|.:|..|.||||.::..|.. :::.|:  :.:|....:...|..|:.| ...:.|
Frog   555 NSYIVSVSGADCRWAKHAQVVQQLKDAGEDGVDIEVV--VFQNPETQIMLWGPQSSFSWQRGAHG 617

  Fly   670 ISSGFPSPTSIAAKPKLHL--------------------KTSSSSRPAGSVSSSS---WNPFRRT 711
            .:...|......|.|.|.|                    |.::.....||.|:|:   |:  :|:
Frog   618 WAGHVPQQWDYNASPSLSLSQVVDKRASMLTACELLRGNKENNKKSILGSKSASALRLWS--KRS 680

  Fly   712 PS 713
            .|
Frog   681 KS 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	60/83 (72%)
		BRO1_Rhophilin	122..514	CDD:185767	155/402 (39%)
		PDZ_signaling	570..642	CDD:238492	24/72 (33%)
rhpn1	NP_001008116.1	HR1_Rhophilin-1	24..108	CDD:212023	60/83 (72%)
		BRO1_Rhophilin_1	112..496	CDD:185771	155/402 (39%)
		PDZ_signaling	514..591	CDD:238492	31/110 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1563
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	450	1.000	Inparanoid score	I1577
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286986at33208
OrthoFinder	1	1.000	-	-		FOG0003216
OrthoInspector	1	1.000	-	-		otm49461
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5869
SonicParanoid	1	1.000	-	-		X1868
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.090