DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rhp and pdcd6ip

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_005159794.1	Gene:	pdcd6ip / 406669	ZFINID:	ZDB-GENE-040426-2678	Length:	871	Species:	Danio rerio

Alignment Length:	695	Identity:	152/695 - (21%)
Similarity:	278/695 - (40%)	Gaps:	168/695 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 IPLGLKETKEINFMEPFSDFILEHY--SEEPSMYIDAIADMTDTRQASKTPSRDALG-------- 177
            |.:.||::.|::.::|.|.|:...|  .||.:.|:.|:.::...|       :.|||
Zfish     5 ISVPLKKSSEVDLVKPLSKFVTATYPPGEEQAEYLRAVDELNKLR-------KSALGRPLDKHES 62

  Fly   178 -VALLFRYYNTLYYVERRF-FPPDRNLGVYFEWYD-----SLTG--VPSCQRTIAFEKACTLFNL 233
             :.:|.|||:.|..:|.:| ||   .|.:.|.|.|     ||.|  |.....::.:||.|.|||:
Zfish    63 SLEILLRYYDQLCAIEPKFPFP---ELCLTFTWKDAFDKGSLFGGSVKLALASLGYEKTCVLFNV 124

  Fly   234 GGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNA----PSMDLKPQVLDVLVSLML 294
            |.:.:||.:..:...:.||..|...:..|:|.|.||.||..:|    |:||:.|:.:..|..:||
Zfish   125 GALASQIASEQNLDNDEGLKTAAKFYQLASGAFAHIKDTVLSALNREPTMDISPETVGTLSQIML 189

  Fly   295 SQARECLF-----EKLQLQIEAMSHDCQAFRDLAGEA-AQISHEYN------------------- 334
            |||:|...     :|::..|.|...:..|  |..|:| .|..::.|
Zfish   190 SQAQEVFVLKATSDKMKDAIVAKLANQAA--DYYGDAFKQCQYKENLPKYFYFQDVLPVLAAKHC 252

  Fly   335 ------EMHKNIQANDTHTYLPECWAGLVPVKAELYKAFAHFYK--ARSIDATDELKASKSSQKN 391
                  |||::..||....:..|. |.|...: ||.|..|..|.  ....|.:|::..:.::.|.
Zfish   253 MMQATAEMHQSALANQKKKFGEEI-ARLQHAQ-ELVKTAASRYDEYVNVKDLSDKINRALTAAKK 315

  Fly   392 QESFIGNS-----QEVERITTADYGASDEASTSIANKLAHLKEAL-----------ASIEEAQRL 440
            ...||.:.     :::|.|..|....:....|.::.|...|.|.:           |:..:|:.:
Zfish   316 DNDFIYHDRVPEVKDLEHIGKASLVKATAVQTPLSQKFTDLFEKMVPMAVQQSVSAANSRKAETV 380

  Fly   441 QRMCRFLKNKASLTE-------------------VMKEVHSKSQEELEKFRLQASAKNIED-GDL 485
            .|:...::...:|..                   |.:.:..||:..:::..||:..:.|:| .:|
Zfish   381 NRLIGSMREATNLCNGVLASLNLPAALEDLSGDAVPQSILEKSRALIQQGGLQSIEQLIKDLPEL 445

  Fly   486 LERSVEASSKFTLSLTGPDFTSHKVKDPFKR----------LGPI----------------AIFS 524
            |:|:.|...:....|...:.|.::::..|.:          ..|:                |...
Zfish   446 LQRNREILDESLKMLDDEEATDNELRGKFNQRWNRTPSGDLYKPLRAEGNNFRNILDKAVQADQV 510

  Fly   525 ARRHWTAPRCVRL----QKGSSLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGD 585
            .|..:|| .|..:    :..:.|..::||.:....|...:      ..|:.:.:..... .|:.:
Zfish   511 VRERYTA-HCEMIALLCKPENELSAAIPSANPAKTLQGSE------VVNVLRSQLAQLD-EVKRE 567

  Fly   586 APVIIAHVE----------INSLADLGGIKEGDFIVEIAGVDVKWYSH-QQVVQLIQSCGSTLEL 639
            ..|:...|:          :.:||..|.|.|.  ::..:.:|.::.|| |:|.|.::.....|..
Zfish   568 REVLEGEVKSVTFDLTAKFLTALAQDGAINEE--VMTSSELDARYGSHNQRVQQNLRRQEELLSQ 630

  Fly   640 RVITPMDRNYLKPLSSKGS-----LSTLSAAS------SSGISSG 673
            ..::..:.:.||..:|:.:     |..|::|.      ||.|..|
Zfish   631 IQVSHQEFSALKQSNSEANTREDVLKKLASAHDSYIEISSNIKEG 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	115/482 (24%)
		PDZ_signaling	570..642	CDD:238492	15/82 (18%)
pdcd6ip	XP_005159794.1	BRO1_Alix	2..347	CDD:185763	94/355 (26%)
		V_Alix	362..700	CDD:185748	54/324 (17%)
		ALIX_LYPXL_bnd	415..703	CDD:290660	50/271 (18%)
		RCR	<783..849	CDD:304939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910