Protein Alignment Rhp and rhpn2

DIOPT Version :10

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_957472.1
• Gene: rhpn2 / 321330
• ZFINID: ZDB-GENE-030131-9927
• Length: 683
• Species: Danio rerio
• Alignment Length: 716
• Identity: 256/716 - (35%)
• Similarity: 388/716 - (54%)
• Gaps: 103/716 - (14%)

  Fly    31 FVRGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRDTVALELSFVNSNLQ 95
            |.:|.:|.|.|.||||||:|..||::|.|::|:|||||||.|||||.|:|:.|.||||:|||:||
Zfish    21 FKKGCNPFAQTGRSKLQNKRAVLNQKIIKQMRMRAGAENLLKATSNNKVREQVVLELSYVNSDLQ 85

  Fly    96 LLKEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIAD 160
            ||.|||..||||||:||:...:..:|:|||||||||:::|..|..|||||||||:.|.:.:.|.|
Zfish    86 LLMEQLEGLNSSVEVYQNVQESSSIPLIPLGLKETKDVDFSVPLKDFILEHYSEDGSNFQNQIDD 150

  Fly   161 MTDTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSLTGVPSCQRTIAFE 225
            :.|.|||.:||||:..||.|:..|::.|.::|.|||.|.|.:|::|.||||.||:|.||..|:.|
Zfish   151 LMDLRQACRTPSRNNSGVDLIANYFSQLSFLETRFFSPTRQIGIFFTWYDSFTGMPVCQNNISLE 215

  Fly   226 KACTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAPSMDLKPQVLDVLV 290
            ||..|||:..:|:|||.|.||.|..||:.|:.:|.::|||...:.:|||:.||.|:.|.:|.:|.
Zfish   216 KASMLFNMAALYSQIGTRADRQTLAGLEDAIAAFQKSAGVLHLLKETFTHTPSYDMSPAMLSMLF 280

  Fly   291 SLMLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPECWAG 355
            .|||:||:|||||  |:.:..:.::......:|.|||:::..|.::|:::........:|..|..
Zfish   281 RLMLAQAQECLFE--QITLPGIRNEFFCLLKMAQEAAKVAETYAQVHQSMIETPITKNVPFFWTT 343

  Fly   356 LVPVKAELYKAFAHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERITTADYGASDEASTS- 419
            :..:|...|.:.||::.:.:: ...:|..|....|.           |:..:..|.|..|..:.
Zfish   344 MSQLKINHYNSLAHYFVSTAL-LDHQLNPSDDEDKQ-----------EKALSQLYDAMPEGRSPL 396

  Fly   420 --IANK-------LAHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVHSKSQEELEKFRLQA 475
              :.||       .|||:.::...|||.|.....|.|:....|:::::...::|   |.||  :.
Zfish   397 DILKNKDERRRIGKAHLQRSIMGHEEAIRTHCRRRHLQKLDILSDILRASLNRS---LTKF--EQ 456

  Fly   476 SAKNIEDGD-LLERSVEASSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAPRCVRLQK 539
            :.|..|..| :|...:.:.::....:..|..|..||.|.|:||||:::|||::.|||||.:||
Zfish   457 NDKEDEFTDYMLAPDIISKTEKKAEMEIPAATKVKVTDLFQRLGPLSVFSAKQRWTAPRTIRL-- 519

  Fly   540 GSSLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINSLADLGGI 604
                            :..|.|                .||.::|||||.|..::....|..||:
Zfish   520 ----------------ILQDRD----------------LGFTLKGDAPVQIQSLDPLCPAAAGGL 552

  Fly   605 KEGDFIVEIAGVDVKWYSHQQVVQLIQSCGST-LELRVITPMDRNYLKPLSSKGSLSTLSAASSS 668
            ||||::|.:...|.||.....|::|::..... :.:||::.||       ||...::|.||....
Zfish   553 KEGDYLVAVGDTDCKWMGVSDVMKLLKDVDEEGINIRVVSMMD-------SSSQPMATKSATYCG 610

  Fly   669 GISSGF-------------PSPTSIAAKPK-----LHLKTSSS-------------SRPAGSVSS 702
            |:|..:             |....:|.||.     |..|.|||             :||:.:.|:
Zfish   611 GLSKTYSMICLAHDEDDKNPKSRKVAKKPSFLSFGLKNKKSSSTLSLPNADYSRPWNRPSANYSN 675

  Fly   703 S 703
            |
Zfish   676 S 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	53/83 (64%)
		BRO1_Rhophilin	122..514	CDD:185767	139/402 (35%)
		PDZ_canonical	578..642	CDD:483948	22/64 (34%)
rhpn2	NP_957472.1	HR1_Rhophilin-2	27..108	CDD:212024	52/80 (65%)
		BRO1_Rhophilin_2	112..496	CDD:185772	139/402 (35%)
		PDZ_rhophilin-like	514..591	CDD:467196	28/110 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	649..683		8/28 (29%)