DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rhp and Brox

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001020840.1	Gene:	Brox / 305031	RGDID:	1307161	Length:	411	Species:	Rattus norvegicus

Alignment Length:	333	Identity:	70/333 - (21%)
Similarity:	130/333 - (39%)	Gaps:	96/333 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 YIDAIADMTDTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSLTG-VPS 217
            :|:::.|.|   |.||                  |.|::.            |:|.|:|.| |||
  Rat    71 FINSVGDST---QESK------------------LRYIQN------------FKWTDTLQGHVPS 102

  Fly   218 CQRTIAFEKACTLFNLGGIYTQIGAR---HDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAPSM 279
            .|:...||.....||:...||:..:|   .:..||........|...|||:|:|:.:  ::.|.:
  Rat   103 AQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKE--SHIPKL 165

  Fly   280 --------DLKPQVLDVLVSLMLSQARECLFEK-LQLQ-----IEAMSHDCQAFRDLAGEAAQIS 330
                    ||:.:::|..:....::|:|....: ::|:     |.|::::..:|...|      .
  Rat   166 LTPAEKGRDLEARLIDAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYETASFYQKA------D 224

  Fly   331 HEYNEMHKNIQANDTHTYLPECWAGLVPVKAELYKAFAHFYKARSIDATDEL-KASKSSQKNQES 394
            |..:.:.....|.         |...:.:|...|.|:|:.|..:::.|:|:. :|.:|.|:.::.
  Rat   225 HTLSSLEPAHSAK---------WRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKL 280

  Fly   395 FIGNSQEVERITTADYGASDEASTSIANKLAHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKE 459
            :    .|.|.: ..:||.: :.....|....||                  |.:...||   :|.
  Rat   281 Y----AEAEAL-CKEYGET-KGPGPTAKPSGHL------------------FFRKLGSL---VKN 318

  Fly   460 VHSKSQEE 467
            ...|.|.|
  Rat   319 TLDKCQRE 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	70/333 (21%)
		PDZ_signaling	570..642	CDD:238492
Brox	NP_001020840.1	BRO1_Brox_like	4..356	CDD:185766	70/333 (21%)
Brox	NP_001020840.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..411
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910