Protein Alignment Rhp and Rhpn1

DIOPT Version :10

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: XP_006241962.1
• Gene: Rhpn1 / 300030
• RGDID: 1305688
• Length: 662
• Species: Rattus norvegicus
• Alignment Length: 680
• Identity: 247/680 - (36%)
• Similarity: 366/680 - (53%)
• Gaps: 72/680 - (10%)

  Fly    33 RGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRDTVALELSFVNSNLQLL 97
            :|.|........:|.:.|.:|:::|:||||:|.||||||:||||..:|:|||||||:||||||||
  Rat    27 KGHDSFVQNQPGQLHSHRARLHQQISKELRMRTGAENLYRATSNTWVRETVALELSYVNSNLQLL 91

  Fly    98 KEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIADMT 162
            ||:||||:.:.::.|.|..:..:||||||||||||:::..|..:.|.||:.|:.:.|...|.::.
  Rat    92 KEELAELSCNADVDQPEGESVTIPMIPLGLKETKELDWATPLKELISEHFGEDGASYETEIQELE 156

  Fly   163 DTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSLTGVPSCQRTIAFEKA 227
            |.|||::|||||.:|:.||..||:.|.:::.|||.|.|:.|:.|.|||||||||:.||.:||||.
  Rat   157 DLRQATRTPSRDEVGLDLLAAYYSQLCFLDARFFSPARSPGLLFHWYDSLTGVPAQQRALAFEKG 221

  Fly   228 CTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAPSMDLKPQVLDVLVSL 292
            ..|||:|.::||||||.|.:...|...|.::|.||||.||.:.:.|::|||.|:....|.:|..|
  Rat   222 SVLFNIGALHTQIGARQDCSCTEGTSQAAEAFQRAAGAFRLLRENFSHAPSPDMSAASLSMLEQL 286

  Fly   293 MLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPECWAGLV 357
            |::||:||:|..|.|:..|....|.....||.||.|::.||..:|:.:.......|||..|..|.
  Rat   287 MVAQAQECIFRGLLLRASATPDICPDQLQLAQEATQVATEYGLVHRAMAQPPVRDYLPASWTNLA 351

  Fly   358 PVKAELYKAFAHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERITTADYGASDEASTSIAN 422
            .||||.:.|.||::.|.::  .:...|:|.....||.....|     .|....|.:.........
  Rat   352 RVKAEHFCALAHYHAAMAL--CESTSAAKGELSRQEDIFQPS-----ATCEPQGPTLPQHPEERR 409

  Fly   423 KL--AHLKEALASIEEAQRLQRMCRFLKNKASLTEVM------KEVHSKSQEELEKFRLQASAKN 479
            ||  ||||.|:...|||.||..:|| :..|..|.:|:      :.:...|:.|.|....:|
  Rat   410 KLAKAHLKRAILGQEEALRLHTLCR-VPRKVDLLQVVVTQALRRSLTKYSELEREDDFFEA---- 469

  Fly   480 IEDGDLLERSVEASSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAPRCVRLQKGSSLY 544
            :|..|:..::.:|.     .::.|..:..||.|.|.||||:::||.:..|.....|.:.:|
  Rat   470 MEAPDIQPKTHQAP-----EVSIPSLSQVKVTDFFHRLGPLSVFSTKNRWQLVGPVHMTRG---- 525

  Fly   545 HSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINSLADLGGIKEGDF 609
                                :||          |||.:|||:||:||.|.....|:..|:||||:
  Rat   526 --------------------EGG----------FGFTLRGDSPVLIAAVVPGGQAESAGLKEGDY 560

  Fly   610 IVEIAGVDVKWYSHQQVVQLIQSCGST-LELRVITPMDRNYLKPLSSKGSLSTLSAASSSGISSG 673
            ||.:.|...||:.|.:||..::|.|.. :.|:|:     :.|.....:|:.....|...:....|
  Rat   561 IVSVNGQPCKWWKHVEVVTQLRSMGEEGVSLQVV-----SLLPGPEPRGTGPRRPALLWNQRECG 620

  Fly   674 FPSPTSIAAKP-------KLHLKTSSSSRP 696
            |.:||....:|       :.:.::.|.|.|
  Rat   621 FETPTPAHTRPWPILGWSRKNKQSKSGSHP 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	45/83 (54%)
		BRO1_Rhophilin	122..514	CDD:185767	149/399 (37%)
		PDZ_canonical	578..642	CDD:483948	28/64 (44%)
Rhpn1	XP_006241962.1	HR1	28..112	CDD:469609	45/83 (54%)
		BRO1_Rhophilin_1	116..499	CDD:185771	149/399 (37%)
		PDZ_rhophilin-like	519..594	CDD:467196	32/108 (30%)