DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rhp and SPAC17G6.05c

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_594252.1	Gene:	SPAC17G6.05c / 2542419	PomBaseID:	SPAC17G6.05c	Length:	775	Species:	Schizosaccharomyces pombe

Alignment Length:	440	Identity:	104/440 - (23%)
Similarity:	170/440 - (38%)	Gaps:	115/440 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 PMIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIADMTDTRQASKTPSRDA-------LGV 178
            |...|..||||..:::|||:.|:...|...        .|:.|..:|..|...:|       .|.
pombe     7 PFFYLNKKETKHSDWVEPFTTFVSRIYGNS--------VDVEDQIKAFNTLRENAADVDDTVAGK 63

  Fly   179 ALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSLTGVPSC----QRTIAFEKACTLFNLGGIYTQ 239
            .:|:.||..|.|:..||......:.:.|||.|.|.  |..    |.::|||||..||||..:.::
pombe    64 DILYSYYGQLDYLSFRFPTGGNGINISFEWSDILD--PDADFVKQSSLAFEKASVLFNLVSLLSR 126

  Fly   240 IGARHDRTTERGLDLAVDSFLRAA-------GVFRHIYDTFTNAPSMDLKPQVLDVLVSLMLSQA 297
            :.|.|...      ..||.:..||       |:.:.:.::|.:||..||....|..:.:|.|.||
pombe   127 MAANHASA------YTVDDYKAAANCLQCASGIAKLLRESFIHAPGRDLDSNFLLGIYNLFLGQA 185

  Fly   298 RECLFEKLQLQIEAMSHDCQAFRDLAGEAAQI----SHEYNEMHKNIQANDTHTYLPEC---WAG 355
            :||:...:.......:.:......:|..||.:    .|.:..|.            |.|   :..
pombe   186 QECVLGHMSFSASDSNMNYSLAAKIASSAATLYDSCVHAFESME------------PACNPNFIR 238

  Fly   356 LVPVKAELYKAFAHFYKARSIDATDELKASKSS-----QKNQESFIGNSQE-----------VER 404
            |...|....:.|:.::.||:     :|:.||..     .:..:|.:.::|:           :.:
pombe   239 LASAKKAALEGFSSYFMARA-----QLEKSKQGLAIGYLQQAKSILSSAQKLFNGIKLSTDFIHK 298

  Fly   405 ITTADYGASDEASTSIANKLAHLKEALASIEEAQRLQRMCRFLKNKASLTE-VMKEVHSKSQEEL 468
            .:.:||  ....||.|.:.|:||      ::.|::        .|.....: |:|||      ||
pombe   299 PSLSDY--PQTISTFIKSSLSHL------LKTAEK--------DNDFVFHDLVVKEV------EL 341

  Fly   469 EKFR-LQA-----------------SAKNIEDGDLLERSVEASSKFTLSL 500
            .|.. |||                 :||.|...||.:..|.::.....||
pombe   342 PKISPLQALPPLPLEKLYGSQDGFETAKKIVGDDLFKAFVPSAVTTASSL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	103/439 (23%)
		PDZ_signaling	570..642	CDD:238492
SPAC17G6.05c	NP_594252.1	BRO1_Alix_like	8..345	CDD:301330	92/391 (24%)
		V_ScBro1_like	382..745	CDD:185750	2/10 (20%)
		ALIX_LYPXL_bnd	439..748	CDD:290660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810