Protein Alignment Rhp and alx-1

DIOPT Version :10

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_001022713.1
• Gene: alx-1 / 176410
• WormBaseID: WBGene00007010
• Length: 882
• Species: Caenorhabditis elegans
• Alignment Length: 468
• Identity: 105/468 - (22%)
• Similarity: 189/468 - (40%)
• Gaps: 99/468 - (21%)

  Fly   127 LKETKEINFMEPFSDFILEHYS---EEPSMYIDAIADMTDTRQASKTPSRDALGVAL--LFRYYN 186
            ||.|.|::.::|.:.:|...|:   ...|...:|:.::...|..:.....|....||  |.|||:
 Worm    11 LKSTNEVDLVKPLTSYIDNVYNTSDNNRSDVAEAVQELNKLRSKACCQPLDKHQSALDVLTRYYD 75

  Fly   187 TLYYVERRFFPPDRNLGVYFEWYDSLT--GVPSCQRTI-----AFEKACTLFNLGGIYTQIGARH 244
            .|..:|.:.........|.|:|.|:..  .:.|.:.::     :||:|..|||:|.:.:||||..
 Worm    76 QLVAIENKIIISATQNPVVFKWKDAFDKGSLFSSRASLSLSDGSFERAAVLFNIGSLMSQIGAAQ 140

  Fly   245 DRTTERGLDLAVDSFLRAAGVFRHIYDT----FTNAPSMDLKPQVLDVLVSLMLSQARECLFEKL 305
            ...|:..:.::...|.::||||..:.|.    ....|:.||.|..|..|.:||.:||:|.::.|
 Worm   141 QFHTDDEIKVSAKLFQQSAGVFARLRDVVLGMVQQEPTPDLMPDTLAALSALMTAQAQEAIYIK- 204

  Fly   306 QLQIEAMSH-DCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPECWAGLVPVKAELYKAFAH 369
                   .| |......:...:||::..|:|..|.:..:.......:.|:.:|..|...|:|.|.
 Worm   205 -------GHKDKMKATSMVKISAQVAEFYSEAQKMMSKDIVRGLWDKDWSAIVSGKNLAYQALAQ 262

  Fly   370 FYKARSIDATDELKASKSSQKNQESFIGNSQEVERITTADYGASDEASTSIANKLAHLKEALASI 434
            ::                    |....|.:::                  |..:|:.|.|:|...
 Worm   263 YH--------------------QSEVCGEARQ------------------IGEQLSRLAESLKLF 289

  Fly   435 EEAQR-LQRMCRFLKNKASLTEVMKEVHSKSQEELEKFRLQASAKNIEDGDLLE-------RSVE 491
            :.||: |.|         .:|.:.....|.|       :..|:||  :|.|.:.       |::.
 Worm   290 DTAQKYLPR---------DITGIWDIYPSVS-------KAHAAAK--KDNDFIYHEKVSDFRTLP 336

  Fly   492 ASSKFTLSLTGPDFT--SHKVKDPFKRLGPIAIFSARRHWTAPRC-------VRLQKGSSLYHSV 547
            ...|..|:...|..|  :...:|.|..|.|:.:.:|.:.:.|.:.       ||:::.:.|.:.|
 Worm   337 TLPKAVLAKPTPMQTPMTPSFRDMFAVLVPVQVHNAMQSYDARKAELVNMETVRMREATQLMNGV 401

  Fly   548 PSNDNKCPLDNDD 560
            .::.| .|...||
 Worm   402 LASLN-LPAALDD 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	92/413 (22%)
		PDZ_canonical	578..642	CDD:483948
alx-1	NP_001022713.1	BRO1_Alix	4..351	CDD:185763	90/403 (22%)
		V_Alix	366..704	CDD:185748	11/49 (22%)