DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rhp and BROX

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_006711236.1	Gene:	BROX / 148362	HGNCID:	26512	Length:	428	Species:	Homo sapiens

Alignment Length:	418	Identity:	82/418 - (19%)
Similarity:	157/418 - (37%)	Gaps:	103/418 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 MEPFSDFILEHYSEEPSMYIDA-----------IADMTDTRQASKTPSRDALGVALLFRYYNTLY 189
            :|.|:|.     |..|.|..:|           |..:.::.|.||                  |.
Human    61 LELFTDL-----SCNPEMMKNAADSYFSLLQGFINSLDESTQESK------------------LR 102

  Fly   190 YVERRFFPPDRNLGVYFEWYDSLTG-VPSCQRTIAFEKACTLFNLGGIYTQIGAR---HDRTTER 250
            |::.            |:|.|:|.| |||.|:...||.....||:...||:..:|   .:..||.
Human   103 YIQN------------FKWTDTLQGQVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITED 155

  Fly   251 GLDLAVDSFLRAAGVFRHIYDTFTNAPSM--------DLKPQVLDVLVSLMLSQARECLFEK-LQ 306
            .......|...|||:|:|:.:  ::.|.:        ||:.::::..|....::|:|....: ::
Human   156 EAKEVHRSLKIAAGIFKHLKE--SHLPKLITPAEKGRDLESRLIEAYVIQCQAEAQEVTIARAIE 218

  Fly   307 LQ-----IEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPECWAGLVPVKAELYKA 366
            |:     |.|::::...|...|      .|..:.:.....|.         |...:.:|...|.|
Human   219 LKHAPGLIAALAYETANFYQKA------DHTLSSLEPAYSAK---------WRKYLHLKMCFYTA 268

  Fly   367 FAHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERITTADYGASDEASTSIA-------NKL 424
            :|:.|...::.|:|:...:..|.:..|.....::.:    ..:||.:.....::.       .||
Human   269 YAYCYHGETLLASDKCGEAIRSLQEAEKLYAKAEAL----CKEYGETKGPGPTVKPSGHLFFRKL 329

  Fly   425 AHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVHSKSQE----ELEKFRLQASAKNIEDGDL 485
            .:|.:  .::|:.||......|.|......::..:.:....|    |.....:|.:.:.:...||
Human   330 GNLVK--NTLEKCQRENGFIYFQKIPTEAPQLELKANYGLVEPIPFEFPPTSVQWTPETLAAFDL 392

  Fly   486 LERSVEASSKFTLSLTGPDFTSHKVKDP 513
            .:|..:.|:|     ..|:.....||:|
Human   393 TKRPKDDSTK-----PKPEEEVKPVKEP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	82/418 (20%)
		PDZ_signaling	570..642	CDD:238492
BROX	XP_006711236.1	BRO1_Brox_like	21..373	CDD:185766	71/369 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910