DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rhp and Rhpn1

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_006520510.1	Gene:	Rhpn1 / 14787	MGIID:	1098783	Length:	662	Species:	Mus musculus

Alignment Length:	673	Identity:	249/673 - (36%)
Similarity:	365/673 - (54%)	Gaps:	68/673 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EDDEKLNELSFCFVRGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRDTV 83
            :||..:.:....||:...       .:||:.|.:|:::|:||||:|.||||||:||||..:|:||
Mouse    20 QDDGSIRKGYGSFVQNQP-------GQLQSHRARLHQQISKELRMRTGAENLYRATSNTWVRETV 77

  Fly    84 ALELSFVNSNLQLLKEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEHYS 148
            |||||:||||||||||:||||::||::.|.|.....:||||||||||||:::..|..:.|.||:.
Mouse    78 ALELSYVNSNLQLLKEELAELSTSVDVDQPEGEGITIPMIPLGLKETKELDWATPLKELISEHFG 142

  Fly   149 EEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSLT 213
            |:.:.:...|.::.|.|||::|||||..|:.||..||:.|.:::.|||.|.|:.|:.|.||||||
Mouse   143 EDGTSFETEIQELEDLRQATRTPSRDEAGLDLLAAYYSQLCFLDARFFSPSRSPGLLFHWYDSLT 207

  Fly   214 GVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAPS 278
            |||:.||.:||||...|||:|.::||||||.|.:...|.:.|.::|.||||.||.:.:.|::|||
Mouse   208 GVPAQQRALAFEKGSVLFNIGALHTQIGARQDCSCTEGTNHAAEAFQRAAGAFRLLRENFSHAPS 272

  Fly   279 MDLKPQVLDVLVSLMLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQAN 343
            .|:....|.:|..||::||:||:|:.|.|...|....|.....||.||||::.||..:|:.:...
Mouse   273 PDMSAASLSMLEQLMIAQAQECIFKGLLLPASATPDICPDQLQLAQEAAQVATEYGLVHRAMAQP 337

  Fly   344 DTHTYLPECWAGLVPVKAELYKAFAHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERITTA 408
            ....|||..|..|..||||.:.|.||::.|.::  .:...|:|.....||.....|...|.:
Mouse   338 PVRDYLPASWTNLAHVKAEHFCALAHYHAAMAL--CESHPAAKGELARQEHVFQPSTPHEPL--- 397

  Fly   409 DYGASDEASTSIANKL--AHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVHSKSQEELEKF 471
              |.:.........||  ||||.|:...|||.||..:||.|: |..|.:|:  |....:..|.|:
Mouse   398 --GPTLPQHPEDRRKLAKAHLKRAILGQEEALRLHTLCRVLR-KVDLLQVV--VTQALRRSLAKY 457

  Fly   472 RLQASAKNIEDGDLLERS----VEASSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAP 532
                |....|| |..|.:    ::..:..|..:..|..:..||.|.|.||||:::||.:..|...
Mouse   458 ----SQLERED-DFFEATEAPDIQPKTHQTPEVRMPSLSQVKVTDFFHRLGPLSVFSTKNRWQLV 517

  Fly   533 RCVRLQKGSSLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINS 597
            ..|.:.:|..                                  :|||.:|||:||:||.|....
Mouse   518 GPVHMTRGEG----------------------------------SFGFTLRGDSPVLIAAVVPGG 548

  Fly   598 LADLGGIKEGDFIVEIAGVDVKWYSHQQVVQLIQSCGST-LELRVITPMDRNYLKPLSSKGSLST 661
            .|:..|:||||:||.:.|...||:.|.:||..::|.|.. :.|:|:     :.|.....:|:...
Mouse   549 QAESAGLKEGDYIVSVNGQPCKWWKHLEVVTQLRSMGEEGVSLQVV-----SLLPSPEPRGTGPR 608

  Fly   662 LSAASSSGISSGFPSPTSIAAKP 684
            .:|...:....||.:|.....:|
Mouse   609 RAALLWNQRECGFETPMPTRTRP 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	46/83 (55%)
		BRO1_Rhophilin	122..514	CDD:185767	152/397 (38%)
		PDZ_signaling	570..642	CDD:238492	28/72 (39%)
Rhpn1	XP_006520510.1	HR1_Rhophilin-1	28..112	CDD:212023	48/90 (53%)
		BRO1_Rhophilin_1	116..499	CDD:185771	152/397 (38%)
		PDZ_signaling	520..594	CDD:238492	30/107 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834489
Domainoid	1	1.000	88	1.000	Domainoid score	I7938
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1791
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49710
OrthoDB	1	1.010	-	-		D286986at33208
OrthoFinder	1	1.000	-	-		FOG0003216
OrthoInspector	1	1.000	-	-		otm44287
orthoMCL	1	0.900	-	-		OOG6_105514
Panther	1	1.100	-	-	LDO	PTHR23031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5869
SonicParanoid	1	1.000	-	-		X1868
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800