DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rhp and rhpn1

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	XP_003200825.2	Gene:	rhpn1 / 100537370	ZFINID:	ZDB-GENE-081031-79	Length:	659	Species:	Danio rerio

Alignment Length:	703	Identity:	274/703 - (38%)
Similarity:	390/703 - (55%)	Gaps:	105/703 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRDTVALELSFVNSNLQLL 97
            :|.||..:|.|||||.||.|||::||:||.||:||||||:|::|:|:::||||||||||||||||
Zfish    23 KGCDPLVSTQRSKLQQRRAKLNQQINRELLLRSGAENLYRASTNQKVKETVALELSFVNSNLQLL 87

  Fly    98 KEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIADMT 162
            ||:|.|||||:.|||:||....:|||||||||||||:...|..|||.|||.|:.|:|::.|.|..
Zfish    88 KEELEELNSSMNIYQTESETLNVPMIPLGLKETKEIDMTVPLQDFIAEHYGEDASLYLNEIQDFM 152

  Fly   163 DTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSLTGVPSCQRTIAFEKA 227
            :.|||.:||||:..|..||..|:|.||::::|||.|.|:|||:|.||||||||||.||.:||||.
Zfish   153 ELRQAMRTPSRNEAGQELLMEYFNQLYFLDQRFFSPHRSLGVHFHWYDSLTGVPSVQRALAFEKG 217

  Fly   228 CTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAPSMDLKPQVLDVLVSL 292
            ..|||:|.:|||||||.||:|..|::.|:|:|.||||.|.::.:.|::|||:|:....|.:||.|
Zfish   218 SVLFNIGALYTQIGARQDRSTLSGIEDAIDAFQRAAGAFLYLQENFSHAPSLDMSGSALSMLVRL 282

  Fly   293 MLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYLPECWAGLV 357
            |::|.:||:.||:.|.|:.:  ........|.|||::|..|:.:.:.:.......|:|..|..:|
Zfish   283 MVAQVQECVCEKVLLNIQDI--HLNVLLQAAQEAARVSDVYSLVLQAMSVPLLKDYVPFSWISMV 345

  Fly   358 PVKAELYKAFAHFYKARSI-DATDELKASKSSQKNQESFIGNSQEVERITTADYGASDEASTSIA 421
            .||...::|.||:|.|.:: |.               |.:|:..|    ..|:..|..:..|...
Zfish   346 QVKTHHFRALAHYYTAVALCDC---------------SGVGDEDE----DGAEIKALVQIHTRQP 391

  Fly   422 NKL-------------AHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVHSKSQEELEKFRL 473
            .||             |||::|:...|||.||..:|:.|:....|.||:.:.|::|   |||:
Zfish   392 EKLNLQDPEDKRRLGKAHLRKAIIRHEEALRLHGVCKMLRKMDILQEVLSDAHTRS---LEKY-- 451

  Fly   474 QASAKNIEDGDLLE----RSVEASSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAPRC 534
              |..:.|| |..|    ..|::.::....:..|||:..:|.|.|.||||:::||||..||. |.
Zfish   452 --SDIDQED-DFCEVAEAPEVQSHTQQKPDIKAPDFSVVRVTDIFHRLGPLSVFSARNRWTR-RH 512

  Fly   535 VRLQKGSSLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINSLA 599
            |.|.:|.:                                  ..|..:|||:||::|.|.....|
Zfish   513 VCLVRGEA----------------------------------GLGLTLRGDSPVLVAGVLPGGCA 543

  Fly   600 DLGGIKEGDFIVEIAGVDVKWYSHQQVVQLIQSCGST-LELRVITPMDRNYLKPLSSKGSLSTLS 663
            ..||::|||:||.:..||.:|..|.:||..::||... |||.:||.......:.::       ||
Zfish   544 AEGGLREGDYIVAVNSVDCRWAEHAEVVHALKSCPDRGLELDIITLQTHEVERRMN-------LS 601

  Fly   664 AASSSGISSGFPSPTSIAAKPKLHLKTSSSSRPAGSVSSSSWNPFRRTPSLAK 716
            .:......||               ....:.|..|..|||.|....|...::|
Zfish   602 PSGEQDYQSG---------------SQRRAGREYGGSSSSVWGWSWRNSGVSK 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	58/83 (70%)
		BRO1_Rhophilin	122..514	CDD:185767	159/409 (39%)
		PDZ_signaling	570..642	CDD:238492	27/72 (38%)
rhpn1	XP_003200825.2	HR1	24..107	CDD:294066	58/82 (71%)
		BRO1_Alix_like	112..493	CDD:301330	159/409 (39%)
		PDZ_signaling	511..580	CDD:238492	28/102 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577424
Domainoid	1	1.000	291	1.000	Domainoid score	I1495
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1629
OMA	1	1.010	-	-		QHG49710
OrthoDB	1	1.010	-	-		D286986at33208
OrthoFinder	1	1.000	-	-		FOG0003216
OrthoInspector	1	1.000	-	-		otm25894
orthoMCL	1	0.900	-	-		OOG6_105514
Panther	1	1.100	-	-	LDO	PTHR23031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1868
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770