DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rhp and rhpn2

DIOPT Version :9

Sequence 1:	NP_511168.3	Gene:	Rhp / 32531	FlyBaseID:	FBgn0026374	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001120536.1	Gene:	rhpn2 / 100145690	XenbaseID:	XB-GENE-966649	Length:	682	Species:	Xenopus tropicalis

Alignment Length:	701	Identity:	255/701 - (36%)
Similarity:	389/701 - (55%)	Gaps:	62/701 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NEDDEKLNELSFCFVRGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRDT 82
            |.:.::|:|.:: |.:|.. .|.|.||||||:|..||::|.|.:|:|||||||.:||:|.|:|:.
Frog     9 NLNGKRLSEQNY-FRKGKS-IAQTGRSKLQNQRASLNQQILKAMRMRAGAENLLRATANNKIREQ 71

  Fly    83 VALELSFVNSNLQLLKEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEHY 147
            |.|||||||||||.|||:|..||.|||:||.......:|:|||||||||:::|...|.|||||||
Frog    72 VLLELSFVNSNLQRLKEELERLNISVEVYQHTEQASNIPLIPLGLKETKDVDFTTAFKDFILEHY 136

  Fly   148 SEEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSL 212
            ||:.|.|.:.:||:.|.|||.:|||||..|:.||..|:..|.::|.|||||.||:|:.|.||||.
Frog   137 SEDASEYENELADLMDLRQACRTPSRDEAGIELLMSYFQQLGFLENRFFPPSRNMGILFTWYDSF 201

  Fly   213 TGVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAP 277
            ||||..|..|:.|||..|||:..:|||||.|.:|.|:.||:.:|.:|.:||||..::.:|||:.|
Frog   202 TGVPVSQPNISLEKASILFNIAALYTQIGTRCNRQTKIGLEESVTTFQKAAGVLNYLKETFTHTP 266

  Fly   278 SMDLKPQVLDVLVSLMLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQA 342
            |.|:.|.:|.:|:.::|::|.||.|||:.|  ..:.::......:|.|||::|..:.:::..:..
Frog   267 SYDMSPAMLGMLIKMLLAEAHECYFEKMIL--SGIQNEFCTLLKVAQEAAKVSEVHMQVYTLMNQ 329

  Fly   343 NDTHTYLPECWAGLVPVKAELYKAFAHFYKARSIDATD-ELKASKSSQKNQESFIGNSQEVERIT 406
            ......:|..|:.:|.||||.|||..:::.|  :...| :|..|....|.:::.......:....
Frog   330 APIKENVPYSWSVMVQVKAEHYKALTNYFVA--VILIDYQLNLSDDEDKQEKAIAQLYDSMPEGL 392

  Fly   407 TADYGASDEASTSIANKLAHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVHSKSQEELEKF 471
            ||.....|:...::..| |||.:|:...|||.|...:|..|:....|..::...|.:|   |.||
Frog   393 TAQTILKDQQQRTLLGK-AHLSKAIRCHEEAIRFSTLCSTLRQIDVLQNILSAFHQRS---LLKF 453

  Fly   472 RLQASAKNIEDGDLLER-SVEASSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAPRCV 535
              ....|:.:..|||.. .:.:.:::...:..|..:..|..|.|:||||:::||.::.|:|||.|
Frog   454 --SQHQKHDDFLDLLSAPDIVSKTEYQAEMIPPQLSRVKATDLFQRLGPLSVFSVKQRWSAPRKV 516

  Fly   536 RLQKGSSLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINSLAD 600
            .:.|                        .||          :|||.::.|:||.:..::....:.
Frog   517 CITK------------------------EDG----------DFGFLLKCDSPVQVVSLDPLCPSA 547

  Fly   601 LGGIKEGDFIVEIAGVDVKWYSHQQVVQLIQSCG-STLELRVITPMDRNYLKPLSSKGSLSTLSA 664
            ..|:||||:||.:.|.|.||.|..||:.::...| .::|::||:..|:.        .||...||
Frog   548 TEGLKEGDYIVSVEGEDCKWCSTSQVMDMLHGTGEESIEIQVISIQDQT--------NSLHNKSA 604

  Fly   665 ASSSGISSGFPSPTSIAAKPKLHLKTSSSSRPAGSVSSSSWNPFRRTPSLA 715
            ...:|:...: |...:|.....|.||..:::   .:|..||. ||.....|
Frog   605 TYYAGMQKTY-SLVCLAMDNDKHTKTQKATK---KLSFLSWG-FRNRQKAA 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	50/83 (60%)
		BRO1_Rhophilin	122..514	CDD:185767	144/393 (37%)
		PDZ_signaling	570..642	CDD:238492	22/72 (31%)
rhpn2	NP_001120536.1	HR1	26..107	CDD:294066	49/81 (60%)
		BRO1_Rhophilin_2	111..495	CDD:185772	144/393 (37%)
		PDZ_signaling	513..590	CDD:238492	28/110 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1563
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H12407
Inparanoid	1	1.050	450	1.000	Inparanoid score	I1577
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286986at33208
OrthoFinder	1	1.000	-	-		FOG0003216
OrthoInspector	1	1.000	-	-		otm49461
Panther	1	1.100	-	-	O	PTHR23031
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5869
SonicParanoid	1	1.000	-	-		X1868
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190