DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Paf-AHalpha and megf8

DIOPT Version :9

Sequence 1:	NP_525089.2	Gene:	Paf-AHalpha / 32529	FlyBaseID:	FBgn0025809	Length:	225	Species:	Drosophila melanogaster
Sequence 2:	XP_005158088.1	Gene:	megf8 / 791154	ZFINID:	ZDB-GENE-090730-1	Length:	2870	Species:	Danio rerio

Alignment Length:	194	Identity:	42/194 - (21%)
Similarity:	64/194 - (32%)	Gaps:	61/194 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SDCRE-KDPDVIFLGDCIFETVQDTE-AWNKYFAPLHCLNFSIRDDCTEHVLW-----RIENGAL 85
            |||.. .|.|.:     ::||:.||: :.||....|..:..|:... .:..||     .:..|.|
Zfish  1487 SDCSSISDTDSL-----VWETLLDTQLSVNKAHRFLRRMGHSLMSS-PQGTLWMYGGLSLSEGIL 1545

  Fly    86 DNVNPKIVVLHVGTNNVRNSAEEVAEGVLANVTKIRQKLPNAYIVLPSLLPRGQQPNKL------ 144
            .||....|.....|..:.:|.||             ..:|         |||....:.|
Zfish  1546 GNVYRYSVADRRWTEVLTSSVEE-------------SSMP---------LPRYHHASALVYYQFP 1588

  Fly   145 ----REKNAKINEVVNGLTKGLYRVQTVAIDKGLVQTDGSISHHDMFDYKNLTNAGAKKILEPL 204
                ......:..||.|:||     :.||.|...:..|.    .:...||:       .:|.|:
Zfish  1589 ISGSHSATRNLMFVVGGVTK-----EGVANDTWCLNLDS----QEWKQYKS-------SVLPPV 1636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Paf-AHalpha	NP_525089.2	PAF_acetylesterase_like	3..212	CDD:238858	42/194 (22%)
megf8	XP_005158088.1	CUB	36..134	CDD:238001
		PLN02153	211..>458	CDD:177814
		Kelch_3	240..283	CDD:290151
		Kelch_6	276..319	CDD:290672
		KELCH repeat	277..326	CDD:276965
		KELCH repeat	329..372	CDD:276965
		Kelch_6	330..372	CDD:290672
		KELCH repeat	380..429	CDD:276965
		KELCH repeat	439..487	CDD:276965
		PSI	931..982	CDD:279745
		EGF_3	1088..1122	CDD:289699
		Laminin_EGF	1169..1214	CDD:278482
		EGF_Lam	1216..1265	CDD:238012
		CUB	<1307..1413	CDD:294042
		Kelch_4	1518..1561	CDD:290154	9/43 (21%)
		KELCH repeat	1575..1633	CDD:276965	13/73 (18%)
		Kelch_3	1597..1643	CDD:290151	13/56 (23%)
		KELCH repeat	1636..1676	CDD:276965	0/1 (0%)
		Kelch_3	1646..1696	CDD:290151
		KELCH repeat	1689..1737	CDD:276965
		KELCH repeat	1745..1791	CDD:276965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1388
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900