DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Paf-AHalpha and PAFAH1B2

DIOPT Version :9

Sequence 1:	NP_525089.2	Gene:	Paf-AHalpha / 32529	FlyBaseID:	FBgn0025809	Length:	225	Species:	Drosophila melanogaster
Sequence 2:	XP_016873329.1	Gene:	PAFAH1B2 / 5049	HGNCID:	8575	Length:	242	Species:	Homo sapiens

Alignment Length:	221	Identity:	106/221 - (47%)
Similarity:	148/221 - (66%)	Gaps:	0/221 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NPCVLPTPLPDLDGDKRWHSIHRRFISDCREKDPDVIFLGDCIFETVQDTEAWNKYFAPLHCLNF 66
            ||..:|....|:.||.||.|.|.||:.||::|:|||:|:||.:.:.:|..|.|.:.|:|||.|||
Human    20 NPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWRELFSPLHALNF 84

  Fly    67 SIRDDCTEHVLWRIENGALDNVNPKIVVLHVGTNNVRNSAEEVAEGVLANVTKIRQKLPNAYIVL 131
            .|..|.|.|||||::||.|:|:.||::|:.|||||..|:|||||.|:.|.|..|..:.|.|.|::
Human    85 GIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIV 149

  Fly   132 PSLLPRGQQPNKLREKNAKINEVVNGLTKGLYRVQTVAIDKGLVQTDGSISHHDMFDYKNLTNAG 196
            ..|||||::||.||:||||:|:::......|..||.:..|.|.|.:||:||.|||||:.:||..|
Human   150 LGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGG 214

  Fly   197 AKKILEPLYDLLSQILNENEPENDLT 222
            ..||.:||::|:.|:|.|...|...|
Human   215 YAKICKPLHELIMQLLEETPEEKQTT 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Paf-AHalpha	NP_525089.2	PAF_acetylesterase_like	3..212	CDD:238858	101/208 (49%)
PAFAH1B2	XP_016873329.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154952
Domainoid	1	1.000	143	1.000	Domainoid score	I4659
eggNOG	1	0.900	-	-		E1_KOG1388
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1932
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3467
Isobase	1	0.950	-	0	Normalized mean entropy	S5447
OMA	1	1.010	-	-		QHG48396
OrthoDB	1	1.010	-	-		D1604899at2759
OrthoFinder	1	1.000	-	-		FOG0004246
OrthoInspector	1	1.000	-	-		otm40972
orthoMCL	1	0.900	-	-		OOG6_104898
Panther	1	1.100	-	-	LDO	PTHR11852
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4710
SonicParanoid	1	1.000	-	-		X2985
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750