DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Paf-AHalpha and ICE1

DIOPT Version :9

Sequence 1:	NP_525089.2	Gene:	Paf-AHalpha / 32529	FlyBaseID:	FBgn0025809	Length:	225	Species:	Drosophila melanogaster
Sequence 2:	NP_056140.1	Gene:	ICE1 / 23379	HGNCID:	29154	Length:	2266	Species:	Homo sapiens

Alignment Length:	226	Identity:	44/226 - (19%)
Similarity:	81/226 - (35%)	Gaps:	68/226 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DCIFETVQDTEAWNKYFA--PLHCLNFSIRDDCTEHVLWRIENGALDNVN-----PKIVVLHVGT 99
            ||    ..||:...|.|:  |.|          :||   :::...|:.::     |:   ..:|.
Human   652 DC----GNDTDITTKVFSTEPHH----------SEH---KLQTKTLNTLHLQSEPPE---CSIGG 696

  Fly   100 NNVRNSA-------------EEVAEGVLANVTKIRQKLPNAYIVLPSLLPRGQQPNKLREKNAKI 151
            ||:.||.             ::.:.|:  ..||:.:.|...:.:..|:..:..:..:...::.:|
Human   697 NNLENSLCALSPELGASNFNDQKSSGI--EYTKVVKGLTKIHSLPRSVFMKATKDGQCESQDPRI 759

  Fly   152 NEVVN--GLTKGLYRVQTVAIDKGLVQTDGSISHH-DMF------------DYKNLTNAGAKKIL 201
            ...:|  ..| .|...|...|..||.....:..|| |:.            :::..|:...:|.:
Human   760 ELTLNKPDFT-SLIGSQAALIKSGLGFVKSTSWHHSDLLRKGGEESLRAKSEHEQKTSHQLQKAM 823

  Fly   202 --------EPLYDLLSQILNENEPENDLTPS 224
                    .|..|||.:  |.|..|...|.|
Human   824 PFLQNRGPTPKPDLLRE--NNNPVEFKTTAS 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Paf-AHalpha	NP_525089.2	PAF_acetylesterase_like	3..212	CDD:238858	39/212 (18%)
ICE1	NP_056140.1	DUF2031	<27..>181	CDD:299055
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..259
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..540
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	591..623
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..955
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	977..1001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1107..1133
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1295..1372
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1467..1510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1543..1707
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1809..1902
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154953
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930