Protein Alignment Efhc1.1 and EFHC2

DIOPT Version :10

• Sequence 1: NP_573075.1
• Gene: Efhc1.1 / 32528
• FlyBaseID: FBgn0030691
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_079460.2
• Gene: EFHC2 / 80258
• HGNCID: 26233
• Length: 749
• Species: Homo sapiens
• Alignment Length: 763
• Identity: 252/763 - (33%)
• Similarity: 409/763 - (53%)
• Gaps: 46/763 - (6%)

  Fly     7 MPLLPGTLF-RDVSKGHYPKPQSLANVQGLSMLSDRQQPAPVESGSVTVDISCPPVGASSIYPPR 70
            :|||||..| |:|.|..:.|.|.......:.||...::|.  ..|...:.....|  ..||||..
Human     3 LPLLPGNSFNRNVGKEKFHKSQHWGFCNNVMMLVSDEKPG--IGGEPLLGQKIKP--KCSIYPKG 63

  Fly    71 SGPRMPPWLAYDKKVLCFHAYFKQTLQEVYHAPYLVRKVKIYYYLEDGTLEIYEPRVDNSGIVQG 135
            .|..:|.|:|:||:||.|.||.::.:.:.....|.:|..|||:|.||.|:::.||.|.|||::||
Human    64 DGSDVPSWVAFDKQVLSFDAYLEEEVLDKSQTNYRIRYYKIYFYPEDDTIQVNEPEVKNSGLLQG 128

  Fly   136 CVVHRQRVQKAPPCDNEFMSLIDLNVDQTVQIFDRQYHITDCDPFTRTFLNKRGITVPDPVKSPC 200
            ..:.|.|:...||.:::|.::...||...|..:.|.:.|.|||.|||.||.|.|:.|..||:.|.
Human   129 TSIRRHRITLPPPDEDQFYTVYHFNVGTEVVFYGRTFKIYDCDAFTRNFLRKIGVKVNPPVQCPE 193

  Fly   201 DPTEEQRKRENQPRSGNLIPKN--HPFAQFLKYDRQILKFQAYWDDRTE-FGDVRKLELCYYLSD 262
            ||..:.| ||.......|.|..  ....|||:|..:||.|...|||... |||.|:|.|.|:|.|
Human   194 DPYMKIR-REVVEHVEPLRPYESLDTLKQFLQYHGKILCFFCLWDDSVSMFGDRRELILHYFLCD 257

  Fly   263 DTIEIKEQHIRNSGRDGPTVFLKRGRLAREF-EGLQLPGQMTPMTLLNVLGTNMRNVR--YCVDP 324
            |||||||....:||||...:||:|.:|.:.. ..:..|||:|...:||..|..::|..  |..|.
Human   258 DTIEIKELLPHSSGRDALKMFLRRSKLPKNCPPRVYQPGQITDRAVLNSYGDFIKNQADGYLFDR 322

  Fly   325 LNTGNKEIHYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRYGIQDFT------PLPIPAR 383
            ...|..:..:|::.||.:|..|||:||.|::.:.|.||::||:.:|||::||      |.|.|
Human   323 YKLGKVDQEFYKDSDLSLGVTINVWGRKVLLYDCDEFTKSYYKSKYGIENFTSVSCKPPSPPP-- 385

  Fly   384 SDDCADHRSERQLPPYNGWGSYEDSVGNCISVEPKPPKSDFKKFIKYDRY-----VLRFGAKMLS 443
                   :.||:.|||||:||.|||:.|||.::|.|.:.:||||::.|.|     :|||.||:::
Human   386 -------KIERKFPPYNGFGSEEDSLRNCIDLKPTPHRRNFKKFMEKDSYGSKSNILRFFAKLVT 443

  Fly   444 TIKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERFSCKQPQYYMPWNF 508
            ....:.:|:|||||||.|||:.:.|...||||..||.|:||:|::.||||.|..:..:|......
Human   444 DKCVDLDRMFVISYYLGDDTISVFEPIERNSGIAGGMFLKRSRVKKPGQEVFKSELSEYIKAEEL 508

  Fly   509 FVGSTMSLKDFIFHIVSADEYTLMYMEHHPEIFPHANVGVIMEKVKSAL-QNRMAEFVGSCVPDC 572
            ::|.|:::..::|.:::||||||.|||.:.:.:|.:|:.:.::|:|... ::|..:.|....
Human   509 YIGVTVNVNGYLFRLLNADEYTLNYMEQNTDKYPFSNLKLALQKLKQEEGKSRELKQVFKAA--- 570

  Fly   573 TDLEKKRDVFVSFESFKGALISIMGNQISDHEIISLCRHFSAEKSQPNACDRSTVRAAAHLELKR 637
               :.|....|.:.:|:..|:|:....:::.|.:::.||:...:.  ...|...:.|.||.:.|:
Human   571 ---DSKHTNMVDYNTFRDILMSLTVGNLAEQEFVTIARHYRVPEG--TCSDMDFLIALAHEKFKK 630

  Fly   638 TLWNARDDLMEHFHHINPTNQPFLPEVKVRSALRGCRLPFSLELIDNILSILNRNECDDIEVCDL 702
            .::...|..:....:.:...:..||...::...:..|||.|.:|::::||....:| ..|:....
Human   631 NMFENFDTFIYSCVYEDREKKNVLPTKDIKRLCKSSRLPLSDDLLESLLSRFEDSE-KQIDYKSF 694

  Fly   703 MNFIDVSCGKGCDMLPVNHAFELCPKI----PFLNKGRVVNFTCFLRE 746
            .:.::.......::.|.::..|.|..:    |.....:.:::..||::
Human   695 FSALNWRKNPVPELQPASYLKERCEDVWLGMPSPIPAKYIDYWTFLKD 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.1	NP_573075.1	DM10	82..189	CDD:128921	43/106 (41%)
		DM10	232..370	CDD:128921	56/141 (40%)
		DM10_dom	424..530	CDD:461948	45/110 (41%)
EFHC2	NP_079460.2	DM10	75..182	CDD:128921	43/106 (41%)
		DM10	226..368	CDD:128921	56/141 (40%)
		DM10_dom	419..530	CDD:461948	45/110 (41%)