DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Efhc1.1 and Efhc1

DIOPT Version :9

Sequence 1:	NP_573075.1	Gene:	Efhc1.1 / 32528	FlyBaseID:	FBgn0030691	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_082250.1	Gene:	Efhc1 / 71877	MGIID:	1919127	Length:	648	Species:	Mus musculus

Alignment Length:	650	Identity:	206/650 - (31%)
Similarity:	322/650 - (49%)	Gaps:	76/650 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IPGMPLLPGTLFRDVSKGHYPKPQSLANVQGLSML--------SDRQQPAPVESGSVTVDISCPP 60
            :.|:|.|||:.|.|.:|..:.:.|:|....|.:::        .||.....:....:....:..|
Mouse     6 VHGLPFLPGSSFTDSTKTAFHRSQTLNYRNGYAVVRRPTMGIGGDRLHYNQLSQAELDELANKAP 70

  Fly    61 VGASSIYPPRSGPR---MPPWLAYDKKVLCFHAYFKQTLQEVYHAPYLVRKVKIYYYLEDGTLEI 122
            :  .:..|.:..|.   :|..:|:|||||.|.|||::.:.......|.:|.|.|||||||.::.:
Mouse    71 I--LTYGPLKQAPLAEFVPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRHVNIYYYLEDDSMSV 133

  Fly   123 YEPRVDNSGIVQGCVVHRQRVQKAPPCDNEFMSLIDLNVDQTVQIFDRQYHITDCDPFTRTFLNK 187
            .||.|:||||.||.::.|||..|....|:....  |||....:.::.:.:.|.|||.||:.||..
Mouse   134 IEPVVENSGIPQGKLIKRQRFTKNDMGDHYHWK--DLNRGINLTVYGKTFRIVDCDRFTQDFLES 196

  Fly   188 RGITVPDPVKSPCDPTEEQRKRENQPRSGNLIPKN-HPFAQFLKYDRQILKFQAYWDDRTE-FGD 250
            :||.:....|.|.||..:.||   :|....:.|.: ....|||.:|:|:|:|.|.|||... ||:
Mouse   197 QGIELNPSEKIPLDPYTQLRK---EPVRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDSLFGE 258

  Fly   251 VRKLELCYYLSDDTIEIKEQHIRNSGRDGPTVFLKRGRLAREFEGLQLPGQMTPMTLLNVLGTNM 315
            .|...:.|||.|||:||:|.|.||:|||...:.:.|.|:.:                  ||..|.
Mouse   259 CRHYIIHYYLMDDTVEIREVHERNNGRDPFPLLMNRQRMPK------------------VLVENA 305

  Fly   316 RNVRYCVDPLNTGNKEI-HYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRYGIQDFTPLP 379
            :|...||  |...::|: .:|..||..:|..:.:.||...|.:.||||:.:|:.::|:.|..|:.
Mouse   306 KNFPKCV--LEISDQEVLEWYTAKDFIVGKPLTILGRTFFIYDCDPFTRQFYKDKFGMPDLPPVD 368

  Fly   380 IPARSDDCADHRSERQLPPYNGWGSYEDSVGNCISVEPKPPKSDFKKFIKYDRYVLRFGAKMLST 444
            :..:.....    :::||||||:|..|||..||.::.||.|:.|..|.:..|..|||:.|.:.|.
Mouse   369 VTKKEPPPV----KQELPPYNGYGLIEDSAQNCFALIPKAPRKDVVKMLMNDNKVLRYLAALESP 429

  Fly   445 IKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERFS-CKQPQYYMPWNF 508
            |..:.:|.||.||:|..|.:.|.|..|||||.:||:|:.||::    .:.|| ...|.||.|.:|
Mouse   430 IPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKFLGRTKV----VKSFSPVDNPIYYSPSDF 490

  Fly   509 FVGSTMSLKDFIFHIVSADEYTLMYMEHHPEIFPHANVGVIMEKVKSALQNRMAEFVGSCVPD-- 571
            |:|:.:.:....|.|:..|||.|.|||        :|......:..:::|||:.:      |:
Mouse   491 FIGAVIEVFGHRFVILDTDEYVLKYME--------SNASQYSPEALASIQNRIQK------PELP 541

  Fly   572 CTDLEKKR----DVFVSFESFKGALISIMGNQISDHEIISLCRHFSAE------KSQPNACDRST 626
            ..:||.|:    .:....|..|...:..:.:||..|...:.|:....|      |.:....||.|
Mouse   542 APELESKQATGEPMVQGTEESKVQDLDALIDQIHMHLKYNSCKENLRETFQMYDKDESGYVDRET 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.1	NP_573075.1	DM10	82..189	CDD:128921	44/106 (42%)
		DUF1126	110..142	CDD:284078	17/31 (55%)
		DM10	232..370	CDD:128921	48/139 (35%)
		DUF1126	256..288	CDD:284078	16/31 (52%)
		DM10	431..538	CDD:128921	44/107 (41%)
		DUF1126	454..486	CDD:284078	16/31 (52%)
Efhc1	NP_082250.1	Required for its localization in the mitotic spindle and interaction with alpha-tubulin. /evidence=ECO:0000250\|UniProtKB:Q5JVL4	1..45		11/38 (29%)
		DM10	93..198	CDD:128921	44/106 (42%)
		DUF1126	122..153	CDD:284078	17/30 (57%)
		DM10	239..359	CDD:128921	48/139 (35%)
		DUF1126	263..296	CDD:284078	16/32 (50%)
		DM10	416..520	CDD:128921	44/115 (38%)
		DUF1126	439..471	CDD:284078	16/31 (52%)
		EFh	587..647	CDD:238008	4/19 (21%)
		EF-hand_7	587..646	CDD:290234	4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8231
eggNOG	1	0.900	-	-		E1_KOG0043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56477
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101134
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720