DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Efhc1.1 and efhc1

DIOPT Version :9

Sequence 1:	NP_573075.1	Gene:	Efhc1.1 / 32528	FlyBaseID:	FBgn0030691	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_957261.1	Gene:	efhc1 / 393942	ZFINID:	ZDB-GENE-040426-1300	Length:	554	Species:	Danio rerio

Alignment Length:	589	Identity:	192/589 - (32%)
Similarity:	296/589 - (50%)	Gaps:	69/589 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GMPLLPGTLFRDVSKGHYPKPQSLANVQGLSMLSDRQQPAPV----------------ESGSVTV 54
            |:|.|||..|||::|..:.:.|:|....|.:     |...||                |...:..
Zfish     8 GLPFLPGNTFRDLTKSAFHRAQTLDFKNGYA-----QPRRPVVGIGQDPLLSVNISHSERNQLIT 67

  Fly    55 DISCPPVGASSIYPPRSGPRMPPWLAYDKKVLCFHAYFKQTLQEVYHAPYLVRKVKIYYYLEDGT 119
            ||.....|....:.|..  .:|...|||||||.|:.||:|.:...:...:.:|.|..||:|||.:
Zfish    68 DIPNLTYGTDRSHLPLE--FIPAHAAYDKKVLRFYGYFRQEVLHSWDEHFRIRPVVFYYHLEDDS 130

  Fly   120 LEIYEPRVDNSGIVQGCVVHRQRVQKAPPCDNEFMSLIDLNVDQTVQIFDRQYHITDCDPFTRTF 184
            :.:.||.|:||||.||.::.|||:.|.|..|  .....||||...:.:|...|.||.|||||:.|
Zfish   131 ICVTEPPVENSGIPQGKLIKRQRLSKNPRGD--LYHWKDLNVGMDINLFGEVYRITHCDPFTQDF 193

  Fly   185 LNKRGITVPDPVKSPCDPTEEQRKRENQPRSGNLIP--KNHPFAQFLKYDRQILKFQAYWDDRTE 247
            :..:||.:.:....|.||...:|....|.   ::.|  .||...:||..|||:|:|.|.|||...
Zfish   194 MESQGIVLNEFESIPSDPYTARRAHNQQT---HITPYDHNHQLERFLALDRQVLRFFALWDDSDS 255

  Fly   248 -FGDVRKLELCYYLSDDTIEIKEQHIRNSGRDGPTVFLKRGRLAREFEGLQLPGQMTPMTLLNVL 311
             :|:.|.:.|.|||.||::||.|.|..|||||...|.|:|.::.:..:....|   .|..:|.|.
Zfish   256 LYGEKRPVTLHYYLVDDSVEICEHHEANSGRDPFPVLLRRQKIPKHIKPTCEP---FPSCVLEVS 317

  Fly   312 GTNMRNVRYCVDPLNTGNKEIHYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRYGIQDFT 376
            ..:::                .|:..:|.::|..:|:.||..::.:.|.||..||:..:     .
Zfish   318 PHDVK----------------EYFCPQDFRVGEEVNLMGRRFLLYDCDDFTHKYYQHHH-----P 361

  Fly   377 PLPI-PARSDDCADHRSERQLPPYNGWGSYEDSVGNCISVEPKPPKSDFKKFIKYDRYVLRFGAK 440
            .:|| |...|.......:|.:|||||:||.|||:.||:|:.|:|||.:..|.::.|..|||:.|:
Zfish   362 DIPIKPFTVDTRTQQDIKRVIPPYNGFGSLEDSLQNCLSLIPQPPKKNVIKLLENDHKVLRYAAR 426

  Fly   441 MLSTIKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERFSCKQPQYYMP 505
            :.|....:..|.|::|::|.||.:.|.|.:.||||.:||:|:::||:..||.   :.::|:||.|
Zfish   427 LDSQNPLDEGRRFILSFHLADDMISIFEKSTRNSGIIGGKFLEKTRIPKPGS---TAEKPEYYQP 488

  Fly   506 WNFFVGSTMSLKDFIFHIVSADEYTLMYMEHHPEIFPHANVGVIMEKVKSALQNRMAEFVGSCVP 570
            .:..||:|:.:....|.:..||.:.|.::|......|        |...|:|  |.|.......|
Zfish   489 ADLCVGATVEVFGHRFVVTDADRFVLSFLESQSHQTP--------EHTLSSL--RHATDPQQLHP 543

  Fly   571 DCTD 574
            :|.:
Zfish   544 ECDE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.1	NP_573075.1	DM10	82..189	CDD:128921	45/106 (42%)
		DUF1126	110..142	CDD:284078	15/31 (48%)
		DM10	232..370	CDD:128921	44/138 (32%)
		DUF1126	256..288	CDD:284078	18/31 (58%)
		DM10	431..538	CDD:128921	37/106 (35%)
		DUF1126	454..486	CDD:284078	13/31 (42%)
efhc1	NP_957261.1	DM10	93..198	CDD:128921	45/106 (42%)
		DUF1126	121..153	CDD:284078	15/31 (48%)
		DM10	240..356	CDD:128921	42/134 (31%)
		DUF1126	264..297	CDD:284078	18/32 (56%)
		DM10	417..521	CDD:128921	37/106 (35%)
		DUF1126	440..472	CDD:284078	13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56477
OrthoDB	1	1.010	-	-		D126718at33208
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101134
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730