DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Efhc1.1 and Efhc2

DIOPT Version :9

Sequence 1:	NP_573075.1	Gene:	Efhc1.1 / 32528	FlyBaseID:	FBgn0030691	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001100422.1	Gene:	Efhc2 / 302507	RGDID:	1563388	Length:	750	Species:	Rattus norvegicus

Alignment Length:	761	Identity:	246/761 - (32%)
Similarity:	404/761 - (53%)	Gaps:	109/761 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MPLLPGTLF-RDVSKGHYPKPQSLANVQGLSMLSDRQQPAPVESGSVTVDISCPPVGASSIYPPR 70
            :|||||..| |::.|..:.:.|.......:.||....:|.  ..|.:.......|  ..|::|..
  Rat     3 LPLLPGNSFNRNIGKEKFHRSQHWGFCNNVRMLVSEDKPG--IGGDLLPGQKIKP--KHSVFPKG 63

  Fly    71 SGPRMPPWLAYDKKVLCFHAYFKQTLQEVYHAPYLVRKVKIYYYLEDGTLEIYEPRVDNSGIVQG 135
            .|...|.|:|:||:||.|.||.:..:.:.....:.:|..|||:||||.|:::.||.|.|||:.||
  Rat    64 DGTDAPSWVAFDKQVLSFDAYLEDEVPDKRQENFRIRYYKIYFYLEDDTIQVNEPEVINSGLPQG 128

  Fly   136 CVVHRQRVQKAPPCDNEFMSLIDLNVDQTVQIFDRQYHITDCDPFTRTFLNKRGITVPDPVKSPC 200
            ..:.|.|:...||.|::|.::.|.|::.:|..:.|.:.|.||||||:.||.|.||.:..|.:.|.
  Rat   129 TSIRRHRIPFPPPYDDQFYTVYDFNINISVVFYGRTFKIYDCDPFTKNFLRKIGIKLNPPGQRPF 193

  Fly   201 DPTEEQRKRENQPRSGNLIPKNHPF------AQFLKYDRQILKFQAYWDDRTE-FGDVRKLELCY 258
            ||..:.|:...:     .:....|:      .:||:||.::|:|...|||... |||.|:..|.|
  Rat   194 DPYMKMRRETLE-----FVDPFRPYQSFDTLKRFLQYDGKVLRFFCLWDDSASLFGDRREFVLHY 253

  Fly   259 YLSDDTIEIKEQHIRNSGRDGPTVFLKRGRLAREF--EGLQLPGQMTPMTLLNVLG--TNMRNVR 319
            :|.||||||:|....|||||..:.||:|.:|.: |  .|:..|||:|...:|||.|  :..|...
  Rat   254 FLCDDTIEIREILPSNSGRDAMSSFLRRSKLPK-FGPPGIYQPGQITDRAVLNVYGGLSEWRADG 317

  Fly   320 YCVDPLNTGNKEIHYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRYGIQDFTPL-----P 379
            |.:|....|..|..:|.::||.||:.|||:||.|::.:.|.||:.||:.:||:.:|||:     |
  Rat   318 YLLDKYQLGKIEQDFYTDQDLSIGATINVWGRKVLLCDCDEFTKTYYKTKYGVDNFTPISCKPPP 382

  Fly   380 IPARSDDCADHRSERQLPPYNGWGSYEDSVGNCISVEPKPPKSDFKKFIKYDRY-----VLRFGA 439
            :|         :.:|:.|||.|:||.|||..:|:|::|.|.:.:|:||::.|.:     :||:.|
  Rat   383 LP---------KIKRKYPPYTGFGSEEDSFRSCVSLKPTPHRKNFRKFMELDSFGNVSNILRYFA 438

  Fly   440 KMLSTIKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERFSCKQPQYYM 504
            |:::...|:.:|:|||::||.|||:.:.|...||||..||.|:||:|::.||||.|..:..:|..
  Rat   439 KLITHKCADVDRMFVIAFYLSDDTISVFEPIERNSGNAGGMFLKRSRVKKPGQEVFKSEFSEYVK 503

  Fly   505 PWNFFVGSTMSLKDFIFHIVSADEYTLMYMEHHPEIFPHANVGVIMEKVKSALQNRMAEFVGSCV 569
            ....::|:|:::..::|.:::||||||.|||.:.:.||::|..:.::|:|.
  Rat   504 AEELYIGATVNINGYLFLLLNADEYTLNYMESNTDRFPYSNFELAIQKLKH-------------- 554

  Fly   570 PDCTDLEKKRDV-------------FVSFESFKGALISI-MGNQISDHEIISLCRHFSA-EKSQP 619
                :..|.|::             .|.:.:|:..|:|| |||.| |.|:|::.||:.. |...|
  Rat   555 ----EKSKSREITQVFAAADYNHTKVVPYNAFRDILMSITMGNLI-DQELITIARHYRVPEVMDP 614

  Fly   620 NACDRSTVRAAAHLELKRTLWNARDDLMEHFHHINPTNQPFLPEVKVRSALRGCRLPFSLELIDN 684
               |.:.:.|.||.:.|:.::...|..:.:..:.:...:..||...::...:..|||.|.:.:|.
  Rat   615 ---DLAYLIAQAHEKFKKNMFENFDMFIYNCVYEDRERKGVLPTTDIKRMCKSSRLPLSDDFLDC 676

  Fly   685 IL----------------SILN---------------RNECDDIEV 699
            :|                |:||               :.:|:|:.|
  Rat   677 LLSRFEDKDQQINYEIFFSLLNWRMNPTPDLQAPPYLKEKCEDVWV 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.1	NP_573075.1	DM10	82..189	CDD:128921	44/106 (42%)
		DUF1126	110..142	CDD:284078	17/31 (55%)
		DM10	232..370	CDD:128921	60/142 (42%)
		DUF1126	256..288	CDD:284078	18/31 (58%)
		DM10	431..538	CDD:128921	44/111 (40%)
		DUF1126	454..486	CDD:284078	17/31 (55%)
Efhc2	NP_001100422.1	DM10	75..182	CDD:128921	44/106 (42%)
		DUF1126	103..135	CDD:284078	17/31 (55%)
		DM10	226..368	CDD:128921	60/142 (42%)
		DUF1126	250..283	CDD:284078	18/32 (56%)
		DM10	431..537	CDD:128921	43/105 (41%)
		DUF1126	453..485	CDD:284078	17/31 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340995
Domainoid	1	1.000	110	1.000	Domainoid score	I6175
eggNOG	1	0.900	-	-		E1_KOG0043
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11863
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1780
OMA	1	1.010	-	-		QHG56477
OrthoDB	1	1.010	-	-		D126718at33208
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	1	1.000	-	-		otm45361
orthoMCL	1	0.900	-	-		OOG6_101134
Panther	1	1.100	-	-	O	PTHR12086
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4557
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770