DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Efhc1.1 and Efhc1

DIOPT Version :9

Sequence 1:	NP_573075.1	Gene:	Efhc1.1 / 32528	FlyBaseID:	FBgn0030691	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001116419.2	Gene:	Efhc1 / 301295	RGDID:	1587365	Length:	648	Species:	Rattus norvegicus

Alignment Length:	717	Identity:	219/717 - (30%)
Similarity:	341/717 - (47%)	Gaps:	115/717 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IPGMPLLPGTLFRDVSKGHYPKPQSLANVQGLSML--------SDR---QQPAPVESGSVTVDIS 57
            :.|:|||||:.|.|.:|..:.:.|:|....|.:.:        .||   .|.:|.|...:.   :
  Rat     6 VHGLPLLPGSSFTDSTKTAFHRSQTLGYRNGYAFVRRPTMGIGGDRLPYNQLSPAELDELA---N 67

  Fly    58 CPPVGASSIYPP--RSGPR--MPPWLAYDKKVLCFHAYFKQTLQEVYHAPYLVRKVKIYYYLEDG 118
            ..|:   ..|.|  ::.|.  :|..:|:|||||.|.|||::.:.......|.:|:|.|||||||.
  Rat    68 KAPI---LTYGPLKQAAPAEFVPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRRVNIYYYLEDD 129

  Fly   119 TLEIYEPRVDNSGIVQGCVVHRQRVQKAPPCDNEFMSLIDLNVDQTVQIFDRQYHITDCDPFTRT 183
            ::.:.||.|:||||.||.:|.|||:.|....|:....  |||....:.|:.:.:.|.|||.||:.
  Rat   130 SMSVIEPVVENSGIPQGKLVKRQRLAKNDVGDHYHWK--DLNRGINLTIYGKTFRIVDCDRFTQD 192

  Fly   184 FLNKRGITVPDPVKSPCDPTEEQRKRENQPRSGNLIPKN-HPFAQFLKYDRQILKFQAYWDDRTE 247
            ||..:||.:....|.|.||..|.||   :|....:.|.: ....|||.:|:|:|:|.|.|||...
  Rat   193 FLESQGIELNPSEKMPLDPYTELRK---EPVRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDS 254

  Fly   248 -FGDVRKLELCYYLSDDTIEIKEQHIRNSGRDGPTVFLKRGRLAREFEGLQLPGQMTPMTLLNVL 311
             ||:.|...:.|||.|||:||:|.|.||:|||...:.:.|.|:.:                  ||
  Rat   255 LFGECRHYIIHYYLMDDTVEIREVHERNNGRDPFPLLMNRQRMPK------------------VL 301

  Fly   312 GTNMRNVRYCVDPLNTGNKEI-HYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRYGIQDF 375
            ..|.:|...||  |...::|: .:|..||..:|..:.:.||...|.:.||||:.:|:.::|:.|.
  Rat   302 VDNGKNFPQCV--LEISDQEVLEWYTAKDFIVGKPLTILGRTFFIYDCDPFTRQFYKDKFGMSDL 364

  Fly   376 --------TPLPIPARSDDCADHRSERQLPPYNGWGSYEDSVGNCISVEPKPPKSDFKKFIKYDR 432
                    .|.|:            :::||||||:|..|||..||.::.||.|:.|..|.:..|.
  Rat   365 PRVDVSKKEPPPV------------KQELPPYNGYGLIEDSAQNCFALVPKAPRKDIVKMLMNDN 417

  Fly   433 YVLRFGAKMLSTIKANCERIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERFS- 496
            .|||:.|.:.|.|..:.:|.||.||:|..|.:.|.|..|||||.:||:|:.||::    .:.||
  Rat   418 KVLRYLAALESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKFLGRTKV----VKSFSP 478

  Fly   497 CKQPQYYMPWNFFVGSTMSLKDFIFHIVSADEYTLMYMEHHPEIFPHANVGVIMEKVKSALQNRM 561
            ...|.||.|.:||:|:.:.:....|.|:..|||.|.|||        :|......:..:::|||:
  Rat   479 VDNPIYYGPSDFFIGAVIEVFGHRFVILDTDEYVLKYME--------SNASQYSPEALASIQNRI 535

  Fly   562 AEFVGSCVPDCTDLEKKRDVFVSFESFKGALISIMGNQISDHEIISLCRHFSAEKSQPNACDRST 626
            .: ..|..|   :||.|:    :.|..|.                     .:.|:.:....|:..
  Rat   536 RK-QDSPAP---ELECKQ----ATEETKA---------------------LATEELKAQGLDKLI 571

  Fly   627 VRAAAHLELKRTLWNARDDLMEHFHHINPTNQPFLPEVKVRSALRGCRLPFSLELIDNILSILNR 691
            .:...||:    ..:.:|:|.|.|...:.....::.:...........:|....||..::.:...
  Rat   572 EKIQMHLK----DISCKDNLRERFQVYDKEESGYVDKETFFKVCETLNVPVDDSLIKELIRLCTH 632

  Fly   692 NE 693
            .|
  Rat   633 GE 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.1	NP_573075.1	DM10	82..189	CDD:128921	46/106 (43%)
		DUF1126	110..142	CDD:284078	18/31 (58%)
		DM10	232..370	CDD:128921	48/139 (35%)
		DUF1126	256..288	CDD:284078	16/31 (52%)
		DM10	431..538	CDD:128921	44/107 (41%)
		DUF1126	454..486	CDD:284078	16/31 (52%)
Efhc1	NP_001116419.2	DM10	93..198	CDD:128921	46/106 (43%)
		DUF1126	122..153	CDD:284078	18/30 (60%)
		DM10	239..359	CDD:128921	48/139 (35%)
		DUF1126	263..296	CDD:284078	16/32 (50%)
		DM10	416..520	CDD:128921	44/115 (38%)
		DUF1126	439..471	CDD:284078	16/31 (52%)
		EFh	587..647	CDD:238008	7/48 (15%)
		EF-hand_7	587..646	CDD:290234	7/48 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8056
eggNOG	1	0.900	-	-		E1_KOG0043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56477
OrthoDB	1	1.010	-	-		D126718at33208
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101134
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730