DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Efhc1.1 and efhc2

DIOPT Version :9

Sequence 1:	NP_573075.1	Gene:	Efhc1.1 / 32528	FlyBaseID:	FBgn0030691	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001136133.1	Gene:	efhc2 / 100126059	XenbaseID:	XB-GENE-960325	Length:	741	Species:	Xenopus tropicalis

Alignment Length:	729	Identity:	253/729 - (34%)
Similarity:	407/729 - (55%)	Gaps:	62/729 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MPLLPGTLF-RDVSKGHYPKPQSLANVQGLSMLSDRQQPAPVESGSVTVDISCPPVGASSIYPPR 70
            :|.|||..| |::.|..:.|.|.......:||....::|.  ..|:..:..:..|  ..|::|..
Frog     3 LPFLPGNSFNRNLGKEKFHKSQHFGYSNDISMWLGEEKPG--VGGAPLLGQNLKP--KFSVFPKG 63

  Fly    71 SGPRMPPWLAYDKKVLCFHAYFKQTLQEVYHAPYLVRKVKIYYYLEDGTLEIYEPRVDNSGIVQG 135
            .|...|.|:|:||:||.|.|||::.:.:.....|.:|:.|||:||||.|:::.||.:.||||.||
Frog    64 VGSDAPSWVAFDKQVLSFDAYFEEEVHQRREETYRIRQCKIYFYLEDDTIQVVEPEIKNSGIPQG 128

  Fly   136 CVVHRQRVQKAPPCDNEFMSLIDLNVDQTVQIFDRQYHITDCDPFTRTFLNKRGITVPDPVKSPC 200
            .::.|.|:....|.|::|.::..||:::.:..:.:.|.|.:||.|||.||.|.|:.:..|...|.
Frog   129 TIIRRHRIPLPAPNDDQFYTVDHLNLNKDIVFYSKIYRIVNCDEFTRNFLRKLGVRINPPDSVPS 193

  Fly   201 DPTEEQRKR--ENQPRSGNLIP--KNHPFAQFLKYDRQILKFQAYWDDRTEFGDVRKLELCYYLS 261
            |.....||:  |.||    |.|  :.....|||::||.:|:|..:|||.|.|||.|:|.|.|||:
Frog   194 DAYSSTRKKMEEMQP----LRPYERIDTLKQFLEHDRHVLRFFCFWDDTTLFGDSRELVLYYYLA 254

  Fly   262 DDTIEIKEQHIRNSGRDGPTVFLKRGRLAREF-EGLQLPGQMTPMTLLNVLGTNMRNVRYCVDPL 325
            |||:||.|....|||||...|||.||:|.:.. :.:..|||:|..|:|||.|......||.:|.|
Frog   255 DDTVEILEIIPANSGRDTTPVFLHRGKLPKSSPQNVPQPGQVTARTVLNVFGPMGHGGRYILDNL 319

  Fly   326 NTGNKEIHYYREKDLQIGSVINVYGRAVVITELDPFTQNYYRQRYGIQDFTPLPIPARSDDCADH 390
            .||.....:|::.||.||:.:||:||.|::.:.|.||:|||:.::||:||||:...|....
Frog   320 KTGAVHEEFYKDSDLTIGAALNVWGRKVILCDCDEFTKNYYKTKFGIEDFTPVQYKAPQPP---- 380

  Fly   391 RSERQLPPYNGWGSYEDSVGNCISVEPKPPKSDFKKFIKYDR-----YVLRFGAKMLSTIKANCE 450
            |.:::.|||||:||..|::.:|:::.||||:.|||||::.||     .||||.|::.:....:.|
Frog   381 RPKKEFPPYNGFGSEADTLCSCMALLPKPPQRDFKKFMEKDRNGLESNVLRFVARLDTDNPIDKE 445

  Fly   451 RIFVISYYLCDDTLQIQEIAVRNSGFLGGEFMKRTRLELPGQERFSCKQPQYYMPWNFFVGSTMS 515
            |.|::||:|.|||:.:.|...||||.:||:|::|:|::.|||:.|..:..:|:.|.:.|||:.::
Frog   446 RKFIVSYFLSDDTVTVFEPQERNSGMVGGKFLERSRVKKPGQQLFKSELSEYFRPEDLFVGARVN 510

  Fly   516 LKDFIFHIVSADEYTLMYMEHHPEIFPHANVGVIMEKVKSALQNRMAEFVGSCVPDCTDLEKKRD 580
            ...|:|.:|.||||...|||.:...||.:::.||..|::     |:.|            .|.|:
Frog   511 FNGFLFILVDADEYVFNYMERNANEFPMSDISVITSKLR-----RIGE------------TKSRE 558

  Fly   581 VFVSFES-------------FKGALISIMGNQISDHEIISLCRHFSAEKSQPNACDRSTVRAAAH 632
            :...||:             |:..|:.|..||:::|||::..|::|. :.:|. .|..::.|.|.
Frog   559 IKQHFEANDPTGTSHMPYEIFRNLLVDIYANQLTEHEIMTTGRYYSI-RDKPE-IDLGSLTAIAQ 621

  Fly   633 LELKRTLWNARDDLMEHFHHINPTNQPFLPEVKVRSALRGCRLPFSLELIDNILSILNRNECDDI 697
            .:||:..:.....|.:.|.:.:.....:|...|..:..:..::|    |.|:.|.:|.....::
Frog   622 EQLKKKSFENFSKLSDVFVYNDQEKNGWLSFQKTLTICKAFKIP----LADDFLRVLLEKHTEN- 681

  Fly   698 EVCDLMNFIDVSCG 711
              .|.:|:|.:..|
Frog   682 --GDQVNYISLVTG 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.1	NP_573075.1	DM10	82..189	CDD:128921	43/106 (41%)
		DUF1126	110..142	CDD:284078	17/31 (55%)
		DM10	232..370	CDD:128921	65/138 (47%)
		DUF1126	256..288	CDD:284078	19/31 (61%)
		DM10	431..538	CDD:128921	45/111 (41%)
		DUF1126	454..486	CDD:284078	15/31 (48%)
efhc2	NP_001136133.1	DM10	75..180	CDD:128921	42/104 (40%)
		DUF1126	103..135	CDD:284078	17/31 (55%)
		DM10	225..364	CDD:128921	65/138 (47%)
		DUF1126	248..281	CDD:284078	19/32 (59%)
		DM10	427..533	CDD:128921	43/105 (41%)
		DUF1126	449..481	CDD:284078	15/31 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4677
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11863
Inparanoid	1	1.050	450	1.000	Inparanoid score	I1576
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126718at33208
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	1	1.000	-	-		otm48437
Panther	1	1.100	-	-	O	PTHR12086
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160