Protein Alignment CG8952 and F10

DIOPT Version :10

• Sequence 1: NP_573072.1
• Gene: CG8952 / 32525
• FlyBaseID: FBgn0030688
• Length: 276
• Species: Drosophila melanogaster
• Sequence 2: NP_000495.1
• Gene: F10 / 2159
• HGNCID: 3528
• Length: 488
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 71/289 - (24%)
• Similarity: 126/289 - (43%)
• Gaps: 61/289 - (21%)

  Fly    18 SVVGQPFDPAN---------------SSPIKIDN---RIVSGSDAKLGQFPWQVILKRDAWDDLL 64
            |:..:|:|.|:               :.|.:.||   |||.|.:.|.|:.|||.:|..:. ::..
Human   197 SITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEE-NEGF 260

  Fly    65 CGGSIISDTWVLTAAHCTNGLSSIFLMFGTVDLFNANALNMTSNN-----------------III 112
            |||:|:|:.::||||||               |:.|....:...:                 :|.
Human   261 CGGTILSEFYILTAAHC---------------LYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIK 310

  Fly   113 HPDY-NDKLNNDVSLIQLPEPLTFSANIQAIQLVGQ-YGDSIDYVGSVATIAGFGYTEDEYLDYS 175
            |..: .:..:.|:::::|..|:||..|:....|..: :.:|.........::|||.|.::... |
Human   311 HNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQ-S 374

  Fly   176 ETLLYAQVEIIDNADCVAIYGKYVVVDSTMCAKGFDGSDMSTCTGDSGGPLILYNKTIQQWQQIG 240
            ..|...:|..:|...| .:...:::..:..|| |:|......|.||||||.:...|  ..:...|
Human   375 TRLKMLEVPYVDRNSC-KLSSSFIITQNMFCA-GYDTKQEDACQGDSGGPHVTRFK--DTYFVTG 435

  Fly   241 INSFVAEDQCTYRLPSG-YARVSSFLGFI 268
            |.|:  .:.|..:...| |.:|::||.:|
Human   436 IVSW--GEGCARKGKYGIYTKVTAFLKWI 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8952	NP_573072.1	Tryp_SPc	37..268	CDD:214473	63/250 (25%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:464251
		O-glycosylated at one site	183..203		1/5 (20%)
		Tryp_SPc	235..464	CDD:238113	63/251 (25%)
		O-glycosylated at one site	476..485