DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIIIC160 and RPA190

DIOPT Version :9

Sequence 1:	NP_001096987.2	Gene:	RpIIIC160 / 32524	FlyBaseID:	FBgn0030687	Length:	1383	Species:	Drosophila melanogaster
Sequence 2:	NP_014986.3	Gene:	RPA190 / 854519	SGDID:	S000005868	Length:	1664	Species:	Saccharomyces cerevisiae

Alignment Length:	1710	Identity:	457/1710 - (26%)
Similarity:	722/1710 - (42%)	Gaps:	423/1710 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LNKKISHVQFGISGADEIQQEALVRIISKNLYQAQRQPVPYGVLDRRMGISTKDAMCETCGQGLN 75
            :..:|:.|.|||..|.||:..:..:|.:..:......||..|:.|..:|...:: :|.|||....
Yeast     7 VGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN-LCSTCGLDEK 70

  Fly    76 ECIGHFGYLDLALPVFHIGHFRSTINILQMICKVCAHVMLKPEDRQLYEKKLHNPNF-----SY- 134
            .|.||.|:::|.:|.::...|......|:..|..|.|..||..:...|..||....:     ||
Yeast    71 FCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYK 135

  Fly   135 -----LG-----------------------------------------KKALHVQM-LAKA---- 148
                 ||                                         |::.:|.| :|||
Yeast   136 LDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNELKSKRSEYVDMAIAKALSDG 200

  Fly   149 ----------------KKVT-----------KCPHCG--SP---------------------NGG 163
                            ||:.           ||.:||  ||                     |..
Yeast   201 RTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNR 265

  Fly   164 VKKGPGLLK--ILHDPYKGRKMDSLFTSNMN-----EMLRSTQTNRDLNSTLGNYSTAEELTPLM 221
            ||   |.::  ::....:.:|:|....::.|     ::.|:..|.....||   |..:.|
Yeast   266 VK---GFIRQDMIKKQKQAKKLDGSNEASANDEESFDVGRNPTTRPKTGST---YILSTE----- 319

  Fly   222 VLDLFEQIPQRDVALLGMCSHDAHP---KHLIVTRVF------VPPACIR-PSVLSEVKAGTTED 276
            |.::.:.:.:::..:|....| :.|   :.|:....|      |||...| ||.|.|.....:::
Yeast   320 VKNILDTVFRKEQCVLQYVFH-SRPNLSRKLVKADSFFMDVLVVPPTRFRLPSKLGEEVHENSQN 383

  Fly   277 DLTMK-QSEILLINDV------IQRHMATGGKIELIHEDWDFLQL-HVALYFHSEISG-IPINMA 332
            .|..| .:..|||.|:      :|:     .|:.|......|.:| :..:...::::. |....|
Yeast   384 QLLSKVLTTSLLIRDLNDDLSKLQK-----DKVSLEDRRVIFSRLMNAFVTIQNDVNAFIDSTKA 443

  Fly   333 PKKTT-----RGIVQRLKGKQGRFRCNLSGKRVDFSGRTVISPDPNLMINQVGVPVRVAKILTYP 392
            ..:|:     .|:.|.|:.|:|.||.::.||||:::.|:|||||||:..|::|||...|..||||
Yeast   444 QGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAARSVISPDPNIETNEIGVPPVFAVKLTYP 508

  Fly   393 ERVNPANIRHMRELVRNGPSMHPGANYVQQRGSSFKKYLAYG--NREKVAQEL----------KC 445
            |.|...||..:|:.|.|||...|||..:|....|....:...  .|:.:|.:|          ..
Yeast   509 EPVTAYNIAELRQAVINGPDKWPGATQIQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVSTHTL 573

  Fly   446 GDVVERHLRDGDIVLFNRQPSLHKMSIMCHRAKVQP-QRTFRFNECACTPYNADFDGDEMNLHLP 509
            ...|.||:::.|:||.||||:|||.|:|.|:.:|.| ::|.|.:......|||||||||||:|.|
Yeast   574 NKKVYRHIKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFP 638

  Fly   510 QTEEARAEALILMGNQSNLVTPKNGEILIAATQDFITGGYLLTQKEVFLTKEEAMQ-LAACFLAN 573
            |.|.||||||.|....|..:||.:|..:....||.|:.|..||.|:.|.|:|:..| :..|....
Yeast   639 QNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPE 703

  Fly   574 EDSTMHIKLP--PPALLKPRRLWTGKQMFS---LLMRPNDDSQVRLNMVNKGRNYTRNKDLCSND 633
            :..|...|:.  ||.:.||..||||||:.:   |.:.|.|...:.|...||.:|....|....|:
Yeast   704 DGHTTRSKIVTLPPTIFKPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENE 768

  Fly   634 SWIHIRNSELMCGVMDKATMGSGTKQCIFYLLLRDFGESHATKAMWRLARIASYFLQNRGFSFGI 698
              :..::..|:||::||:..|: :|..|.:.|...:|...|.|.:..|.|:.:.::....|:.|:
Yeast   769 --VLFKDGALLCGILDKSQYGA-SKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGM 830

  Fly   699 SDV----------------------------------TPS--KKLLQH-KELLLNNGYAKCNEYI 726
            .|:                                  ||:  .:||:. :|:|.:|.
Yeast   831 DDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNN-------- 887

  Fly   727 ELLKAGTLQCQPGCTPEETLESVMLRELSAIREQAAKTCFAE----LHPTNSALIMALSGSKGSN 787
               |:|            .|::|...:::||..|....|..:    ..|.||...|||||:||||
Yeast   888 ---KSG------------ILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSN 937

  Fly   788 INISQMIACVGQQAISGKRVPNGFENRALPHFERHSAIPAARGFVQNSFYSGLTPTEFFFHTMAG 852
            :|:||::..:||||:.|:|||.....:.||.|:.:.....|.|:|:..||||:.|.|::||.|||
Yeast   938 VNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAG 1002

  Fly   853 REGLVDTAVKTAETGYLQRRLVKCLEDLVVHYDGTVRNAVNEMVDTIYGGDGLDPVSMETRNKPV 917
            ||||:||||||:.:|||||.|.|.||.:.|.||.::|:|...:|..:||||.:| ::.|:.....
Yeast  1003 REGLIDTAVKTSRSGYLQRCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAID-ITKESHMTQF 1066

  Fly   918 D--LVHQYDNLRAQHPQGKDRPLNAEEMSEALETLLRTPEFAEARDDFKLDVR-----------N 969
            :  |.:.|..|:..:|......|:.|...:..:..|:..:.......:|..|:           .
Yeast  1067 EFCLDNYYALLKKYNPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAK 1131

  Fly   970 HINTVSKRIGQLQKRYEKCIDLCHQIECLTTEQLLQFVRRIND---------RYNRAVTEPGTAV 1025
            ::.:||:   ..|.:.|..:|        ...:|.:....:|:         :|.|::..||.||
Yeast  1132 YLGSVSE---NFQDKLESFLD--------KNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAV 1185

  Fly  1026 GAIAAQSIGEPGTQMTLKTFHFAGVASMNITQGVPRIVEII-NATKTISTPIITAELENCHSMEF 1089
            |.||:||:|||.|||||.||||||..:.|:|.|:||:.||: .|:..|.||.:|..:.|..|.|.
Yeast  1186 GIIASQSVGEPSTQMTLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQ 1250

  Fly  1090 ARQVKARIEKTTLAELSSYVEVVCGPYSCYLAIG---------------------VDMARIKLLG 1133
            |......|.|..|:|:...|.|.....:...|.|                     .|:::.:|..
Yeast  1251 ADTFCKSISKVLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQN 1315

  Fly  1134 ------LHIDLDTIVFSILKSRMRVKPTQVEV--------VASQSRIVVRVEATRTSTINAELAR 1184
                  :|: |:..:...:|.:.|.....:.|        ||:.|....|:|.......:.:..:
Yeast  1316 VISNQFIHL-LEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTK 1379

  Fly  1185 LALS--------------------------------------------LQNVVVAGLPNINR--- 1202
            .|:|                                            :...:|....|:|:
Yeast  1380 QAVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMNKVQR 1444

  Fly  1203 ----AVIA---------VDD---------------------------------ARQPPTYKLCI- 1220
                |:|:         .||                                 .||.|....|:
Yeast  1445 DRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQIPHIDRCVH 1509

  Fly  1221 -EGYGLRDVIATYGV-------------VGKRTRSNNICEIYQTLGIEAARTIIMSEITEVMEGH 1271
             |....:.|:.|.||             |...| ||::..:.:|.|:||||..|::||..|...:
Yeast  1510 PEPENGKRVLVTEGVNFQAMWDQEAFIDVDGIT-SNDVAAVLKTYGVEAARNTIVNEINNVFSRY 1573

  Fly  1272 GMSVDWRHIMLLASQMTARGEVLGITRHGLAKMRESVFNLASFEKTADHLFDAAYYGQTDAINGV 1336
            .:||.:||:.|:|..||.:|..|...|.|: :...|.|...|:|.|...|..|....:.:.::..
Yeast  1574 AISVSFRHLDLIADMMTRQGTYLAFNRQGM-ETSTSSFMKMSYETTCQFLTKAVLDNEREQLDSP 1637

  Fly  1337 SERIILGMPACIGTGIFKLL 1356
            |.||::|....:|||.|.:|
Yeast  1638 SARIVVGKLNNVGTGSFDVL 1657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIIIC160	NP_001096987.2	PRK08566	13..919	CDD:236292	320/1105 (29%)
		RNAP_III_RPC1_N	24..889	CDD:259847	306/1062 (29%)
		RNA_pol_Rpb1_5	839..1304	CDD:282807	160/630 (25%)
		RNAP_III_Rpc1_C	1013..1353	CDD:132723	119/483 (25%)
RPA190	NP_014986.3	RNAP_I_RPA1_N	16..1035	CDD:259844	307/1062 (29%)
RPA190	NP_014986.3	RNA_pol_Rpb1_5	989..1611	CDD:398596	161/636 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810