Protein Alignment RpIIIC160 and Polr1a

DIOPT Version :9

• Sequence 1: NP_001096987.2
• Gene: RpIIIC160 / 32524
• FlyBaseID: FBgn0030687
• Length: 1383
• Species: Drosophila melanogaster
• Sequence 2: NP_113960.2
• Gene: Polr1a / 83581
• RGDID: 620824
• Length: 1716
• Species: Rattus norvegicus
• Alignment Length: 1790
• Identity: 446/1790 - (24%)
• Similarity: 717/1790 - (40%)
• Gaps: 531/1790 - (29%)

  Fly    13 KKISHVQFGISGADEIQQEALVRIISKNLYQAQRQPVPYGVLDRRMGISTKDAMCETCGQGLNEC 77
            :::..:.||:..|:|:::.::..|.:.....:...|...|:.|..:|.:....:|.||.|..|.|
  Rat    10 RRLQGISFGMYSAEELKKLSVKSITNPRYVDSLGNPSADGLYDLALGPADSKEVCSTCVQDFNNC 74

  Fly    78 IGHFGYLDLALPVFHIGHFRSTINILQMICKVCAHVMLKP------------------------- 117
            .||.|::||.|.|::...|.....:|:..|..| |::..|
  Rat    75 SGHLGHIDLPLTVYNPLLFDKLYLLLRGSCLNC-HMLTCPRAAIHLLVCQLKVLDVGALQAVYEL 138

  Fly   118 --------------------EDRQLYEKKLHNPNFSYLGKKALHVQMLAKAKK------------ 150
                                |:.:.|..|:...|.  ||.:..||:.:.:::.
  Rat   139 ERILSRFLEETSDPSAFEIQEELEEYTSKILQNNL--LGSQGAHVKNVCESRSKLVAHFWKTHMA 201

  Fly   151 VTKCPHCGSPNGGVKK-------------------------------GPGLLKILHDPYKGRKMD 184
            ..:||||.:....|:|                               .||:     |..:..|..
  Rat   202 AKRCPHCKTGRSVVRKEHNSKLTITYPAMVHKKSGQKDAELPEGAPAAPGI-----DEAQMGKRG 261

  Fly   185 SLFTSNMNEMLRSTQTNRD--LNSTLGNYSTAEELTPLMVLDLFEQIPQRDVALLGMCSHDAHPK 247
            .|..|:..|.|.:...|..  ||..   :|..:::.|                     ....:|.
  Rat   262 YLTPSSAQEHLFAIWKNEGFFLNYL---FSGLDDIGP---------------------ESSFNPS 302

  Fly   248 HLIVTRVFVPPACIRP------------------SVLSE-------VKAGTTEDDLTMKQSEILL 287
            ...:..:.|||:..||                  :|:.:       :.....|..|..:.:||
  Rat   303 MFFLDFIVVPPSRYRPINRLGDQMFTNGQTVNLQAVMKDAVLIRKLLAVMAQEQKLPCEMTEI-- 365

  Fly   288 INDVIQRHMATGGKI--------------ELIHEDWDFLQLHVALYFHSEISGIPINMAPKKTTR 338
               .|.:...:.|.|              :.::..|..||.||.:.|.|::..:.:...|
  Rat   366 ---TIDKENDSSGAIDRSFLSLLPGQSLTDKLYNIWIRLQSHVNIVFDSDMDKLMLEKYP----- 422

  Fly   339 GIVQRLKGKQGRFRCNLSGKRVDFSGRTVISPDPNLMINQVGVPVRVAKILTYPERVNPANIRHM 403
            ||.|.|:.|:|.||.::.|||||::.|:||.||..:..|::|:|:..|..||||:.|.|.|::.:
  Rat   423 GIRQILEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQEL 487

  Fly   404 RELVRNGPSMHPGANYVQQRGSSFKKYLAYG--NREKVAQEL----------KCGDVVERHLRDG 456
            |:.|.|||::||||:.|.....|.....|..  .||.||::|          :...||.||:::|
  Rat   488 RQAVINGPNVHPGASMVINEDGSRTALSAVDATQREAVAKQLLTPSTGIPKPQGAKVVCRHVKNG 552

  Fly   457 DIVLFNRQPSLHKMSIMCHRAKVQP-QRTFRFNECACTPYNADFDGDEMNLHLPQTEEARAEALI 520
            ||:|.||||:||:.||..|||.:.| ::..|.:...|..|||||||||||.|.||:|..||||.:
  Rat   553 DILLLNRQPTLHRPSIQAHRAHILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYV 617

  Fly   521 LMGNQSNLVTPKNGEILIAATQDFITGGYLLTQKEVFLTKEEAMQLAACFLANEDSTMHIKLPPP 585
            |.......:.||:|:.|....||.:..|..:|.:..|.|:|:.|:|.  :....|....:||.||
  Rat   618 LACTDQQYLVPKDGQPLAGLIQDHMVSGANMTIRGCFFTREQYMELV--YRGLTDKVGRVKLFPP 680

  Fly   586 ALLKPRRLWTGKQMFS-LLMRPNDDSQVRLNMVNK----GRNYTRNK----------DLCSNDSW 635
            |:|||..||||||:.| ||:....:....||:..|    .:.:.:.|          .:|  :|.
  Rat   681 AILKPFPLWTGKQVVSTLLINIIPEDYTPLNLTGKAKIGSKAWVKEKPRPVPDFDPDSMC--ESQ 743

  Fly   636 IHIRNSELMCGVMDKATMGS---GTKQCIFYLLLRDFGESHATKAMWRLARIASYFLQ-NRGFSF 696
            :.||..||:|||:|||..||   |...|.:.:    :|...:.:.:..|||:.:.:|| .|||:.
  Rat   744 VIIREGELLCGVLDKAHYGSSAYGLVHCCYEI----YGGETSGRVLTCLARLFTAYLQLYRGFTL 804

  Fly   697 GISD--VTPSKKLLQHKELLLNNGYAKCNEYIELLKAGTLQCQPGCT------PE---------- 743
            |:.|  |.|:..:::.:                :::..| ||.|...      ||
  Rat   805 GVEDILVKPNADVMRQR----------------IIEEST-QCGPRAVRAALNLPEAASCDEIQGK 852

  Fly   744 -------------ETLESVMLRELSAIREQAAKTCFA-ELH---PTNSALIMALSGSKGSNINIS 791
                         ..::.....|::....:..|.|.. .||   |.|:..:|..||:|||.:|..
  Rat   853 WQDAHLGKDQRDFNMIDMKFKEEVNHYSNEINKACMPFGLHRQFPENNLQMMVQSGAKGSTVNTM 917

  Fly   792 QMIACVGQQAISGKRVPNGFENRALPHFERHSAIPAARGFVQNSFYSGLTPTEFFFHTMAGREGL 856
            |:...:||..:.|:|.|.....::||.||.:...|.|.|||...|.:|:.|.|||||.|||||||
  Rat   918 QISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIRPPEFFFHCMAGREGL 982

  Fly   857 VDTAVKTAETGYLQRRLVKCLEDLVVHYDGTVRNAVNEMVDTIYGGDGLD--------------- 906
            |||||||:.:|||||.::|.||.||:.||.|||::...:|..:||.||||
  Rat   983 VDTAVKTSRSGYLQRCIIKHLEGLVIQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQFPFL 1047

  Fly   907 ----PVSME--------TRNKPVDLVHQYDNLRAQHPQGKDRPLN-------AEEMSEALETLL- 951
                .|.|:        :|..|..::..:..::..|.:.....|.       ::::..|::.|.
  Rat  1048 ASNYEVIMKSKHLHEVLSRADPQKVLRHFRAIKKWHHRHSSALLRKGAFLSFSQKIQAAVKALNL 1112

  Fly   952 -------RTPEFAEARDDFKLDVRNHINTVSKRIGQLQKR------------------------Y 985
                   |:||..:     .|.:.:.::..|:|  :.|||                        :
  Rat  1113 EGKTQNGRSPETQQ-----MLQMWHELDEQSRR--KYQKRAAPCPDPSLSVWRPDIHFASVSETF 1170

  Fly   986 EKCID-----------LCHQIECLTTEQLLQFVRRINDRYNRAVTEPGTAVGAIAAQSIGEPGTQ 1039
            ||.||           ..|....|:.::|...::.   ::.|::.:||.|||.:||||||||.||
  Rat  1171 EKKIDDYSQEWAAQAEKSHNRSELSLDRLRTLLQL---KWQRSLCDPGEAVGLLAAQSIGEPSTQ 1232

  Fly  1040 MTLKTFHFAGVASMNITQGVPRIVEIIN-ATKTISTPIITAELENC-HSMEFARQVKARIEKTTL 1102
            |||.||||||...||:|.|:||:.||:. |:..|.||:::..:.|. .::...:.:|.::.:..|
  Rat  1233 MTLNTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVFNTKKALRRVKSLKKQLTRVCL 1297

  Fly  1103 AELSSYVEV---VCG-----------------PYSCYLAIGVDMARIKLLG----LHIDLDTIVF 1143
            .|:...|::   .|.                 |::.|       .:.|.|.    ||. ::|..|
  Rat  1298 GEVLQKVDIQESFCMGEKQNKFRVYELRFQFLPHAYY-------QQEKCLRPEDILHF-METRFF 1354

  Fly  1144 SILKSRMRVKPTQVEVVAS------------------------------QSRIV----------- 1167
            .:|...::.|.::.....|                              :..||
  Rat  1355 KLLMEAIKKKNSKASAFRSVNTRRATQKDLDDTEDSGRNRREEERDEEEEGNIVDAEAEEGDADA 1419

  Fly  1168 ----------------------------------------------------------------- 1167
                                                                             
  Rat  1420 SDTKRKEKQEEEVDYESEEEGEEEEEEDVQEEENIKGEGAHQTHEPDEEEGSGLEEESSQNPPRR 1484

  Fly  1168 -----------VRVEATRTS--------------------------TINAELARLALSL-QNVVV 1194
                       .|::|.|.|                          .||.:::.|.:|| .|.:|
  Rat  1485 HSRPQGAEAMERRIQAVRESHSFIEDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHNAIV 1549

  Fly  1195 AGLPNINRAVI-AVDDARQPPTYKLCIEGYGLRDVIATYGVVG-KRTRSNNICEIYQTLGIEAAR 1257
            .....|.|.:: ...:::....:.|..||..|.::.....|:. :|..||:|..:..|.|||||.
  Rat  1550 YTTKGITRCLLNETINSKNEKEFVLNTEGINLPELFKYSEVLDLRRLYSNDIHAVANTYGIEAAL 1614

  Fly  1258 TIIMSEITEVMEGHGMSVDWRHIMLLASQMTARGEVLGITRHGLAKMRESVFNLASFEKTADHLF 1322
            .:|..||.:|...:|::||.||:.|:|..|...|....:.|.|: :...|.....:||.:...|.
  Rat  1615 RVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGI-QSSSSPLQQMTFETSFQFLK 1678

  Fly  1323 DAAYYGQTDAINGVSERIILGMPACIGTGIFKLLQ 1357
            .|...|..|.:...|..:::|.....|||:|:|.|
  Rat  1679 QATMMGSHDELKSPSACLVVGKVVKGGTGLFELKQ 1713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RpIIIC160	NP_001096987.2	PRK08566	13..919	CDD:236292	312/1128 (28%)
		RNAP_III_RPC1_N	24..889	CDD:259847	297/1060 (28%)
		RNA_pol_Rpb1_5	839..1304	CDD:282807	166/713 (23%)
		RNAP_III_Rpc1_C	1013..1353	CDD:132723	111/511 (22%)
Polr1a	NP_113960.2	RNAP_I_RPA1_N	16..1011	CDD:259844	296/1061 (28%)
		RNA_pol_Rpb1_5	965..1666	CDD:398596	167/719 (23%)
		Bridging helix. /evidence=ECO:0000250	968..980		9/11 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1368..1493		3/124 (2%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820