DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIIIC160 and NRPB1

DIOPT Version :9

Sequence 1:	NP_001096987.2	Gene:	RpIIIC160 / 32524	FlyBaseID:	FBgn0030687	Length:	1383	Species:	Drosophila melanogaster
Sequence 2:	NP_001329346.1	Gene:	NRPB1 / 829734	AraportID:	AT4G35800	Length:	1839	Species:	Arabidopsis thaliana

Alignment Length:	1532	Identity:	511/1532 - (33%)
Similarity:	756/1532 - (49%)	Gaps:	245/1532 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KISHVQFGISGADEIQQEALVRIISKNLYQAQRQPVPYGVLDRRMGISTKDAMCETCGQGLNECI 78
            |:..|||||...|||:|.:::.:......: :.:|...|:.|.|:|...:...||||...:.||.
plant    14 KVRVVQFGILSPDEIRQMSVIHVEHSETTE-KGKPKVGGLSDTRLGTIDRKVKCETCMANMAECP 77

  Fly    79 GHFGYLDLALPVFHIGHFRSTINILQMICKVCAHVMLKPEDRQLYE-KKLHNPNFSYLGKKALHV 142
            ||||||:||.|::|:|..::.::|::.:|..|:.::...|:.:..: .|:.||      |..|.
plant    78 GHFGYLELAKPMYHVGFMKTVLSIMRCVCFNCSKILADEEEHKFKQAMKIKNP------KNRLK- 135

  Fly   143 QMLAKAKKVTKCPHCGSPNGG--------------VKKGPGLLKILHDPYKGRKMDSLFTSNMNE 193
            ::|...|..|||      :||              |||..|..        |.:...|....| :
plant   136 KILDACKNKTKC------DGGDDIDDVQSHSTDEPVKKSRGGC--------GAQQPKLTIEGM-K 185

  Fly   194 MLRSTQTNRDLN-------------STLGNYSTAEELTPLMVLDLFEQIPQRDVALLGMCSHDAH 245
            |:...:..|..|             .|||    |:.     ||.:.::|...|..|||.....|.
plant   186 MIAEYKIQRKKNDEPDQLPEPAERKQTLG----ADR-----VLSVLKRISDADCQLLGFNPKFAR 241

  Fly   246 PKHLIVTRVFVPPACIRPSVLSEVKAGTTEDDLTMKQSEILLINDVIQRHMATGGKIELIHEDWD 310
            |..:|:..:.:||..:||||:.:. ...:|||||.:.:.|:..|:.::|....|....:|.|...
plant   242 PDWMILEVLPIPPPPVRPSVMMDA-TSRSEDDLTHQLAMIIRHNENLKRQEKNGAPAHIISEFTQ 305

  Fly   311 FLQLHVALYFHSEISGIPINMAPKKTTR---GIVQRLKGKQGRFRCNLSGKRVDFSGRTVISPDP 372
            .||.|:|.||.:|:.|.|  .|.:|:.|   .|..|||.|:||.|.||.|||||||.||||:|||
plant   306 LLQFHIATYFDNELPGQP--RATQKSGRPIKSICSRLKAKEGRIRGNLMGKRVDFSARTVITPDP 368

  Fly   373 NLMINQVGVPVRVAKILTYPERVNPANIRHMRELVRNGPSMHP-----GANY-VQQRGSSFK-KY 430
            .:.|:::|||..:|..|||||.|.|.||..::|||..||  ||     ||.| ::..|.... :|
plant   369 TINIDELGVPWSIALNLTYPETVTPYNIERLKELVDYGP--HPPPGKTGAKYIIRDDGQRLDLRY 431

  Fly   431 LAYGNREKVAQELKCGDVVERHLRDGDIVLFNRQPSLHKMSIMCHRAKVQPQRTFRFNECACTPY 495
            |    ::...|.|:.|..|||||:|||.|||||||||||||||.||.::.|..|||.|....:||
plant   432 L----KKSSDQHLELGYKVERHLQDGDFVLFNRQPSLHKMSIMGHRIRIMPYSTFRLNLSVTSPY 492

  Fly   496 NADFDGDEMNLHLPQTEEARAEALILMGNQSNLVTPKNGEILIAATQDFITGGYLLTQKEVFLTK 560
            ||||||||||:|:||:.|.|||.|.||.....:|:|:....::...||.:.|...:|:::.|:.|
plant   493 NADFDGDEMNMHVPQSFETRAEVLELMMVPKCIVSPQANRPVMGIVQDTLLGCRKITKRDTFIEK 557

  Fly   561 EEAMQLAACFLANEDSTMHIKLPPPALLKPRRLWTGKQMFSLLMRPNDDSQVRLNMVNKGRNYTR 625
            :..|.....:   ||  ...|:|.||:||||.||||||:|:|::    ..|:.|...:.....|.
plant   558 DVFMNTLMWW---ED--FDGKVPAPAILKPRPLWTGKQVFNLII----PKQINLLRYSAWHADTE 613

  Fly   626 NKDLCSNDSWIHIRNSELMCGVMDKATMGSGTKQCIFYLLLRDFGESHATKAMWRLARIASYFLQ 690
            ...:...|:.:.|...||:.|.:.|.|:|:.....: :::..:.|...|.|.:.....:.:|:|.
plant   614 TGFITPGDTQVRIERGELLAGTLCKKTLGTSNGSLV-HVIWEEVGPDAARKFLGHTQWLVNYWLL 677

  Fly   691 NRGFSFGISDVTPSKKLLQHKELLLNNGYAKCNEYIELLKAGTLQCQPGCTPEETLESVMLRELS 755
            ..||:.||.|.......::.....::|......:.|...:...|..:||.|..:|.|:.:.:.|:
plant   678 QNGFTIGIGDTIADSSTMEKINETISNAKTAVKDLIRQFQGKELDPEPGRTMRDTFENRVNQVLN 742

  Fly   756 AIREQAAKTCFAELHPTNSALIMALSGSKGSNINISQMIACVGQQAISGKRVPNGFENRALPHFE 820
            ..|:.|..:....|..||:...|..:|||||.||||||.||||||.:.|||:|.||:.|.||||.
plant   743 KARDDAGSSAQKSLAETNNLKAMVTAGSKGSFINISQMTACVGQQNVEGKRIPFGFDGRTLPHFT 807

  Fly   821 RHSAIPAARGFVQNSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYLQRRLVKCLEDLVVHYD 885
            :....|.:||||:||:..||||.|||||.|.|||||:||||||:||||:||||||.:||::|.||
plant   808 KDDYGPESRGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTSETGYIQRRLVKAMEDIMVKYD 872

  Fly   886 GTVRNAVNEMVDTIYGGDGLDPV--------SMETRNKPVDLVHQYD---------NLRAQHPQG 933
            |||||::.:::..:||.||:|.|        |::.:....|...:|:         .|..:|.:.
plant   873 GTVRNSLGDVIQFLYGEDGMDAVWIESQKLDSLKMKKSEFDRTFKYEIDDENWNPTYLSDEHLED 937

  Fly   934 KDRPLNAEEMSEALETLLRTPEFA------------------------EARDDFKLDVRN----H 970
            ........::.:|..:.|.|..|.                        .|:..||:|:|.    |
plant   938 LKGIRELRDVFDAEYSKLETDRFQLGTEIATNGDSTWPLPVNIKRHIWNAQKTFKIDLRKISDMH 1002

  Fly   971 INTVSKRIGQLQKRY-------------EKCIDLCHQI---ECLTTEQLLQ-----------FVR 1008
            ...:...:.:||:|.             :|...|...|   ..|.::::|:           .:.
plant  1003 PVEIVDAVDKLQERLLVVPGDDALSVEAQKNATLFFNILLRSTLASKRVLEEYKLSREAFEWVIG 1067

  Fly  1009 RINDRYNRAVTEPGTAVGAIAAQSIGEPGTQMTLKTFHFAGVASMNITQGVPRIVEIINATKTIS 1073
            .|..|:.:::..||..:|.:||||||||.|||||.|||:|||::.|:|.||||:.||||..|.|.
plant  1068 EIESRFLQSLVAPGEMIGCVAAQSIGEPATQMTLNTFHYAGVSAKNVTLGVPRLREIINVAKRIK 1132

  Fly  1074 TPIITAEL--ENCHSMEFARQVKARIEKTTLAELSSYVEVVCGPYSCYLAIGVD----------- 1125
            ||.::..|  |...|.|.|:.|:..:|.|||..::...||...|......|..|
plant  1133 TPSLSVYLTPEASKSKEGAKTVQCALEYTTLRSVTQATEVWYDPDPMSTIIEEDFEFVRSYYEMP 1197

  Fly  1126 ------------MARIKL------------------LGLHIDLD-TIVFS-------ILKSRMR- 1151
                        :.||:|                  :.|..|.| |.:|:       ||:.|:.
plant  1198 DEDVSPDKISPWLLRIELNREMMVDKKLSMADIAEKINLEFDDDLTCIFNDDNAQKLILRIRIMN 1262

  Fly  1152 ---VKPTQVEVVASQSRIVVRVEATRTSTINAELARLALSLQNVVVAGLPNINRAVI------AV 1207
               .|....:..|.....:.::|:.              .|..:.:.|:|:||:..|      ..
plant  1263 DEGPKGELQDESAEDDVFLKKIESN--------------MLTEMALRGIPDINKVFIKQVRKSRF 1313

  Fly  1208 DDA---RQPPTYKLCIEGYGLRDVIATYGVVGKRTRSNNICEIYQTLGIEAARTIIMSEITEVME 1269
            |:.   :....:.|..||..|..|:....|..|||.||::.||.:.|||||.|..::.|:..|:.
plant  1314 DEEGGFKTSEEWMLDTEGVNLLAVMCHEDVDPKRTTSNHLIEIIEVLGIEAVRRALLDELRVVIS 1378

  Fly  1270 GHGMSVDWRHIMLLASQMTARGEVLGITRHGLAKMRESVFNLASFEKTADHLFDAAYYGQTDAIN 1334
            ..|..|::||:.:|...||.||.::.|||||:.:.........|||:|.|.|.|||.|.:||.:.
plant  1379 FDGSYVNYRHLAILCDTMTYRGHLMAITRHGINRNDTGPLMRCSFEETVDILLDAAAYAETDCLR 1443

  Fly  1335 GVSERIILGMPACIGTGIFKLLQQHE------DKQVP 1365
            ||:|.|:||..|.||||..:|....|      :.|:|
plant  1444 GVTENIMLGQLAPIGTGDCELYLNDEMLKNAIELQLP 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIIIC160	NP_001096987.2	PRK08566	13..919	CDD:236292	353/950 (37%)
		RNAP_III_RPC1_N	24..889	CDD:259847	337/902 (37%)
		RNA_pol_Rpb1_5	839..1304	CDD:282807	179/600 (30%)
		RNAP_III_Rpc1_C	1013..1353	CDD:132723	131/403 (33%)
NRPB1	NP_001329346.1	RNAP_II_RPB1_N	18..872	CDD:259848	338/904 (37%)
		RNA_pol_Rpb1_6	892..1076	CDD:398590	27/183 (15%)
		RNAP_II_Rpb1_C	1055..1467	CDD:132720	133/425 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	1	1.000	-	-		FOG0000819
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100210
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720