DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpIIIC160 and polr3a

DIOPT Version :9

Sequence 1:	NP_001096987.2	Gene:	RpIIIC160 / 32524	FlyBaseID:	FBgn0030687	Length:	1383	Species:	Drosophila melanogaster
Sequence 2:	XP_021335832.1	Gene:	polr3a / 572258	ZFINID:	ZDB-GENE-050208-103	Length:	1402	Species:	Danio rerio

Alignment Length:	1400	Identity:	785/1400 - (56%)
Similarity:	1016/1400 - (72%)	Gaps:	33/1400 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKEQFRASALNKKISHVQFGISGADEIQQEALVRIISKNLY--QAQRQPVPYGVLDRRMGISTK 63
            |.|||||.:.:.:||||:.||:..:::::|:|.::::|||||  ....:|:.|||||.|||.|.|
Zfish     1 MVKEQFRETDVARKISHICFGMKSSEQMRQQAHIQVVSKNLYSQDTSHKPLQYGVLDHRMGTSEK 65

  Fly    64 DAMCETCGQGLNECIGHFGYLDLALPVFHIGHFRSTINILQMICKVCAHVMLKPEDRQLYEKKLH 128
            |..|||||:.|.:|:||:|||||.||.||||:|::.:.|||||||.|:|::|..|::..:...|.
Zfish    66 DRPCETCGKNLADCLGHYGYLDLELPCFHIGYFKAIVGILQMICKTCSHILLTKEEKLQFLDYLR 130

  Fly   129 NPNFSYLGKKALHVQMLAKAKKVTKCPHCGSPNGGVKKGPGLLKILHDPYKGRK--MDSLFTSNM 191
            .|..:||.|:.|..::..|.:|.|.|.:|.:.||.||| .|||||:|:.||..|  :|...:..:
Zfish   131 RPGLAYLQKRGLKKKISDKCRKKTVCLNCNAFNGSVKK-CGLLKIIHEKYKSTKKVVDPAVSDFL 194

  Fly   192 NEMLRSTQTNRDLNSTLGNYSTAEELTPLMVLDLFEQIPQRDVALLGMCSHDAHPKHLIVTRVFV 256
            .....:.:.|:::.|.|..  ..|.|.||:||:||.:||.:||.||.|......|..||:||:.|
Zfish   195 QSFDVAIEHNKEVESLLTR--AQENLNPLVVLNLFRRIPDKDVPLLLMNPESGKPADLILTRLLV 257

  Fly   257 PPACIRPSVLSEVKAGTTEDDLTMKQSEILLINDVIQRHMATGGKIELIHEDWDFLQLHVALYFH 321
            ||.||||||:|::|:||.|||||||.:||:.:||||::|..||.|.::|.||||||||..|||.:
Zfish   258 PPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRMTGAKTQMIMEDWDFLQLQCALYIN 322

  Fly   322 SEISGIPINMAPKKTTRGIVQRLKGKQGRFRCNLSGKRVDFSGRTVISPDPNLMINQVGVPVRVA 386
            ||:||||:||||||.|||.||||||||||||.|||||||||||||||||||||.|::|.|||.||
Zfish   323 SELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVA 387

  Fly   387 KILTYPERVNPANIRHMRELVRNGPSMHPGANYVQQRGSSFKKYLAYGNREKVAQELKCGDVVER 451
            |||||||:||.|||..||:||||||.:|||||::|||....|::|.||||||:|||||.||||||
Zfish   388 KILTYPEKVNKANIELMRKLVRNGPEVHPGANFIQQRHMQMKRFLKYGNREKMAQELKFGDVVER 452

  Fly   452 HLRDGDIVLFNRQPSLHKMSIMCHRAKVQPQRTFRFNECACTPYNADFDGDEMNLHLPQTEEARA 516
            |:.|||||||||||||||:|||.|.|:|:|.||||||||.|||||||||||||||||||||||:|
Zfish   453 HMIDGDIVLFNRQPSLHKLSIMAHIARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKA 517

  Fly   517 EALILMGNQSNLVTPKNGEILIAATQDFITGGYLLTQKEVFLTKEEAMQLAACFLANEDSTMHIK 581
            |||:|||.::|||||:|||.||||.|||:||.||||.|:.|..:.:|.|:.|..|..:|..:.|.
Zfish   518 EALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRTKACQIVASILVGKDEKIKIS 582

  Fly   582 LPPPALLKPRRLWTGKQMFSLLMRPNDDSQVRLNMVNKGRNYT-RNKDLCSNDSWIHIRNSELMC 645
            ||.||:|||.|||||||:|||:::|:....|..|:..||:.|. :.:|||:|||::.|.||||||
Zfish   583 LPHPAILKPIRLWTGKQIFSLILKPSKSCPVMANLRTKGKQYCGKGEDLCANDSFVVIHNSELMC 647

  Fly   646 GVMDKATMGSGTKQCIFYLLLRDFGESHATKAMWRLARIASYFLQNRGFSFGISDVTPSKKLLQH 710
            |.|||.|:|||:|..|||:||||:|:..|..||.||||:|..:|.|||||.||.||||.:.||:.
Zfish   648 GSMDKGTLGSGSKNNIFYILLRDWGQQEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKA 712

  Fly   711 KELLLNNGYAKCNEYIELLKAGTLQCQPGCTPEETLESVMLRELSAIREQAAKTCFAELHPTNSA 775
            |:.||:.||.||:|||:.||.|.||.|||||.|||||:::|:|||.||:.|...|..||..:||.
Zfish   713 KQELLDAGYEKCDEYIDALKTGRLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSP 777

  Fly   776 LIMALSGSKGSNINISQMIACVGQQAISGKRVPNGFENRALPHFERHSAIPAARGFVQNSFYSGL 840
            |||||.|||||.|||||||||||||||||.|||:|||||:||||::||.:|||:|||.:||||||
Zfish   778 LIMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFQKHSKLPAAKGFVADSFYSGL 842

  Fly   841 TPTEFFFHTMAGREGLVDTAVKTAETGYLQRRLVKCLEDLVVHYDGTVRNAVNEMVDTIYGGDGL 905
            ||||||||||||||||||||||||||||:||||||.||||...||.|||::..:::..|||||||
Zfish   843 TPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGL 907

  Fly   906 DPVSMETRNKPVDLVHQYDNLRAQHPQGKDRPLNAEEMSEALETLLRTPEFAEARDDF------- 963
            ||.:||.:::|::.....||:||.:....:..|:..|:....:::::..:|...:|.|
Zfish   908 DPAAMEGKDEPLEFKRVLDNIRAVYSCTGEPALSRNELLLTSDSIMKRKDFLCCKDTFLETLTDT 972

  Fly   964 -----KLDVRNHINTVSKRIGQLQKRY---------EKCIDLCHQIECLTTEQLLQFVRRINDRY 1014
                 ..::|..|.|||:::.:.:.:|         .|.:   :|::.:|..||.:|:....|:|
Zfish   973 GSDKYMQEIRKFIKTVSEKVKKTRDKYGINDNGTTEPKVL---YQLDRITPTQLEKFLETCRDKY 1034

  Fly  1015 NRAVTEPGTAVGAIAAQSIGEPGTQMTLKTFHFAGVASMNITQGVPRIVEIINATKTISTPIITA 1079
            .||..|||:||||:.|||||||||||||||||||||||||||.|||||.|||||:|.||||||:|
Zfish  1035 MRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKNISTPIISA 1099

  Fly  1080 ELENCHSMEFARQVKARIEKTTLAELSSYVEVVCGPYSCYLAIGVDMARIKLLGLHIDLDTIVFS 1144
            .|:.....:|||.||.|||||.|.|:|.|:|.|..|...::.:.:.:.||:||.|.::.:|:.:|
Zfish  1100 NLDTNDDPDFARLVKGRIEKTLLGEISEYIEEVFLPDDTFILVKLSLDRIRLLRLEVNAETVRYS 1164

  Fly  1145 ILKSRMRVKPTQVEVVASQSRIVVRVEATRTSTINAELARLALSLQNVVVAGLPNINRAVIAVDD 1209
            |..|::||||..|: |..::.:.|.......|::...|..|...|..|||.|:|.::||||.:|:
Zfish  1165 ICTSKLRVKPGDVQ-VHGEAVVCVSPRENSKSSMYYVLQSLKQDLPKVVVQGIPEVSRAVIHIDE 1228

  Fly  1210 ARQPPTYKLCIEGYGLRDVIATYGVVGKRTRSNNICEIYQTLGIEAARTIIMSEITEVMEGHGMS 1274
            ......:||.:||..:|.|:||:||.|.:|.|||..|:.:||||||||:.|::||...|..||||
Zfish  1229 QSGKQKFKLLVEGDNMRSVMATHGVNGSKTTSNNTYEVEKTLGIEAARSTIINEIQYTMVNHGMS 1293

  Fly  1275 VDWRHIMLLASQMTARGEVLGITRHGLAKMRESVFNLASFEKTADHLFDAAYYGQTDAINGVSER 1339
            :|.||:||||..|:.:||:|||||.|||||:|||..||||||||||||||||:||.|::.||||.
Zfish  1294 IDRRHVMLLADLMSYKGEILGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSEC 1358

  Fly  1340 IILGMPACIGTGIFKLLQQHEDKQVPPIEPTICSS 1374
            ||:|:|..||||:||||.:...:..||..|.:..|
Zfish  1359 IIMGIPMNIGTGLFKLLHRSNREADPPRRPLLFDS 1393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpIIIC160	NP_001096987.2	PRK08566	13..919	CDD:236292	560/910 (62%)
		RNAP_III_RPC1_N	24..889	CDD:259847	540/869 (62%)
		RNA_pol_Rpb1_5	839..1304	CDD:282807	232/485 (48%)
		RNAP_III_Rpc1_C	1013..1353	CDD:132723	189/339 (56%)
polr3a	XP_021335832.1	RNAP_III_RPC1_N	24..891	CDD:259847	540/869 (62%)
polr3a	XP_021335832.1	RNAP_III_Rpc1_C	1033..1372	CDD:132723	189/339 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584005
Domainoid	1	1.000	439	1.000	Domainoid score	I533
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5124
Inparanoid	1	1.050	1527	1.000	Inparanoid score	I96
OMA	1	1.010	-	-		QHG53760
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	1	1.000	-	-		FOG0000819
OrthoInspector	1	1.000	-	-		oto39854
orthoMCL	1	0.900	-	-		OOG6_100210
Panther	1	1.100	-	-	LDO	PTHR19376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3228
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910